Research Core

研究核心

• 批准号: 10179414
• 负责人: W Kelley THOMAS
• 金额: $ 27.93万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10179414
• 关键词: Address; Administrator; Adopted; Advocate; Award; Awareness; Basic Science; Biological Sciences; Biomedical Engineering; Biomedical Research; Centers of Research Excellence; Climate; Clinical; Clinical Research; Collaborations; Communication Research; Core Facility; Detection; Development; Diagnosis; Discipline; Drug Delivery Systems; Educational workshop; Engineering; Ensure; Environment; Faculty; Fostering; Funding; Future; Future Teacher; Goals; Health; Healthcare; Human; Image; Infrastructure; Institution; Interdisciplinary Study; Investments; Knowledge; Lead; Leadership; Light; Medical; Methods; Microscope; Mission; Monitor; New Hampshire; Outcome; Pathway interactions; Periodicity; Productivity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Roentgen Rays; Science; Scientist; Series; Speed; Spottings; Techniques; Technology; Tissue Engineering; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Work; clinical research site; commercialization; cost effective; design; effective therapy; faculty research; field trip; human disease; improved; instrumentation; interdisciplinary approach; medical schools; meetings; multidisciplinary; new technology; novel diagnostics; novel therapeutics; programs; skills; success; training opportunity; translational medicine

A major challenge in translating basic research discoveries into medical solutions is the difficulty in fostering multidisciplinary research strategies that integrate knowledge from disparate disciplines. This challenge is heightened at research institutions lacking affiliated medical schools and/or clinical research centers. The long-term goals of the proposal are to: (1) establish a COBRE at UNH that integrates bioengineering and biomedical science research; (2) significantly increase the number of externally funded research projects relevant to the missions of NIH; and (3) create a biomedical research environment that enables scientists to work collaboratively on multidisciplinary research projects that advance translational medicine. The objective of the Research Core is to address these goals by engaging new technologies and perspectives for translating basic research knowledge into solutions and enhancing opportunities for multidisciplinary research. It is our contention that reducing the barriers to adopting novel technologies and perspectives will increase the productivity and impact of the research programs for CIBBR investigators. The Research Core will provide the infrastructure, expertise, and support necessary for enabling the multidisciplinary research programs envisioned by CIBBR. The specific aims of the Research Core are to: Aim 1. Acquire state-of-the-art instrumentation within an established university core facility that encourages multidisciplinary collaborations and perspectives and sustainability of research infrastructure. Successful research requires cost-effective, state-of-the-art instrumentation operated under an effective, sustainable management plan to help ensure accurate results to cutting edge hypotheses. To enable the research proposed by the five CIBBR early stage investigators, we will acquire a confocal microscope and an X-ray photoelectron spectrometer. These acquisitions will leverage substantial University investments and will have a major, positive impact on the overall institutional research climate. Aim 2. Provide intentionally designed programs to encourage communication of research, acquisition of new multidisciplinary techniques and perspectives, and nurture future clinical and commercialization collaborations with regional partners. We will focus efforts on four specific opportunities: (a) promote development of multidisciplinary research perspectives by establishing “super- group” research meetings; (b) sponsor instrumentation workshops; (c) establish a university-wide seminar series on the topic of engineered advances in healthcare in conjunction with field trips to clinical sites or healthcare companies; and (d) refine and evolve the thematic focus of the CIBBR at annual research retreats. Having the capacity to support multidisciplinary and translational perspectives for CIBBR faculty will improve the participation of basic biomedical and bioengineering research programs at UNH in translational endeavors to advance diagnosis and treatment of human diseases.

将基础研究发现转化为医疗解决方案的一个主要挑战是难以培养 多学科的研究战略，整合不同学科的知识。这一挑战 在缺乏附属医学院和/或临床研究中心的研究机构中加剧。 该提案的长期目标是：（1）在联合国海地大学建立一个综合生物工程和 生物医学科学研究;（2）大幅增加外部资助的研究项目数量 与NIH的使命相关;（3）创造一个生物医学研究环境，使科学家能够 在推进转化医学的多学科研究项目上合作。的目标 研究核心是通过采用新技术和新视角来实现这些目标， 将基础研究知识转化为解决方案，并增加多学科研究的机会。是我们 减少采用新技术和新观点的障碍将增加 CIBBR研究人员的研究计划的生产力和影响。研究中心将提供 基础设施，专业知识和支持，使多学科研究计划所需的 由CIBBR设计。研究核心的具体目标是： 目标1.在已建立的大学核心设施内获得最先进的仪器， 鼓励多学科合作和研究的观点和可持续性 基础设施演进成功的研究需要具有成本效益的，最先进的仪器下操作， 有效、可持续的管理计划，以帮助确保尖端假设的准确结果。使 根据五位CIBBR早期研究人员提出的研究，我们将获得共聚焦显微镜， X射线光电子能谱仪这些收购将利用大学的大量投资， 将对整个机构的研究气候产生重大的积极影响。 目标二。提供有意设计的计划，以鼓励研究，收购， 新的多学科技术和观点，并培养未来的临床和 与区域合作伙伴的商业合作。我们将集中精力在四个具体的 机会：（a）通过建立“超级研究中心”， 小组”研究会议;（B）赞助仪器讲习班;（c）建立一个大学范围的研讨会 关于医疗保健工程进展主题的系列，以及对临床地点的实地考察，或 （d）在年度研究务虚会上完善和发展CIBBR的主题重点。 有能力支持CIBBR教师的多学科和翻译观点将提高 参与UNH的基础生物医学和生物工程研究项目的转化工作 以推进人类疾病的诊断和治疗。