Vanderbilt-Nigeria Biostatistics Training Program (VN-BioStat)

项目摘要 在西非建设生物统计能力至关重要。生物医学艾滋病毒研究在西非正在增长，但 生物统计支助和专门知识滞后。在西非和美国之间的艾滋病毒合作研究中， 生物统计学的领导者几乎总是来自美国，发展生物统计学很重要。 西非的领导人-生物统计学家，他们不是技术人员，而是共同研究者，主要负责人 研究人员和受资助的艾滋病毒/艾滋病研究的思想领袖。有几个统计学博士课程， 西非，但他们往往很少或根本没有与生物医学研究。资助的培训举措 在过去的十年里，在南部非洲和东非建立生物统计学方面取得了成功，但没有 西非目前有这样的方案。 范德比尔特-尼日利亚生物统计学培训计划（VN-BioStat）建立在长期合作的基础上 尼日利亚和美国的两个主要研究机构，即Aminu Kano教学， 医院（AKTH）和范德比尔特大学医学中心（范德比尔特）建立了一个研究和培训 为在尼日利亚从事艾滋病毒相关研究的生物统计学家提供平台。VN-BioStat将建立在以下资源基础上： AKTH及其母公司，卡诺Bayero大学（布克），以创建一个高技能的尼日利亚队列 有能力领导和监督西非生物统计活动的生物统计人员。VN-BioStat 利用美国国立卫生研究院的高度成功、协作和迅速扩大的投资组合， 健康（NIH）和其他资助的研究在AKTH，与联合领导的范德比尔特研究人员。培养 作为尼日利亚的生物统计学家领导者，VN-BioStat计划建议将两名尼日利亚数据科学家， 一年（5年共10年）到范德比尔特沉浸在生物统计学和接受培训的手。 在为期一年的培训期间，学员将领导一个合作的设计，分析和出版， 使用AKTH的艾滋病毒数据的研究项目。他们还将领导一个相关的、以方法论为重点的项目 最终会出版在范德比尔特，他们将与一个艾滋病毒生物统计学家团队进行互动， 采取适当的生物统计学课程（最多8学分每学期2学期），参加生物统计学 和全球健康研讨会，参加赠款写作研讨会，参加生物统计诊所，并合作 与其他尼日利亚调查员他们将接受范德比尔特教师的指导（一名生物统计学家， 一名临床研究员）和AKTH教师。我们还将在尼日利亚举办年度研讨会， 为多达25名艾滋病毒研究人员提供生物统计学培训。潜在的课程主题包括解决以下问题的方法 缺失数据，因果推理介绍，回归建模策略，生物医学研究中的大数据， 生存分析。

PROJECT ABSTRACT It is critical to build biostatistics capacity in West Africa. Biomedical HIV research is growing in West Africa, but biostatistical support and expertise are lagging. In collaborative HIV studies between West Africa and U.S. institutions, the biostatistics leaders are almost always from the U.S. It is important to develop biostatistics leaders in West Africa – biostatisticians who will not be technicians, but co-investigators, principal investigators, and thought-leaders in funded HIV/AIDS research. There are several statistics PhD programs in West Africa, but they often have little or no connection with biomedical research. Funded training initiatives over the past ten years have been successful at building biostatistics in Southern Africa and East Africa, but no such programs currently exist in West Africa. The Vanderbilt-Nigeria Biostatistics Training Program (VN-BioStat) builds on long-standing collaborations between two leading research institutions in Nigeria and the United States, namely, Aminu Kano Teaching Hospital (AKTH) and Vanderbilt University Medical Center (Vanderbilt) to establish a research and training platform for biostatisticians doing HIV-related research in Nigeria. VN-BioStat will build upon the resources of AKTH and its parent institution, Bayero University in Kano (BUK), to create a cohort of highly skilled Nigerian biostatisticians with the capacity to lead and supervise biostatistical activities in West Africa. VN-BioStat leverages the highly successful, collaborative and rapidly expanding portfolio of U.S. National Institutes of Health (NIH) and other funded research at AKTH, with joint leadership from Vanderbilt investigators. To train biostatistician leaders in Nigeria, the VN-BioStat program proposes to bring two Nigerian data scientists per year (total of 10 over 5 years) to Vanderbilt to immerse them in biostatistics and to receive hands on training. During the one-year training period, trainees will lead the design, analysis, and publication of a collaborative research project using HIV data from AKTH. They will also lead a related, methodologically focused project that will culminate in a publication. While at Vanderbilt, they will interact with a team of HIV biostatisticians, take appropriate biostatistics courses (up to 8 credit hours per semester for 2 semesters), attend biostatistics and global health seminars, participate in a grant-writing workshop, attend biostatistics clinics, and collaborate with other Nigerian investigators. They will receive mentorship from Vanderbilt faculty (one biostatistician and one clinical investigator) and AKTH faculty. We will also conduct annual workshops in Nigeria to provide mid- level biostatistics training for up to 25 HIV researchers. Potential course topics include methods to address missing data, introduction to causal inference, regression modeling strategies, big data in biomedical research, and survival analysis.