Serotonin receptor signaling in the interpeduncular nucleus and nicotine withdrawal

脚间核中的血清素受体信号传导与尼古丁戒断

基本信息

项目摘要

Project Summary/Abstract While adverse health consequences of smoking make it the primary cause of preventable mortality in the world, current therapies for smoking cessation are minimally effective highlighting the need for a better understanding of the pathophysiology underlying nicotine addiction. Recent work has identified an understudied circuit, the habenulo-interpeduncular nucleus (Hb-IPN) axis, as a critical circuit in nicotine withdrawal symptoms. In particular, during nicotine withdrawal in mouse models, neurons within the IPN exhibit increased activity triggering both somatic (physical) withdrawal symptoms, as well as affective symptoms including increased anxiety. Although little is known regarding the neurotransmitter input and receptor signaling within the IPN that modulates neuronal activity, previous work and preliminary data indicate serotonergic neurons originating in the median raphe nucleus innervate the IPN. Thus, the goal of this R21 is to identify a role for IPN serotonin and serotonergic receptor signaling in nicotine withdrawal behaviors. Aim 1 will test the hypothesis that median raphe serotonergic neurons project to, and modulate the firing of IPN neurons via serotonin receptor signaling. This hypothesis will be tested using a combination of optogenetic, biophysical, molecular, and pharmacological approaches in acute midbrain slices. Aim 2 will test the hypothesis that activation of serotonergic inputs into the IPN in vivo will modulate somatic and/or affective nicotine withdrawal symptoms in a mouse model of nicotine dependence. This hypothesis will be tested using in vivo optogenetic approaches in combination with behavior and brain region specific drug infusions. It is anticipated that characterizing the role of serotonin in the IPN during nicotine withdrawal will lead to identification of novel serotonin receptor targets for smoking cessation.
项目总结/文摘

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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ANDREW R TAPPER其他文献

ANDREW R TAPPER的其他文献

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{{ truncateString('ANDREW R TAPPER', 18)}}的其他基金

A role for the interpeduncular nucleus in innate defensive behaviors
脚间核在先天防御行为中的作用
  • 批准号:
    10467285
  • 财政年份:
    2022
  • 资助金额:
    $ 20.52万
  • 项目类别:
A role for the interpeduncular nucleus in innate defensive behaviors
脚间核在先天防御行为中的作用
  • 批准号:
    10558615
  • 财政年份:
    2022
  • 资助金额:
    $ 20.52万
  • 项目类别:
The role of familiarity neurocircuitry in novelty seeking
熟悉性神经回路在寻求新奇事物中的作用
  • 批准号:
    10412983
  • 财政年份:
    2019
  • 资助金额:
    $ 20.52万
  • 项目类别:
The role of familiarity neurocircuitry in novelty seeking
熟悉性神经回路在寻求新奇事物中的作用
  • 批准号:
    9982286
  • 财政年份:
    2019
  • 资助金额:
    $ 20.52万
  • 项目类别:
The role of familiarity neurocircuitry in novelty seeking
熟悉性神经回路在寻求新奇事物中的作用
  • 批准号:
    10633147
  • 财政年份:
    2019
  • 资助金额:
    $ 20.52万
  • 项目类别:
The role of familiarity neurocircuitry in novelty seeking
熟悉性神经回路在寻求新奇事物中的作用
  • 批准号:
    9813921
  • 财政年份:
    2019
  • 资助金额:
    $ 20.52万
  • 项目类别:
The role of familiarity neurocircuitry in novelty seeking
熟悉性神经回路在寻求新奇事物中的作用
  • 批准号:
    10171833
  • 财政年份:
    2019
  • 资助金额:
    $ 20.52万
  • 项目类别:
Interpeduncular circuitry in stress-responsive behaviors and nicotine dependence
应激反应行为和尼古丁依赖的脚间回路
  • 批准号:
    10539997
  • 财政年份:
    2017
  • 资助金额:
    $ 20.52万
  • 项目类别:
The mesointerpeduncular circuit in anxiety and nicotine withdrawal
焦虑和尼古丁戒断中的中脚间回路
  • 批准号:
    10087907
  • 财政年份:
    2017
  • 资助金额:
    $ 20.52万
  • 项目类别:
Nicotine-Mediated behavioral Consequences of Nicotinic Receptor Upregulation
尼古丁介导的烟碱受体上调的行为后果
  • 批准号:
    8829812
  • 财政年份:
    2014
  • 资助金额:
    $ 20.52万
  • 项目类别:

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ACUTE NICOTINE ABSTINENCE IN ADOLESCENTS
青少年的急性尼古丁戒断
  • 批准号:
    2859316
  • 财政年份:
    1998
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    $ 20.52万
  • 项目类别:
ACUTE NICOTINE ABSTINENCE IN ADOLESCENTS
青少年的急性尼古丁戒断
  • 批准号:
    6182973
  • 财政年份:
    1998
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    $ 20.52万
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ACUTE NICOTINE ABSTINENCE IN ADOLESCENTS
青少年的急性尼古丁戒断
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    6388102
  • 财政年份:
    1998
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ACUTE NICOTINE ABSTINENCE IN ADOLESCENTS
青少年的急性尼古丁戒断
  • 批准号:
    2889591
  • 财政年份:
    1998
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月经期和急性戒烟时的抑郁症状
  • 批准号:
    7209380
  • 财政年份:
    1993
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Menstrual Phase and Depression Symptoms in Acute Smoking Abstinence
月经期和急性戒烟时的抑郁症状
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    1993
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Menstrual Phase and Depression Symptoms in Acute Smoking Abstinence
月经期和急性戒烟时的抑郁症状
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    7813791
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ACUTE ABSTINENCE FROM TOBACCO--ELECTROPHYSIOLOGICAL AND COGNITIVE SIGNS
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    3853769
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    $ 20.52万
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