Core C: Data Management and Statistical Core

核心C：数据管理与统计核心

• 批准号: 9172552
• 负责人: JONATHAN D MAHNKEN
• 金额: $ 19.94万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9172552
• 关键词: Adherence; Aging; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Bioinformatics; Biometry; Clinical; Clinical Data; Collaborations; Communities; Computer software; Data; Data Analyses; Data Collection; Data Files; Data Quality; Databases; Development; Dictionary; Ensure; Faculty; Freezing; Funding; Genomics; Human Resources; Informatics; Internal Medicine; Investigation; Kansas; Leadership; Literature; Management Information Systems; Manuscripts; Measures; Medical Informatics; Metabolism; Metadata; Methodology; Mitochondria; Monitor; Names; Neurodegenerative Disorders; Online Systems; Phase; Phenotype; Pilot Projects; Play; Preparation; Process; Protocols documentation; Publications; Publishing; Records; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Sampling; Services; Staging; Statistical Data Interpretation; Support System; System; Training; Translations; Universities; Update; abstracting; cohort; data management; design; distributed data; electronic data; experience; neuroimaging; novel; operation; programs; repository; research study; sound; statistics; success; user-friendly

ABSTRACT: DATA MANAGEMENT AND STATISTICS (DMS) CORE The Data Management and Statistics (DMS) Core (Core C) supports The University of Kansas Alzheimer’s Disease Center (KU ADC). Our personnel are faculty and staff from the Department of Biostatistics and from the Division of Medical Informatics within the Department of Internal Medicine. DMS Core faculty and staff have the training and experience to support the research needs of investigators that utilize KU ADC resources. The central focus of this core is managing and maintaining the entire spectrum of study-related information for the Clinical Cohort that is collected across the cores and research projects. To support this objective, the DMS core created and maintains a REDCap web-based data capture platform. DMS Core staff prepares data extracts for investigators and NACC and provide statistical, informatics, and bioinformatics expertise for research using the KU ADC. AD research is supported by the DMS Core under the following specific aims. Aim 1: Maintain data and information management systems and adapt to the KU ADC’s evolving needs. The DMS Core continually develops and supports the systems needed by the various core and projects. Data capture forms are built for research projects. Data from the Clinical Cohort are efficiently uploaded to the coordinating center (NACC). Aim 2: Enhance the quality of AD and aging research by providing investigators with statistical and bioinformatics expertise. The DMS Core aids investigators in designing their research studies and provides statistical oversight and analytic support. This support includes active participation in preparing research presentations and publications to ensure proper interpretations of findings. We also develop novel statistical methodology to enhance interpretations of experimental and observational data collected for AD research. The DMS Core remains highly integrated across the cores. The DMS Core provides data management, data extracts, and statistical support and plays a key role as a liaison for core-to-core and core-to-research project interactions. The Core also supports the development, informatics, statistical, and bioinformatics needs of KU ADC pilot projects.

摘要：数据管理和统计（DMS）核心 数据管理和统计（DMS）核心（核心C）支持堪萨斯大学阿尔茨海默氏症 疾病中心（KU ADC）。我们的工作人员是来自生物统计学系和来自 内科医学信息学部。DMS核心教职员工 有培训和经验，以支持利用KU ADC资源的研究人员的研究需求。 该核心的核心重点是管理和维护整个研究相关信息， 在核心和研究项目中收集的临床队列。为了支持这一目标，DMS 核心创建并维护了一个基于网络的数据采集平台。管理事务司核心工作人员准备数据 为研究者和NACC提供摘录，并为以下方面提供统计、信息学和生物信息学专业知识： 使用KU ADC进行研究。反倾销研究由DMS核心支持，具体目标如下。 目标1：维护数据和信息管理系统，并适应KU ADC不断变化的需求。 DMS核心不断开发和支持各种核心和项目所需的系统。数据 捕获表单是为研究项目构建的。来自临床队列的数据被有效地上传到 协调中心（NACC）。 目标2：通过为研究者提供统计和 生物信息学专业知识。DMS核心帮助研究人员设计他们的研究，并提供 统计监督和分析支助。这种支持包括积极参与研究准备工作 报告和出版物，以确保对调查结果的正确解释。我们还开发新颖的统计数据 方法，以加强对AD研究收集的实验和观察数据的解释。 DMS核心在各个核心之间保持高度集成。DMS核心提供数据管理， 数据提取和统计支持，并在核心对核心和核心对研究的联络中发挥关键作用 项目互动。该核心还支持发展、信息学、统计和生物信息学需求 KU ADC试点项目。