Genomics

基因组学核心的目标是为#年进行的基因组分析提供全面支持 每一个Gl孢子项目的案例。基因组核心公司将利用在以下方面的重大投资 CWRU在学院的支持下创建的公共和共享基础设施 医学、病例综合癌症中心和霍华德·休斯医学研究所。CWRU和 癌症中心的核心资源是该孢子的一部分，一直是NIH支持的主题，并 因此，该孢子将利用现有的支助来提供每个项目 获得最先进的基因组规模分析专业知识。基因组学核心建立在现有核心之上 在绩效和成功方面有显著记录的设施，以及教职员工互动 它们支持本应用程序的每个项目中呈现的组件的初始工作。这个 基因组学核心将成为提供高通量基因分型和下一代技术的中心资源 两个项目的DNA测序能力。此外，核心将制定和实施其他 必要时支持所有项目的方法，包括试点项目。设备和人员 在基因组学核心支持研究活动中提供，这些活动需要仪器和专业知识， 在个别项目PI的实验室中不可用或不实用，并为其集中 为了实现流程标准化和规模经济，需要进行分析。具体地说， 基因组学核心将执行特定区域的DNA捕获和高通量DNA测序 支持各个孢子项目的基因分型。基因组学核心将与 用于获取用于分析的材料的质量评估的样品和组织芯 用于数据质量评估和分析的生物统计核心。

The goal of the Genomics Core is to provide comprehensive support for genomic analyses carried out in each of the Case Gl SPORE Projects. The Genomics Core will capitalize on the significant investment in common and shared infrastructure that has been created at CWRU, with support from the School of Medicine, the Case Comprehensive Cancer Center, and the Howard Hughes Medical Institute. CWRU and Cancer Center core resources that are part of this SPORE have been the subject of NIH support and are partially funded as such; thus, this SPORE will be leveraging the existing support to provide each project access to state-of-the-art genome-scale analysis expertise. The Genomics Core builds on exisfing core facilities that have a significant track record of performance and success, as well as the faculty interactions which have supported the initial work for components presented within each Project of this application. The Genomics Core will be a central resource for providing high-throughput genotyping and 'next-generation' DNA sequencing capability for two Projects. In addition, the Core will develop and implement additional methods as necessary to support all Projects, including Pilot Projects. The equipment and personnel available in the Genomics Core support research activities that require instrumentation and expertise that are not available or practical in the laboratories of the individual Project Pis, and for which centralized analyses are required in order to achieve process standardization and economies-of-scale. Specifically, the Genomics Core will perform region-specific DNA capture and high-throughput DNA sequencing and genotyping in support of the individual SPORE Projects. The Genomics Core will work closely with the Specimen and Tissue Core for access to quality assessment of materials for analysis and with the Biostatistics Core for data quality assessment and analysis.