COBRE for the Center for Molecular Medicine

COBRE 分子医学中心

• 批准号: 9317707
• 负责人: Louis B. Hersh
• 金额: $ 19.79万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9317707
• 关键词: Achievement; Advisory Committees; Aging; Anatomy; Area; Biochemistry; Cancer Center; Cardiovascular Diseases; Centers of Research Excellence; Clinical; Collaborations; Core Facility; Department chair; Development; Diabetes Mellitus; Ensure; Evaluation; Extramural Activities; Faculty; Fee-for-Service Plans; Funding; Goals; Grant; Growth; Growth and Development function; Image; Immunology; Institution; Instruction; Internal Medicine; Kentucky; Malignant Neoplasms; Medicine; Mentors; Microbiology; Molecular; Molecular Genetics; Molecular Medicine; National Institute of General Medical Sciences; Neurobiology; Neurodegenerative Disorders; Organic Synthesis; Paper; Pathology; Patients; Pediatrics; Peer Review; Pharmacology; Phase; Physiology; Pilot Projects; Positioning Attribute; Proteins; Proteomics; Psychiatry; Publishing; Readiness; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Scientist; Signal Transduction; Staging; Technology; Toxicology; Translational Research; Translations; United States National Institutes of Health; Universities; Work; arm; base; clinical practice; college; faculty mentor; genetic technology; human disease; mid-career faculty; programs; success; therapeutic target; voucher

This COBRE Phase III proposal aims to further develop the Center for Molecular Medicine at the University of Kentucky. This Center focuses on research aimed at understanding the molecular mechanisms associated with human disease with emphases on cancer, neurodegenerative diseases, diabetes, and cardiovascular diseases. We propose to transition to independence the research infrastructure developed during previous COBRE funding. Our COBRE funded Center for Molecular Medicine has had a number of successes. During the previous funding period 30 junior faculty from 12 different departments and centers were funded as COBRE project or pilot grant PIs. These mentored faculty received 27 NIH ROI grants, 11 other NIH grants, and 41 other peer-reviewed extramural grants. The COBRE-supported junior faculty published more than 400 research papers. These and other successes can in large part be attributed to a strong mentoring program, excellent institutional support, and the availability of the scientific cores associated with the Center. For this application, we propose to transition the Center for Molecular Medicine and its three scientific cores to independence of NIH/NIGMS support and to enhance and upgrade core technologies. It is worth noting that two of our original cores have or soon will transition to independence; the Proteomics core developed by this COBRE is now a University fee-for-service core, and the COBRE supported Imaging core is soon to become a department supported core. During the proposed five-year transition period we will increase the critical mass of faculty associated with the Center and continue to enhace its Cores. The use of vouchers will promote core usage and pilot grants will develop research collaborations and competitive grant submissions. The Administrative Core will serve as the focal point of the grant and in conjunction with the Program Coordinator and Internal Advisory Committee will serve as the operational arm of the Center. An External Advisory Committee, consisting of world-renown scientists will provide ongoing assessment and evaluation of the Center. Continuing Institutional commitments will ensure programmatic growth, and long-term sustainability.

COBRE III 期提案旨在进一步发展大学分子医学中心 肯塔基州。该中心专注于旨在了解分子机制的研究 与人类疾病相关，重点是癌症、神经退行性疾病、糖尿病和 心血管疾病。我们建议将开发的研究基础设施过渡到独立 在之前的 COBRE 融资期间。我们 COBRE 资助的分子医学中心拥有许多 成功。在上一个资助期间，来自 12 个不同部门和中心的 30 名初级教师 作为 COBRE 项目或试点拨款 PI 提供资金。这些受指导的教师获得了 27 项 NIH ROI 资助，11 项 其他 NIH 拨款，以及其他 41 项同行评审的校外拨款。 COBRE 支持的初级教师 发表研究论文400余篇。这些和其他成功在很大程度上可以归因于 强有力的指导计划、优秀的机构支持以及科学核心的可用性 与中心有关联。对于此应用，我们建议将分子医学中心转变为 及其三个科学核心独立于 NIH/NIGMS 支持并增强和升级核心 技术。值得注意的是，我们原有的两个核心已经或即将过渡到独立； 该 COBRE 开发的蛋白质组学核心现在是大学收费服务核心，并且 COBRE 支持的成像核心很快将成为部门支持的核心。在拟议的五年内 过渡期间，我们将增加与中心相关的教职人员数量，并继续 增强其核心。优惠券的使用将促进核心使用，试点赠款将发展研究 合作和竞争性赠款提交。行政核心将作为 赠款并与项目协调员和内部咨询委员会一起作为 中心的运营部门。由世界知名科学家组成的外部咨询委员会将 提供对中心的持续评估和评价。持续的机构承诺将确保 计划性增长和长期可持续性。