Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)

缩小尼日利亚北部儿童癫痫治疗差距 (BRIDGE)

• 批准号: 9406559
• 负责人: Muktar Hassan Aliyu
• 金额: $ 19.36万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-11 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9406559
• 关键词: Academic Medical Centers; Africa South of the Sahara; Age; Antiepileptic Agents; Area; Caring; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Care; Childhood; Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Community Health Aides; Country; Data Collection; Developed Countries; Developing Countries; Diagnosis; Diagnostic; Education; Electroencephalogram; Environment; Epilepsy; Evaluation; Family; Foundations; Friends; Funding; Future; HIV; Health; Health Personnel; Health Services; Health Services Accessibility; Improve Access; International; Intervention; Knowledge; Maps; Measures; Modeling; Monitor; Morbidity - disease rate; Nigeria; Nurses; Patients; Pediatric Neurology; Physicians; Privatization; Qualitative Evaluations; Research; Resources; Risk; Rural; Seizures; Services; Sickle Cell Anemia; Specialist; Stroke prevention; Syndrome; System; Targeted Research; Teaching Hospitals; Testing; Training; Training Programs; United States National Institutes of Health; World Health Organization; base; care systems; clinical care; design; global health; improved; improved outcome; innovation; low and middle-income countries; mortality; multidisciplinary; nervous system disorder; novel; peer; premature; rural area; satisfaction; standard care; urban area

Abstract Epilepsy is the most common serious neurological disorder among children worldwide, and approximately 80% of children with epilepsy live in low- and middle-income countries (LMICs), with increased morbidity and increased risk of death. Among children with epilepsy in LMICs, between 67% and 90% are not receiving consistent and appropriate treatment – a phenomena known as the epilepsy treatment gap. The millions of children with epilepsy living in LMICs have not benefited from the advances in epilepsy care over the past half-century, as the models of epilepsy care in rich countries are not easily adapted to the reality of resource- poor sub-Saharan Africa. “Bridging the Childhood Epilepsy Treatment Gap in Northern Nigeria (BRIDGE)” will establish a foundation upon which to perform larger definitive studies and clinical trials of innovative epilepsy care systems and therapies by (a) quantifying and mapping the childhood epilepsy treatment gap in Kano, Nigeria, (b) training, developing, and piloting task-shifted epilepsy care teams to improve epilepsy care access, and (c) developing and piloting innovative epilepsy diagnostic paradigms designed for low-resource environments with limited access to electroencephalograms (EEGs). To accomplish these aims we have assembled a strong multidisciplinary team representing Vanderbilt University Medical Center, Aminu Kano Teaching Hospital in Kano, Nigeria, and the BRIDGE Advisory Board- a multi-disciplinary team of experts focused on bridging the childhood epilepsy treatment gap. BRIDGE, and the clinical trials that will be built upon the BRIDGE foundation, have the potential to close the childhood epilepsy treatment gap in sub-Saharan Africa, and in poor communities around the world.

摘要 癫痫是全世界儿童中最常见的严重神经系统疾病， 80%的癫痫儿童生活在低收入和中等收入国家（LMICs），发病率增加， 增加死亡风险。在中低收入国家的癫痫儿童中，67%至90%的儿童没有接受 一致和适当的治疗-这种现象被称为癫痫治疗差距。数百万 生活在中低收入国家的癫痫儿童并没有从过去的癫痫护理进步中受益 半个世纪以来，由于富裕国家的癫痫护理模式不容易适应资源的现实， 贫穷的撒哈拉以南非洲。 “弥合北方尼日利亚儿童癫痫治疗差距”将建立一个基金会 在此基础上进行更大规模的确定性研究和创新癫痫护理系统的临床试验， （a）量化和绘制尼日利亚卡诺的儿童癫痫治疗差距，（B）培训， 开发和试点任务转移癫痫护理团队，以改善癫痫护理的可及性，以及（c）开发 并试点创新的癫痫诊断模式，专为低资源环境， 获取脑电图。为了实现这些目标，我们组建了一个强大的 代表范德比尔特大学医学中心，Aminu Kano教学医院的多学科团队 尼日利亚卡诺市，以及“桥”咨询委员会----一个多学科专家小组， 儿童癫痫治疗差距。BRIDGE，以及基于BRIDGE的临床试验 基金会，有可能缩小撒哈拉以南非洲儿童癫痫治疗的差距， 世界各地的贫困社区。