The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)

项目总结：总体 到目前为止，情绪和焦虑障碍是世界上最普遍和最令人丧失能力的精神健康疾病 可用于这些情况的解释性和预测性疾病模型有限。这次会议的主题是 基于神经科学的心理健康评估和预测(NeuroMAP)Cobre是基于这样一个前提 使用跨诊断方法(即，跨越疾病的过程)的实验设计 类别)，具有多层次的分析(症状和行为、电路和生理、细胞和分子) 可以确定可成为干预目标的疾病修改过程。NeuroMAP的第一阶段 招募了8名RPL和8名PPI。截至2022年6月，他们申请了99项校外拨款，获得了8项联邦拨款， 并发表了130篇与P20相关的论文。使用NeuroMAP的两名代表性不足的少数族裔调查人员 核心数据获得享有盛誉的最大限度的科学和学术独立职业机会 (马赛克)K99/R00奖项。在NeuroMAP Cobre(2017年9月15日资助)之前，NIH的年度资金用于 LIBR为662,104美元(NIH记者2022年6月17日访问)，2021/22年度的年度资金为7,555,510美元 (5,368,214美元，不包括科布雷)，这是11.4(8.1)倍的增长。NeuroMAP第二阶段的目标 是维护和扩大RPL的基础设施。NeuroMAP的具体目标是：(1)扩展 关注基于神经科学的心理健康评估和心理健康评估的研究人员的临界数量 情绪和焦虑症的预测方法。(2)提供可运营的基础设施 提供进行研究项目、标准化评估和提供数据所需的工具 未来试点项目的储存库。(3)为青少年提供辅导和职业发展的基础设施 研究人员将重点研究情绪或焦虑的有针对性的疾病改善过程 精神错乱。NeuroMAP将包括：(A)行政核心(Paulus)；征聘和评估 核心(Aupperle&Khalsa)、电路和分子核心(Rohan&Savitz)以及数据管理和 统计核心(Kuplicki&Thompson)。建议的项目有三个：(1)经颅直流电 刺激：威胁敏感目标(Ironside)-外部导师：Monique Ernst，NIMH；内部导师： 罗宾·奥珀尔，LIBR。(2)厌恶内感状态对计算的影响及其相关 回避行为的神经基础(史密斯)-外部导师：菲利普·科利特，耶鲁大学；内部导师： 詹妮弗·斯图尔特，LIBR。(3)青少年重复性消极思维相关脑网络的调节 患有抑郁症(Tuchiyagaito)-外部导师：密歇根大学凯特·菲茨杰拉德；内部导师： 乔纳森·萨维茨，LIBR。第二阶段的目标是扩大对情绪和焦虑症的研究，建立 更大的资助调查人员基础，并吸引更多的年轻人才来描绘 有助于个人发展，从情绪和焦虑症中恢复和复发。

PROJECT SUMMARY: Overall Mood and Anxiety Disorders are the most prevalent and disabling mental health conditions worldwide, yet there are limited explanatory and predictive disease models available for these conditions. The theme of the Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE is based on the premise that experimental designs that use transdiagnostic approaches (i.e., processes that cut across disease categories) with multiple levels of analyses (symptoms & behavior, circuits & physiology, cells & molecules) can identify disease modifying processes that can become targets of interventions. Phase I of NeuroMAP recruited 8 RPLs and 8 PPIs. As of 6/2022, they applied for 99 extramural grants, received 8 federal grants, and published 130 papers linked to the P20. Two underrepresented minority investigators using NeuroMAP Core data received prestigious Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) K99/R00 awards. Prior to the NeuroMAP CoBRE (funded 9/15/2017) the annual NIH funding for LIBR was $662,104 (NIH Reporter accessed 6/17/2022), for 2021/22 the annual funding is $7,555,510 ($5,368,214 without the CoBRE), which is a 11.4 (8.1)-fold increase. The goal for Phase II of the NeuroMAP is to maintain and expand the infrastructure for RPLs. The Specific Aims of NeuroMAP are: (1) To expand the critical mass of investigators that are focused on Neuroscience-based Mental Health Assessment and Prediction approaches to mood and anxiety disorders. (2) To provide an operational infrastructure that provides the tools necessary to conduct research projects, standardize assessments, and provide a data repository for future pilot projects. (3) To provide a mentoring and career development infrastructure to junior investigators to conduct studies focused on targetable, disease modifying processes in mood or anxiety disorders. NeuroMAP will consists of: (a) an Administrative Core (Paulus); a Recruitment and Assessment Core (Aupperle & Khalsa), a Circuit and Molecules Core (Rohan & Savitz), and a Data Management and Statistics Core (Kuplicki & Thompson). There are three proposed projects: (1) Transcranial Direct Current Stimulation: Threat Sensitivity target (Ironside) - External Mentor: Monique Ernst, NIMH; Internal Mentor: Robin Aupperle, LIBR. (2) The effects of aversive interoceptive states on the computations and associated neural basis of avoidance behavior (Smith) - External Mentor: Philip Corlett, Yale University; Internal Mentor: Jennifer Stewart, LIBR. (3) Modulating repetitive negative thinking related brain networks in young adults with depression (Tsuchiyagaito) - External Mentor: Kate Fitzgerald, University of Michigan; Internal Mentor: Jonathan Savitz, LIBR. The goal of Phase II is to expand research in mood and anxiety disorders, build a bigger base of funded investigators, and to attract more young talent to delineate the processes that contribute to individuals developing, recovering from, and relapsing to mood and anxiety disorders.