Genomics and Bioinformatics Core

基因组学已成为生物学中的一项核心技术，并将对未来在 与人类健康相关的基础和应用研究。NH-INBRE机构包括 致力于研究重要生物医学过程的非传统模型的教师 健康主要是通过它们的基因组揭示的与同源过程的联系 比较。事实上，NH-INBRE网络中许多最活跃的PUI研究小组 没有接受过分子生物学方面的培训，但他们的工作获得了重大的生物医学意义 通过基因组学的应用。 为了具有竞争力，研究项目需要具有成本效益的、最先进的 仪器设备在有效的管理计划下运行。在拟议的NH-INBRE中 基因组学核心，获得先进的仪器设备对于研究支持和 留用和招聘PUI和主办机构的教员。一种有效的运营 在NH-INBRE的背景下，基因组学核心设施不仅仅是提供访问机会的问题 工具，但必须伴随着广泛的培训和支持 实验设计和分子技术的应用。 为了满足NH-INBRE教职员工的基因组和生物信息学需求， 学术伙伴，我们提出两个具体目标。第一个目标是建立一个共享的 基因组学核心设施，专门为多学科研究提供密集支持 组。这将通过利用UNH的现有设施和通过 区域合作伙伴之间的合作，以带来尽可能广泛的平台多样性和 能够将基因组方法用于多学科研究计划的专业知识 生物医学相关性。第二个目标是提供培训，以确保NH-INBRE教师 区域合作伙伴将使用最好的实验设计和基因组方法 再加上适当的生物信息学分析。这将由 在世界卫生组织的支持下，举办了一系列基因组学讲习班 生物信息学核心。

Genomics has become a core technology in biology, and will be critical to future advances in both basic and applied research relevant to human health. NH-INBRE institutions include faculty working on non-traditional models of important biomedical processes that inform human health primarily through connections with homologous processes revealed by their genomic comparisons. In fact, many of the most active PUI research groups in the NH-INBRE network are not trained in molecular biology but their work gains significant biomedical relevance through the application of genomics. To be competitive, research programs require cost-effective, state-of-the-art instrumentation operated under an effective management plan. In the proposed NH-INBRE Genomics Core, access to advanced instrumentation is vital to research support and to the retention and recruitment of faculty at PUIs and host institutions. The operation of an effective genomics core facility in the context of the NH-INBRE is not simply a matter of providing access to the instrumentation but must be accompanied by extensive training and support for experimental design and the application of molecular technologies. To address the genomic and bioinformatics needs of the NH-INBRE faculty and Academic Partners, we propose two specific aims. The first aim is to establish a shared genomics core facility that specializes in intensive support of multidisciplinary research groups. This will be accomplished by leveraging existing facilities at UNH and through collaboration among regional partners to bring the broadest possible diversity of platforms and expertise to enable the use of genomic approaches to multidisciplinary research programs of biomedical relevance. The second aim is to deliver the training to ensure NH-INBRE faculty and regional partners will use the best experimental design and genomic approaches coupled with appropriate bioinformatics analyses. This will be accomplished by the implementation of a series of genomics workshops coordinated with support from the bioinformatics core.