2017 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

2017肌肉：兴奋-收缩耦合戈登研究会议暨戈登研究研讨会

• 批准号: 9331041
• 负责人: Hector H Valdivia
• 金额: $ 2.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331041
• 关键词: Addendum; Aging; Area; Atrophic; Back; Basic Science; British Columbia; Calcium Signaling; Career Mobility; Clinical; Clinical Research; Clinical Trials; Communication; Communities; Coupling; Crystallization; Defect; Development; Discipline; Disease; Elements; Environment; Functional disorder; Gender; Geographic Locations; Goals; Government; Growth; Health; Heart Diseases; Human; Individual; Industrialization; Inherited; Institutes; International; Knowledge; Lead; Leadership; Maine; Medical; Metabolic Diseases; Metabolism; Michigan; Molecular; Muscle; Muscle Fatigue; Mutation; Myocardium; Myopathy; Neuromuscular Diseases; Neurosciences; Outcome; Participant; Patients; Performance; Postdoctoral Fellow; Process; Quality of life; Race; Regulation; Research; Research Personnel; Resolution; Roentgen Rays; Ryanodine Receptor Calcium Release Channel; Scientist; Skeletal Muscle; Structure; Students; Switzerland; Time; Translational Research; Triad Acrylic Resin; Universities; Work; career; combat; effective therapy; experience; graduate student; improved; innovation; insight; meetings; new therapeutic target; news; novel strategies; novel therapeutics; posters; programs; public health relevance; sarcopenia; skeletal; success; symposium

ABSTRACT This is a proposal for partial support of the only major national and/or international meeting dedicated to excitation/contraction coupling and how defects in this critical process underlie muscle disease. The Muscle: Excitation-Contraction Coupling (ECC) Gordon Research Conference (GRC) will meet from June 4 – June 9, 2017 at Les Diablerets Conference Center in Les Diablerets, Switzerland. The GRC program was developed by an Executive Organizing Committee consisting of leaders in ECC research including Drs. Héctor H. Valdivia (University of Michigan), Isabelle Marty (Grenoble Institute of Neurosciences), and Filip Van Petegem (University of British Columbia). The two overarching objectives of the 2017 Muscle: Excitation-Contraction Coupling GRC are: Objective 1: To discuss and critically evaluate new breakthroughs regarding the molecular mechanisms that control ECC and how this process is altered in muscle fatigue, atrophy, sarcopenia, metabolic disease, and genetically-inherited forms of skeletal and cardiac muscle disease. Objective 2: To promote visibility and leadership of junior investigators in the field by providing a platform for students, postdoctoral fellows, and new independent investigators to present their work, as well as to interact and network with established senior investigators. The 2017 GRC conference will consist of ~30 speakers, ~18 Discussion Leaders, and ~13 poster presentations. Scientific sessions will focus on structural studies of the ECC apparatus, new insights into the molecular mechanisms and regulation of ECC, identification of new therapeutic targets, and the development of innovative treatments for muscle fatigue, sarcopenia, and skeletal and cardiac muscle disorders that adversely impact millions of individuals in the US. For the second time for this GRC, the meeting will be preceded by a two-day Gordon Research Seminar (GRS) for graduate students and postdoctoral fellows. In addition, for each session during the GRC a young investigator will be paired with a senior investigator to serve as Co-Discussion Leaders. Innovative “Poster Flash Sessions” and “This Just In” speaker slots will be used to highlight late-breaking news. These innovative program elements will also maximize poster session visibility, as well as to enhance the integration and exposure of promising young investigators in the field during the GRC. We expect that this conference will attract 150-200 basic and clinical scientists across all career stages, genders, races, heritages, research disciplines, professional affiliations (academic, industrial, government), and geographical locations. Our overall aim is to promote: 1) open dialogue and communication, 2) exposure and career advancement of promising young investigators in the field, 3) fundamental understanding in the mechanisms of ECC and how defects in this process lead to compromised skeletal and cardiac muscle performance, and 4) the development of novel and effective therapies to combat skeletal and cardiac muscle disorders.

摘要 这是一项部分支持唯一一次主要的国家和/或国际会议的建议， 兴奋/收缩耦合以及这个关键过程中的缺陷如何成为肌肉疾病的基础。肌肉： 激励-收缩耦合（ECC）戈登研究会议（GRC）将于6月4日至6月9日举行， 2017年，在瑞士Les Diablerets的Les Diablerets会议中心举行。GRC计划是在 由ECC研究领导人组成的执行组织委员会，包括Héctor H博士。瓦尔迪维亚 （密歇根大学），伊莎贝尔马蒂（格勒诺布尔神经科学研究所）和菲利普货车Petegem （不列颠哥伦比亚省大学）。2017年肌肉的两个首要目标：兴奋-收缩 耦合GRC是：目标1：讨论和批判性地评估新的突破， 控制ECC的分子机制以及该过程如何在肌肉疲劳，萎缩， 肌肉减少症、代谢性疾病和遗传性形式的骨骼肌和心肌疾病。 目标2：通过提供一个平台， 学生，博士后研究员和新的独立研究人员介绍他们的工作，以及互动 与资深调查员建立联系2017年GRC会议将由~30位演讲者，~18位 讨论领导人，和~13海报介绍。科学会议将侧重于结构研究的 ECC仪器，对ECC的分子机制和调节的新见解，新的 治疗目标，并开发用于肌肉疲劳、肌肉减少症和骨骼肌的创新治疗方法。 以及对美国数百万人产生不利影响的心肌疾病。第二次为 在这次研讨会之前，将为研究生举办为期两天的戈登研究研讨会（GRS） 和博士后研究员。此外，在GRC期间的每一次会议上，一名年轻的研究人员将与 一名高级研究员担任共同讨论领导人。创新的“海报快闪会议”和“这只是在” 发言人时段将用来突出最新新闻。这些创新的项目元素还将 最大限度地提高海报会议的知名度，并加强有前途的年轻人的融入和曝光 调查人员在现场进行了调查。我们预计，本次会议将吸引150-200基础和临床 所有职业阶段的科学家，性别，种族，遗产，研究学科，专业联系 （学术、工业、政府）和地理位置。我们的总体目标是促进：1）开放 对话和交流，2）有前途的年轻研究人员在 3）对ECC机制的基本理解以及该过程中的缺陷如何导致 受损的骨骼和心肌性能，和4）开发新的和有效的 治疗骨骼和心肌疾病。