体内 K27M 组蛋白突变的功能解析-猫眼课题宝

体内 K27M 组蛋白突变的功能解析

批准号：

8826199

负责人：

Oren Josh Becher

金额：

$19.49万

依托单位：

DUKE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-09-01 至 2019-08-31

来源：

https://reporter.nih.gov/project-details/8826199

关键词：

Accounting Astrocytes Biology Brain Neoplasms Brain Stem Brain Stem Glioma Brain Stem Neoplasms Cause of Death Cell Proliferation Cells Child Childhood Brain Neoplasm Clinical Trials Complex Development Diffuse Disease Dissection Dorsal Foundations Gene Targeting Genes Genetic Genetically Engineered Mouse Glial Fibrillary Acidic Protein Glioma Gliomagenesis Goals Health Histone H3.3 Histones Human In Vitro Independent Scientist Award Laboratories Location Malignant Neoplasms Malignant neoplasm of brain Modeling Molecular Profiling Mus Mutation Neonatal Pathogenesis Pharmaceutical Preparations Platelet-Derived Growth Factor Polycomb Pontine structure Proto-Oncogene Proteins c-sis Relative (related person)Reporting Research Scientist Therapeutic Agents comparative design differential expression effective therapy gain of function mutation in vivo mouse model mutant nerve stem cell nestin protein novel overexpression progenitor relating to nervous system transcriptome sequencing tumor tumorigenesis

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DESCRIPTION (provided by applicant): Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain tumor that arises in children. My laboratory is one of very few laboratories around the world that is studying DIPG biology using genetically engineered mouse modeling. This Independent Scientist Award will give me the opportunity to focus on research to dissect the mechanisms by which K27M histone mutations contribute to DIPG pathogenesis. Ultimately, this information will lay the groundwork for the identification of effective therapeutic agents to treat this incurable cancer.

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