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The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)

基于神经科学的心理健康评估和预测中心 (NEUROMAP)

基本信息

批准号：
9210848
负责人：
MARTIN P. PAULUS
金额：
$ 239.78万
依托单位：
LAUREATE INSTITUTE FOR BRAIN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9210848
关键词：
Address Affect Aftercare Anorexia Nervosa Anxiety Anxiety Disorders Award Base of the Brain Behavioral Bioinformatics Biological Biological Assay Biological Markers Biological Process Biological Psychiatry Biological Sciences Brain Brain imaging Cells Centers of Research Excellence Chicago Clinical Clinics and Hospitals Complex Core Facility Country Databases Desire for food Development Disease Eating Disorders Electrocardiogram Electroencephalography Exposure to Extinction (Psychology)Extramural Activities Functional Magnetic Resonance Imaging Functional disorder Funding Future Goals Illinois Individual Individual Differences Inflammatory Inpatients Institutes Laboratories Machine Learning Magnetic Resonance Imaging Major Depressive Disorder Measures Mental Depression Mental Health Mental disorders Mentors Midwestern United States Modeling Mood Disorders Moods National Institute of Mental Health Neuraxis Neurosciences Oklahoma Outcome Outpatients Patient Recruitments Patients Peer Review Phase Pilot Projects Population Process Productivity Psychiatric therapeutic procedure Psychiatrist Psychiatry Recruitment Activity Reporting Research Research Infrastructure Research Institute Research Personnel Research Project Grants Risk Role Schizophrenia Signal Transduction Standardization Stimulus Symptoms Technical Expertise Techniques Time United States National Institutes of Health Universities base brain research career development conditioned fear experimental study habituation health practice improved infrastructure development innovation insight motivated behavior multidisciplinary multimodality neuroimaging novel diagnostics outcome prediction predicting response programs relating to nervous system response statistics tool

项目摘要

Project Summary Mood and anxiety disorders will account for approximately $16 x 109 lost productivity or 25% of global GDP over the next 20 years. Eating disorders are among the deadliest psychiatric diseases and Anorexia Nervosa is two to three times more deadly than schizophrenia, bipolar and major depressive disorder. The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) aims to provide a (a) scientific, (b) operational, and (c) educational infrastructure for innovative neuroscience-based research to use individual differences on several biological levels together with sophisticated statistical approaches to generate clinically meaningful predictions of risk and outcomes for mood, anxiety, and eating disorders. The Laureate Institute for Brain Research (LIBR) in Tulsa, OK, is ideally placed to provide this infrastructure because: (a) LIBR has recruited young investigators with an impressive track record of scientific productivity, (b) LIBR is situated adjacent to the Laureate Psychiatric Clinic and Hospital (LPCH), one of the Midwest's largest psychiatric facilities that provides LIBR with a pipeline for patient recruitment, and (c) LIBR closely collaborates with the University of Tulsa (TU) on computational statistics and University of Oklahoma, Tulsa (OU) on bioassay research. The Specific Aims of NeuroMAP are: (1) To provide a state of the art neuroimaging and laboratory infrastructure to conduct biological experiments with multi-level assessments using core facilities; (2) To provide a mentoring infrastructure to a group of young investigators to conduct studies that identify predictive biological markers and processes for patients with mood or anxiety disorders; (3) To create a career development infrastructure to accelerate the investigator's transition from young investigator to established investigator; (4) To build an operational infrastructure that provides the tools necessary to conduct the research projects, standardize assessments and provide a data repository for future pilot projects. NeuroMAP will consists of: (a) an Administrative Core (Paulus): to establish the infrastructure necessary to expand the research efforts of the young investigators; (b) Research Core (Bodurka, Teague, McKinney): to provide the technical expertise to utilize multi-level approaches (from cell markers to symptoms) to quantify individual differences and generate outcome predictions. The Center proposes 5 different projects: (1) Cerebellar Role In Fear Conditioning And Extinction. (Cha) Mentor: Amit Etkin, Stanford; (2) Predicting Response To Exposure Therapy In Anxiety Disorders Using Neural And Behavioral Markers Of Interoceptive Habituation (Feinstein) Mentor: Murray Stein, UCSD; (3) Interoceptive dysfunction and Appetite Dysregulation in Depression (Simmons) Mentor: Luan Phan, University of Illinois Chicago; (4) Response To Inflammatory Challenge In Major Depressive Disorder (Savitz) Mentor: Mike Irwin, UCLA; (5) Dysfunctional Interoceptive Accuracy In Anorexia Nervosa, (Khalsa) Mentor: Walt Kaye, UCSD.

项目总结