COBRE for the Center for Molecular Medicine

COBRE 分子医学中心

• 批准号: 8881234
• 负责人: Louis B. Hersh
• 金额: $ 112.81万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8881234
• 关键词: COBRE; Center; Molecular; Medicine

DESCRIPTION (provided by applicant): This COBRE Phase III proposal aims to further develop the Center for Molecular Medicine at the University of Kentucky. This Center focuses on research aimed at understanding the molecular mechanisms associated with human disease with emphases on cancer, neurodegenerative diseases, diabetes, and cardiovascular diseases. We propose to transition to independence the research infrastructure developed during previous COBRE funding. Our COBRE funded Center for Molecular Medicine has had a number of successes. During the previous funding period 30 junior faculty from 12 different departments and centers were funded as COBRE project or pilot grant PIs. These mentored faculty received 27 NIH ROI grants, 11 other NIH grants, and 41 other peer-reviewed extramural grants. The COBRE-supported junior faculty published more than 400 research papers. These and other successes can in large part be attributed to a strong mentoring program, excellent institutional support, and the availability of the scientific cores associated with the Center. For this application, we propose to transition the Center for Molecular Medicine and its three scientific cores to independence of NIH/NIGMS support and to enhance and upgrade core technologies. It is worth noting that two of our original cores have or soon will transition to independence; the Proteomics core developed by this COBRE is now a University fee-for-service core, and the COBRE supported Imaging core is soon to become a department supported core. During the proposed five-year transition period we will increase the critical mass of faculty associated with the Center and continue to enhace its Cores. The use of vouchers will promote core usage and pilot grants will develop research collaborations and competitive grant submissions. The Administrative Core will serve as the focal point of the grant and in conjunction with the Program Coordinator and Internal Advisory Committee will serve as the operational arm of the Center. An External Advisory Committee, consisting of world-renown scientists will provide ongoing assessment and evaluation of the Center. Continuing Institutional commitments will ensure programmatic growth, and long-term sustainability.

描述(由申请人提供)：这项科布雷第三阶段提案旨在进一步发展肯塔基大学的分子医学中心。该中心致力于研究与人类疾病相关的分子机制，重点研究癌症、神经退行性疾病、糖尿病和心血管疾病。我们建议将之前Cobre资助期间开发的研究基础设施过渡到独立。我们由科布雷资助的分子医学中心已经取得了一些成功。在之前的资助期间，来自12个不同部门和中心的30名初级教员被资助为Cobre项目或试点资助个人投资项目。这些接受指导的教师获得了27项NIH ROI资助，11项其他NIH资助，以及41项其他同行评审的校外资助。科布雷资助的初级教员发表了400多篇研究论文。这些和其他成功在很大程度上可以归功于强大的指导计划、出色的机构支持以及与该中心相关的科学核心的可获得性。对于这一应用，我们建议将分子医学中心及其三个科学核心转变为独立于NIH/NIGMS的支持，并增强和升级核心技术。值得注意的是，我们最初的两个核心已经或即将过渡到独立； 这个Cobre开发的蛋白质组学核心现在是大学收费服务核心，Cobre支持的成像核心很快就会成为部门支持的核心。在拟议的五年过渡期内，我们将增加与该中心相关的临界教职员工数量，并继续加强其核心。代金券的使用将促进核心用途，试点赠款将发展研究合作和竞争性赠款提交。行政核心将作为赠款的协调中心，并将与方案协调员和内部咨询委员会一起作为中心的业务部门。一个由世界知名科学家组成的外部咨询委员会将对该中心进行持续的评估和评价。持续的机构承诺将确保方案增长和长期可持续性。