COBRE for the Center for Molecular Medicine
COBRE 分子医学中心
基本信息
- 批准号:9317707
- 负责人:
- 金额:$ 19.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAdvisory CommitteesAgingAnatomyAreaBiochemistryCancer CenterCardiovascular DiseasesCenters of Research ExcellenceClinicalCollaborationsCore FacilityDepartment chairDevelopmentDiabetes MellitusEnsureEvaluationExtramural ActivitiesFacultyFee-for-Service PlansFundingGoalsGrantGrowthGrowth and Development functionImageImmunologyInstitutionInstructionInternal MedicineKentuckyMalignant NeoplasmsMedicineMentorsMicrobiologyMolecularMolecular GeneticsMolecular MedicineNational Institute of General Medical SciencesNeurobiologyNeurodegenerative DisordersOrganic SynthesisPaperPathologyPatientsPediatricsPeer ReviewPharmacologyPhasePhysiologyPilot ProjectsPositioning AttributeProteinsProteomicsPsychiatryPublishingReadinessResearchResearch InfrastructureResearch PersonnelResearch SupportResourcesScientistSignal TransductionStagingTechnologyToxicologyTranslational ResearchTranslationsUnited States National Institutes of HealthUniversitiesWorkarmbaseclinical practicecollegefaculty mentorgenetic technologyhuman diseasemid-career facultyprogramssuccesstherapeutic targetvoucher
项目摘要
This COBRE Phase III proposal aims to further develop the Center for Molecular Medicine at the University
of Kentucky. This Center focuses on research aimed at understanding the molecular mechanisms
associated with human disease with emphases on cancer, neurodegenerative diseases, diabetes, and
cardiovascular diseases. We propose to transition to independence the research infrastructure developed
during previous COBRE funding. Our COBRE funded Center for Molecular Medicine has had a number of
successes. During the previous funding period 30 junior faculty from 12 different departments and centers
were funded as COBRE project or pilot grant PIs. These mentored faculty received 27 NIH ROI grants, 11
other NIH grants, and 41 other peer-reviewed extramural grants. The COBRE-supported junior faculty
published more than 400 research papers. These and other successes can in large part be attributed to a
strong mentoring program, excellent institutional support, and the availability of the scientific cores
associated with the Center. For this application, we propose to transition the Center for Molecular Medicine
and its three scientific cores to independence of NIH/NIGMS support and to enhance and upgrade core
technologies. It is worth noting that two of our original cores have or soon will transition to independence;
the Proteomics core developed by this COBRE is now a University fee-for-service core, and the COBRE
supported Imaging core is soon to become a department supported core. During the proposed five-year
transition period we will increase the critical mass of faculty associated with the Center and continue to
enhace its Cores. The use of vouchers will promote core usage and pilot grants will develop research
collaborations and competitive grant submissions. The Administrative Core will serve as the focal point of
the grant and in conjunction with the Program Coordinator and Internal Advisory Committee will serve as the
operational arm of the Center. An External Advisory Committee, consisting of world-renown scientists will
provide ongoing assessment and evaluation of the Center. Continuing Institutional commitments will ensure
programmatic growth, and long-term sustainability.
