Functional Dissection of the K27M Histone Mutation in Vivo

描述(申请人提供)：弥漫性固有桥脑胶质瘤(DIPG)是一种不可治愈的脑肿瘤，发生在儿童。我的实验室是世界上为数不多的使用转基因小鼠模型研究DIPG生物学的实验室之一。这个独立科学家奖将让我有机会专注于研究，剖析K27M组蛋白突变在DIPG发病机制中的作用。最终，这些信息将为确定治疗这种无法治愈的癌症的有效治疗剂奠定基础。

DESCRIPTION (provided by applicant): Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain tumor that arises in children. My laboratory is one of very few laboratories around the world that is studying DIPG biology using genetically engineered mouse modeling. This Independent Scientist Award will give me the opportunity to focus on research to dissect the mechanisms by which K27M histone mutations contribute to DIPG pathogenesis. Ultimately, this information will lay the groundwork for the identification of effective therapeutic agents to treat this incurable cancer.