The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)

项目总结：总体 情绪和焦虑障碍是世界上最普遍和最致残的心理健康状况， 可用于这些病症的解释性和预测性疾病模型有限。的主题 基于神经科学的心理健康评估和预测（NeuroMAP）CoBRE基于以下前提： 使用转诊断方法的实验设计（即，跨越疾病的过程 类别）与多层次的分析（症状和行为，电路和生理，细胞和分子） 可以识别疾病的改变过程，这些过程可以成为干预的目标。NeuroMAP的第一阶段 招募了8名RPL和8名PPI。截至2022年6月，他们申请了99项校外赠款，获得了8项联邦赠款， 发表了130篇与P20有关的论文。两名代表性不足的少数民族研究者使用NeuroMAP 核心数据获得著名的最大化科学和学术独立职业的机会 （MOSAIC）K99/R 00奖项。在NeuroMAP CoBRE（2017年9月15日资助）之前，NIH每年资助 LIBR为662，104美元（NIH Reporter于2022年6月17日访问），2021/22年度资金为7，555，510美元 （5，368，214美元，不含CoBRE），增长了11.4（8.1）倍。NeuroMAP第二阶段的目标 是维护和扩大可重复使用许可证的基础设施。NeuroMAP的具体目的是：（1）扩展 专注于基于神经科学的心理健康评估的研究人员的临界质量， 情绪和焦虑症的预测方法。(2)提供一个业务基础设施， 提供了必要的工具，进行研究项目，标准化评估，并提供一个数据 未来试点项目的存储库。(3)为初级员工提供指导和职业发展基础设施 研究人员进行研究，重点是有针对性的，在情绪或焦虑的疾病修饰过程 紊乱NeuroMAP将包括：（a）管理核心（Paulus）;招募和评估 核心（Aupperle & Khalsa）、电路和分子核心（罗汉& Savitz）以及数据管理和 Statistics Core（Kuplicki & Thompson）.拟开展的项目有三个：（1）经颅直流电 刺激：威胁敏感度目标（Ironside）-外部导师：Monique Ernst，NIMH;内部导师： 罗宾·奥佩尔，伦敦银行研究所。(2)厌恶的内感受状态对计算的影响和相关的 回避行为的神经基础（Smith）-外部导师：Philip Corlett，耶鲁大学;内部导师： 詹妮弗·斯图尔特，LIBR。(3)调节年轻人的重复性消极思维相关脑网络 抑郁症（土屋盖人）-外部导师：密歇根大学凯特·菲茨杰拉德;内部导师： 乔纳森·萨维茨，伦敦银行研究所。第二阶段的目标是扩大情绪和焦虑症的研究，建立一个 更大的受资助调查人员基数，并吸引更多的年轻人才来描述 有助于个人发展，从情绪和焦虑症中恢复和复发。

PROJECT SUMMARY: Overall Mood and Anxiety Disorders are the most prevalent and disabling mental health conditions worldwide, yet there are limited explanatory and predictive disease models available for these conditions. The theme of the Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE is based on the premise that experimental designs that use transdiagnostic approaches (i.e., processes that cut across disease categories) with multiple levels of analyses (symptoms & behavior, circuits & physiology, cells & molecules) can identify disease modifying processes that can become targets of interventions. Phase I of NeuroMAP recruited 8 RPLs and 8 PPIs. As of 6/2022, they applied for 99 extramural grants, received 8 federal grants, and published 130 papers linked to the P20. Two underrepresented minority investigators using NeuroMAP Core data received prestigious Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) K99/R00 awards. Prior to the NeuroMAP CoBRE (funded 9/15/2017) the annual NIH funding for LIBR was $662,104 (NIH Reporter accessed 6/17/2022), for 2021/22 the annual funding is $7,555,510 ($5,368,214 without the CoBRE), which is a 11.4 (8.1)-fold increase. The goal for Phase II of the NeuroMAP is to maintain and expand the infrastructure for RPLs. The Specific Aims of NeuroMAP are: (1) To expand the critical mass of investigators that are focused on Neuroscience-based Mental Health Assessment and Prediction approaches to mood and anxiety disorders. (2) To provide an operational infrastructure that provides the tools necessary to conduct research projects, standardize assessments, and provide a data repository for future pilot projects. (3) To provide a mentoring and career development infrastructure to junior investigators to conduct studies focused on targetable, disease modifying processes in mood or anxiety disorders. NeuroMAP will consists of: (a) an Administrative Core (Paulus); a Recruitment and Assessment Core (Aupperle & Khalsa), a Circuit and Molecules Core (Rohan & Savitz), and a Data Management and Statistics Core (Kuplicki & Thompson). There are three proposed projects: (1) Transcranial Direct Current Stimulation: Threat Sensitivity target (Ironside) - External Mentor: Monique Ernst, NIMH; Internal Mentor: Robin Aupperle, LIBR. (2) The effects of aversive interoceptive states on the computations and associated neural basis of avoidance behavior (Smith) - External Mentor: Philip Corlett, Yale University; Internal Mentor: Jennifer Stewart, LIBR. (3) Modulating repetitive negative thinking related brain networks in young adults with depression (Tsuchiyagaito) - External Mentor: Kate Fitzgerald, University of Michigan; Internal Mentor: Jonathan Savitz, LIBR. The goal of Phase II is to expand research in mood and anxiety disorders, build a bigger base of funded investigators, and to attract more young talent to delineate the processes that contribute to individuals developing, recovering from, and relapsing to mood and anxiety disorders.