这项科布雷第三阶段提案旨在进一步发展该大学的分子医学中心
肯塔基州。该中心专注于旨在了解分子机制的研究
与人类疾病有关,重点是癌症、神经退行性疾病、糖尿病和
心血管疾病。我们建议将开发的研究基础设施过渡到独立
在之前的科布雷投资中。我们科布雷资助的分子医学中心已经有了一些
成功。在之前的资助期间,来自12个不同部门和中心的30名初级教员
被资助为科布雷项目或试点赠款个人投资项目。这些被指导的教职员工获得了27项NIH ROI拨款,11项
NIH的其他赠款,以及其他41项同行审查的校外赠款。科布雷资助的初级教员
发表研究论文400余篇。这些和其他的成功在很大程度上可以归因于
强大的指导计划,出色的机构支持,以及科学核心的可用性
与中心相关联。对于这一应用,我们建议将分子医学中心
及其三大科学核心对NIH/NIGMS的独立支持以及对核心的增强和升级
技术。值得注意的是,我们原来的两个核心已经或即将过渡到独立;
由这个Cobre开发的蛋白质组学核心现在是大学收费服务核心,Cobre
支持的成像核心即将成为部门支持的核心。在拟议的五年计划期间
在过渡期内,我们将增加与该中心相关的临界教职员工数量,并继续
加强它的核心。代金券的使用将促进核心使用,试点赠款将发展研究
合作和竞争性拨款申请。行政核心将作为以下工作的重点
赠款并与方案协调员和内部咨询委员会一起,将作为
该中心的运营部门。一个由世界知名科学家组成的外部咨询委员会将
提供对中心的持续评估和评估。持续的机构承诺将确保
计划性增长和长期可持续性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Louis B. Hersh其他文献
The Effect of Aliphatic Alcohols and Organic Solvents on Reactions Catalyzed by 5-Hydroxy-<em>N</em>-methylpyroglutamate Synthetase
- DOI:
10.1016/s0021-9258(19)45846-8 - 发表时间:
1971-12-25 - 期刊:
- 影响因子:
- 作者:
Louis B. Hersh - 通讯作者:
Louis B. Hersh
<em>N</em>-Methylglutamate Synthetase: THE USE OF FLAVIN MONONUCLEOTIDE IN OXIDATIVE CATALYSIS
- DOI:
10.1016/s0021-9258(19)43413-3 - 发表时间:
1973-10-10 - 期刊:
- 影响因子:
- 作者:
Robert J. Pollock;Louis B. Hersh - 通讯作者:
Louis B. Hersh
Effect of Vitamin B<sub>12</sub> Deprivation on the <em>in Vivo</em> Levels of Coenzyme A Intermediates Associated with Propionate Metabolism
- DOI:
10.1016/s0021-9258(19)42155-8 - 发表时间:
1974-11-10 - 期刊:
- 影响因子:
- 作者:
Eugene P. Frenkel;Richard L. Kitchens;Louis B. Hersh;Rene Frenkel - 通讯作者:
Rene Frenkel
Methylamine metabolism in a pseudomonas species.
假单胞菌属中的甲胺代谢。
- DOI:
- 发表时间:
1972 - 期刊:
- 影响因子:3.9
- 作者:
E. Bellion;E. Bellion;Louis B. Hersh;Louis B. Hersh - 通讯作者:
Louis B. Hersh
5-Hydroxy-<em>N</em>-methylpyroglutamate Synthetase: EVIDENCE FOR AN α-KETOGLUTARYL ENZYME INTERMEDIATE FROM PARTITIONING STUDIES
- DOI:
10.1016/s0021-9258(19)45917-6 - 发表时间:
1971-11-25 - 期刊:
- 影响因子:
- 作者:
Louis B. Hersh - 通讯作者:
Louis B. Hersh
Louis B. Hersh的其他文献
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{{ truncateString('Louis B. Hersh', 18)}}的其他基金
Insulin Degrading Enzyme: Physiological Function and its Spatial and Activity Modulation
胰岛素降解酶:生理功能及其空间和活性调节
- 批准号:
10216310 - 财政年份:2019
- 资助金额:
$ 19.79万 - 项目类别:
Insulin Degrading Enzyme: Physiological Function and its Spatial and Activity Modulation
胰岛素降解酶:生理功能及其空间和活性调节
- 批准号:
9817333 - 财政年份:2019
- 资助金额:
$ 19.79万 - 项目类别:
Insulin Degrading Enzyme: Physiological Function and its Spatial and Activity Modulation
胰岛素降解酶:生理功能及其空间和活性调节
- 批准号:
10453700 - 财政年份:2019
- 资助金额:
$ 19.79万 - 项目类别:
Neprilysin and Peripheral Clearance of Amyloid Peptides
脑啡肽酶和淀粉样肽的外周清除
- 批准号:
7858439 - 财政年份:2009
- 资助金额:
$ 19.79万 - 项目类别:
Center for Biomedical Research Excellence in the Molecular Basis of Human Disease
人类疾病分子基础卓越生物医学研究中心
- 批准号:
7919742 - 财政年份:2009
- 资助金额:
$ 19.79万 - 项目类别:
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