The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)

基于神经科学的心理健康评估和预测中心 (NeuroMAP)

• 批准号: 10711134
• 负责人: MARTIN P. PAULUS
• 金额: $ 251.23万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711134
• 关键词: Anxiety; Anxiety Disorders; Area; Arizona; Award; Behavior; Biological; Brain; Categories; Cells; Computer Models; Country; Data; Databases; Diffusion Magnetic Resonance Imaging; Disease; Disease model; Emotional; Environment; Experimental Designs; Extramural Activities; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Grant; Image; Individual; Infrastructure; Intervention; Laboratories; Left; Link; Medical; Mental Depression; Mental Health; Mental disorders; Mentally Disabled Persons; Mentors; Michigan; Mood Disorders; Myelin; National Institute of Mental Health; Neurosciences; Oklahoma; Paper; Phase; Physiology; Pilot Projects; Postdoctoral Fellow; Prefrontal Cortex; Process; Publishing; Recurrence; Relapse; Reporter; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Robin bird; Services; Severities; South Carolina; Standardization; Symptoms; Talents; Thinking; Time; Training; Underrepresented Minority; United States National Institutes of Health; Universities; adaptive immunity; anxious individuals; avoidance behavior; base; career; career development; comorbidity; data management; data repository; diagnostic strategy; exosome; health assessment; improved; infrastructure development; language processing; minority investigator; neural; neurofeedback; neuroimaging; programs; recruit; statistics; tool; transcranial direct current stimulation; young adult

PROJECT SUMMARY: Overall Mood and Anxiety Disorders are the most prevalent and disabling mental health conditions worldwide, yet there are limited explanatory and predictive disease models available for these conditions. The theme of the Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE is based on the premise that experimental designs that use transdiagnostic approaches (i.e., processes that cut across disease categories) with multiple levels of analyses (symptoms & behavior, circuits & physiology, cells & molecules) can identify disease modifying processes that can become targets of interventions. Phase I of NeuroMAP recruited 8 RPLs and 8 PPIs. As of 6/2022, they applied for 99 extramural grants, received 8 federal grants, and published 130 papers linked to the P20. Two underrepresented minority investigators using NeuroMAP Core data received prestigious Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) K99/R00 awards. Prior to the NeuroMAP CoBRE (funded 9/15/2017) the annual NIH funding for LIBR was $662,104 (NIH Reporter accessed 6/17/2022), for 2021/22 the annual funding is $7,555,510 ($5,368,214 without the CoBRE), which is a 11.4 (8.1)-fold increase. The goal for Phase II of the NeuroMAP is to maintain and expand the infrastructure for RPLs. The Specific Aims of NeuroMAP are: (1) To expand the critical mass of investigators that are focused on Neuroscience-based Mental Health Assessment and Prediction approaches to mood and anxiety disorders. (2) To provide an operational infrastructure that provides the tools necessary to conduct research projects, standardize assessments, and provide a data repository for future pilot projects. (3) To provide a mentoring and career development infrastructure to junior investigators to conduct studies focused on targetable, disease modifying processes in mood or anxiety disorders. NeuroMAP will consists of: (a) an Administrative Core (Paulus); a Recruitment and Assessment Core (Aupperle & Khalsa), a Circuit and Molecules Core (Rohan & Savitz), and a Data Management and Statistics Core (Kuplicki & Thompson). There are three proposed projects: (1) Transcranial Direct Current Stimulation: Threat Sensitivity target (Ironside) - External Mentor: Monique Ernst, NIMH; Internal Mentor: Robin Aupperle, LIBR. (2) The effects of aversive interoceptive states on the computations and associated neural basis of avoidance behavior (Smith) - External Mentor: Philip Corlett, Yale University; Internal Mentor: Jennifer Stewart, LIBR. (3) Modulating repetitive negative thinking related brain networks in young adults with depression (Tsuchiyagaito) - External Mentor: Kate Fitzgerald, University of Michigan; Internal Mentor: Jonathan Savitz, LIBR. The goal of Phase II is to expand research in mood and anxiety disorders, build a bigger base of funded investigators, and to attract more young talent to delineate the processes that contribute to individuals developing, recovering from, and relapsing to mood and anxiety disorders.

项目概述：

项目成果

Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.

• DOI: 10.1159/000528377
• 发表时间: 2023
• 期刊: PSYCHOTHERAPY AND PSYCHOSOMATICS
• 影响因子: 22.8
• 作者: Tsuchiyagaito, Aki;Misaki, Masaya;Kirlic, Namik;Yu, Xiaoqian;Sanchez, Stella M.;Cochran, Gabe;Stewart, Jennifer L.;Smith, Ryan;Fitzgerald, Kate D.;Rohan, Michael L.;Paulus, Martin P.;Guinjoan, Salvador M.
• 通讯作者: Guinjoan, Salvador M.

Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach-avoidance conflict: a replication study.

• DOI: 10.1503/jpn.220226
• 发表时间: 2023-05
• 期刊: JOURNAL OF PSYCHIATRY & NEUROSCIENCE
• 影响因子: 4.3
• 作者: Smith, Ryan;Lavalley, Claire A.;Taylor, Samuel;Stewart, Jennifer L.;Khalsa, Sahib S.;Berg, Hannah;Ironside, Maria;Paulus, Martin P.;Aupperle, Robin
• 通讯作者: Aupperle, Robin

Automated pipeline for EEG artifact reduction (APPEAR) recorded during fMRI.

• DOI: 10.1088/1741-2552/ac1037
• 发表时间: 2021-07-26
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: Mayeli A;Al Zoubi O;Henry K;Wong CK;White EJ;Luo Q;Zotev V;Refai H;Bodurka J
• 通讯作者: Bodurka J

Reduced immunity to measles in adults with major depressive disorder.

• DOI: 10.1017/s0033291718000661
• 发表时间: 2019-01
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Ford BN;Yolken RH;Dickerson FB;Teague TK;Irwin MR;Paulus MP;Savitz J
• 通讯作者: Savitz J

The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial.

FAAH 抑制对健康男性受试者焦虑相关处理的神经基础的影响：一项随机临床试验。

• DOI: 10.1038/s41386-020-00936-w
• 发表时间: 2021
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Paulus,MartinP;Stein,MurrayB;Simmons,AlanN;Risbrough,VictoriaB;Halter,Robin;Chaplan,SandraR
• 通讯作者: Chaplan,SandraR