ACUTE ABSTINENCE FROM TOBACCO--ELECTROPHYSIOLOGICAL AND COGNITIVE SIGNS

实验室的努力方向是量化 尼古丁戒断期间的认知和表现缺陷， 用尼古丁口香糖治疗这些缺陷。 脑电图， 认知和认知过程在为期十天的监测期间， 重度吸烟者的戒烟。 一些变化持续了 整整十天的剥夺期 这些措施包括脑电图阿尔法 频率、θ功率、特定认知任务的绩效 （特别是快速算术任务）和与之相关的认知事件 电位测量（N100振幅）。刺激评估时间，如测量的 采用P300潜伏期和刺激深度评价成套测验， 在烟草剥夺期早期受到影响，但在 吸烟水平在剥夺期间后期。 因此，认知 在戒烟期间，缺陷明显， 有助于治疗期间复发。 撤退期间的赤字 至少有两个不同的组成部分-一个影响刺激 评价，5至7天的禁欲后消散， 影响注意力并伴有持续10天的低唤醒 或者更长。 在这一年中，对这些数据进行了分析， 提交出版。

The laboratory's efforts were directed toward the quantification of the cognitive and performance deficits during nicotine withdrawal and the treatment of these deficits with nicotine chewing gum. The EEG, cognitive, and cognitive process was monitored during a ten-day period of tobacco withdrawal in heavy smokers. Some of the changes persisted over the entire ten-day deprivation period. These measures included EEG alpha frequency, theta power, performance on selected cognitive tasks (especially a rapid arithmetic task) and a cognitive event related potential measure (N100 amplitude). Stimulus evaluation time, as measured by P300 latency, and the depth of stimulus evaluation battery were affected early during the tobacco deprivation period, but returned to smoking levels later during the deprivation period. Thus, the cognitive deficits are clearly apparent during abstinence from tobacco and contribute to relapse during treatment. The deficits during withdrawal have at least two different components - one affecting stimulus evaluation which dissipates after 5 to 7 days of abstinence and one affecting attention accompanied by lower arousal which persists ten days or longer. During the year this data was analyzed and two papes were submitted for publication.