Translational Studies of Brain Circuitry Disrupted by Alcoholism

酒精中毒扰乱大脑回路的转化研究

• 批准号: 9120720
• 负责人: EDITH VIONI SULLIVAN
• 金额: $ 21.67万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-10 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9120720
• 关键词: Adolescent; Affect; Age; Aging; Alcohol consumption; Alcoholism; Alcohols; Amygdaloid structure; Animal Model; Animals; Area; Award; Behavioral; Behavioral Sciences; Biological Markers; Brain; Brain Injuries; Brain region; Cerebrovascular Circulation; Chronic; Clinical; Cognitive; Collaborations; Communities; Complement; Development; Diffusion Magnetic Resonance Imaging; Dose; Drug usage; Educational process of instructing; Environment; Equilibrium; Exhibits; Exposure to; Faculty; Fiber; Financial compensation; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Heavy Drinking; Human; Image; Impairment; International; Laboratories; Location; Magnetic Resonance Imaging; Malnutrition; Measures; Mental Health; Mentors; Methods; Modeling; Motor; NIH Program Announcements; Names; National Institute on Alcohol Abuse and Alcoholism; Neuropsychological Tests; Neurosciences; Neurosciences Research; Pattern; Performance; Physiologic pulse; Process; Productivity; Psychiatry; Psychology; Public Health; Radiology Specialty; Rattus; Recovery of Function; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Research Scientist Award; Resources; Rest; Role; Scanning; Scientist; Senior Scientist Award; Sensory; Severities; Site; Spin Labels; Structure; Students; Support System; System; Targeted Research; Testing; Thinking; Training; Translating; United States National Institutes of Health; Universities; Ventral Striatum; Visual; Visuospatial; addiction; alcohol exposure; alcohol use disorder; alcohol use initiation; arm; blood oxygen level dependent; brain circuitry; career development; conflict resolution; cytokine; design; gray matter; in vivo; innovation; liver injury; longitudinal design; medical schools; neural circuit; neuroadaptation; neuroimaging; neuropathology; neuropsychological; next generation; normal aging; physical conditioning; post-doctoral training; problem drinker; professor; programs; relating to nervous system; response; senescence; sex; skills; therapy design; translational study; white matter

DESCRIPTION (provided by applicant): This K05 continuing application is in response to an NIAAA Program Announcement (PA-12-148) for a Senior Scientist Award and represents a synthesis of NIH-funded projects on which I am principal or named investigator. As a professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, I am a scientist who conducts translational human and animal studies of the effects of alcoholism and aging on brain structure and function. The primary objective of this application is to extend my role as a scientist to that of a mentor who teaches and leads developing neuroscientists in all aspects of my neuroscience program. My program of research uses quantitative behavioral neuroscience approaches that are complemented with structural and functional magnetic resonance imaging (MRI and fMRI), diffusion tensor imaging (DTI), and pulse continuous arterial spin labeling (PCASL) with the aim of characterizing affected brain regions in alcoholism itself and in interaction with brain changes associated with development and senescence. My mentees will receive training in all aspects of my research with emphasis on behavioral experimental training for mentees with imaging backgrounds and training in imaging for mentees with psychology and behavioral backgrounds. I propose to have five mentees in each of the 5 years of the award, each for three to five years, all having completed postdoctoral training and now embarking on becoming independent investigators. Stanford University's neuroscience research community is dynamic, multifaceted, and interactive and attracts the brightest students, fellows, and faculty at all levels of career development. I have major collaborations in my own department as well as in Radiology, the Neuroscience Program, and SRI International. Fundamental to my research is access to advanced neuroimaging facilities and expertise for my own and my mentees' human and animal studies. The combined resources of my laboratory, across-site neuroimaging facilities, and the exceptional formal and informal neuroscience educational programs of the greater Stanford community provide a rich environment for my mentees. Common but often unrecognized untoward consequences of alcoholism are subtle but functionally significant impairments in cognitive, sensory, and motor functions. Identification of the brain systems supporting functions that remain relatively intact and those that are damaged in alcoholism with exacerbation from normal aging or subject to alcohol-related deviations from normal developmental trajectories is a crucial step in designing rehabilitation efforts for recruiting intact brain systems to compensate for damaged ones. Having the next generation of mentees engage in and then further their own research in these areas has notable potential relevance to public health concerns of addiction.

描述（由申请人提供）：此 K05 连续申请是对高级科学家奖的 NIAAA 计划公告 (PA-12-148) 的回应，代表了我担任主要或指定研究员的 NIH 资助项目的综合。作为斯坦福大学医学院精神病学和行为科学系的教授，我是一名科学家，致力于研究酗酒和衰老对大脑结构和功能的影响的人类和动物转化研究。此应用程序的主要目标是将我作为科学家的角色扩展到导师的角色，在我的神经科学项目的各个方面教授和领导发展中的神经科学家。我的研究项目使用定量行为神经科学方法，辅以结构和功能磁共振成像（MRI 和 fMRI）、扩散张量成像（DTI）和脉冲连续动脉自旋标记（PCASL），目的是表征酗酒本身以及与发育和衰老相关的大脑变化相互作用中受影响的大脑区域。我的学员将接受我研究的各个方面的培训，重点是对具有成像背景的学员进行行为实验培训，以及对具有心理学和行为背景的学员进行成像培训。我建议在该奖项的五年中每年有五名受训者，每人三到五年，他们都完成了博士后培训，现在开始成为独立研究者。斯坦福大学的神经科学研究社区充满活力、多元化、互动性强，吸引了职业发展各个层面的最聪明的学生、研究员和教师。我在自己的部门以及放射学、神经科学项目和 SRI International 都有重要的合作。我的研究的基础是为我自己和我的学员的人类和动物研究提供先进的神经影像设施和专业知识。我的实验室的综合资源、跨站点神经影像设施以及斯坦福大社区卓越的正式和非正式神经科学教育项目为我的学员提供了丰富的环境。酗酒常见但往往未被认识到的不良后果是认知、感觉和运动功能的微妙但功能上显着的损害。识别支持相对完整的功能的大脑系统和那些因正常衰老而加剧或因酒精相关而偏离正常发育轨迹的酗酒受损的大脑系统，是设计康复工作的关键一步，以招募完整的大脑系统来补偿受损的大脑系统。让下一代学员参与并进一步开展自己在这些领域的研究，与成瘾的公共卫生问题具有显着的潜在相关性。