Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)

缩小尼日利亚北部儿童癫痫治疗差距 (BRIDGE)

基本信息

批准号：
9406559
负责人：
Muktar Hassan Aliyu
金额：
$ 19.36万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-11 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9406559
关键词：
Academic Medical Centers Africa South of the Sahara Age Antiepileptic Agents Area Caring Centers for Disease Control and Prevention (U.S.)Cessation of life Child Child Care Childhood Clinical Research Clinical Trials Clinical Trials Design Communities Community Health Aides Country Data Collection Developed Countries Developing Countries Diagnosis Diagnostic Education Electroencephalogram Environment Epilepsy Evaluation Family Foundations Friends Funding Future HIV Health Health Personnel Health Services Health Services Accessibility Improve Access International Intervention Knowledge Maps Measures Modeling Monitor Morbidity - disease rate Nigeria Nurses Patients Pediatric Neurology Physicians Privatization Qualitative Evaluations Research Resources Risk Rural Seizures Services Sickle Cell Anemia Specialist Stroke prevention Syndrome System Targeted Research Teaching Hospitals Testing Training Training Programs United States National Institutes of Health World Health Organization base care systems clinical care design global health improved improved outcome innovation low and middle-income countries mortality multidisciplinary nervous system disorder novel peer premature rural area satisfaction standard care urban area

项目摘要

Abstract Epilepsy is the most common serious neurological disorder among children worldwide, and approximately 80% of children with epilepsy live in low- and middle-income countries (LMICs), with increased morbidity and increased risk of death. Among children with epilepsy in LMICs, between 67% and 90% are not receiving consistent and appropriate treatment – a phenomena known as the epilepsy treatment gap. The millions of children with epilepsy living in LMICs have not benefited from the advances in epilepsy care over the past half-century, as the models of epilepsy care in rich countries are not easily adapted to the reality of resource- poor sub-Saharan Africa. “Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)” will establish a foundation upon which to perform larger definitive studies and clinical trials of innovative epilepsy care systems and therapies by (a) quantifying and mapping the childhood epilepsy treatment gap in Kano, Nigeria, (b) training, developing, and piloting task-shifted epilepsy care teams to improve epilepsy care access, and (c) developing and piloting innovative epilepsy diagnostic paradigms designed for low-resource environments with limited access to electroencephalograms (EEGs). To accomplish these aims we have assembled a strong multidisciplinary team representing Vanderbilt University Medical Center, Aminu Kano Teaching Hospital in Kano, Nigeria, and the BRIDGE Advisory Board- a multi-disciplinary team of experts focused on bridging the childhood epilepsy treatment gap. BRIDGE, and the clinical trials that will be built upon the BRIDGE foundation, have the potential to close the childhood epilepsy treatment gap in sub-Saharan Africa, and in poor communities around the world.

抽象的癫痫是全球儿童中最常见的严重神经系统疾病，大约 80％的癫痫儿童生活在低收入和中等收入国家（LMIC），发病率和增加增加死亡风险。在LMICS癫痫的儿童中，有67％至90％的儿童未接受一致且适当的治疗 - 一种称为癫痫治疗差距的现象。数百万居住在LMIC的癫痫病的孩子并没有从过去的癫痫护理进步中受益半个世纪，由于富裕国家的癫痫护理模型不容易适应资源的现实 - 撒哈拉以南非洲贫穷。 “弥合尼日利亚北部的儿童癫痫治疗差距（桥）”将建立一个基础在其中进行更大的确定性研究和创新癫痫护理系统的临床试验和通过（a）量化和映射尼日利亚卡诺的儿童癫痫治疗差距的治疗，（b）培训，开发和试行任务换档的癫痫护理团队以改善癫痫护理，并且（c）开发并驾驶专门为低资源环境设计的创新癫痫诊断范例访问脑电图（EEG）。为了实现这些目标，我们组装了一个强大的代表范德比尔特大学医学中心的多学科团队，Aminu Kano教学医院尼日利亚卡诺（Kano）和桥梁咨询委员会儿童癫痫治疗差距。桥梁以及将在桥上建造的临床试验基金会，有可能缩小撒哈拉以南非洲的儿童癫痫治疗差距世界各地贫穷的社区。