权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Nutritional Therapy in Elderly with Heart Failure

老年心力衰竭的营养治疗

基本信息

批准号：
9332297
负责人：
ROBERT R WOLFE
金额：
$ 54.47万
依托单位：
ESSENTIAL BLENDS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-15 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9332297
关键词：
Activities of Daily Living Adverse effects Amino Acids Blood Glucose Blood flow Cardiac Clinical Comorbidity Consumption Data Development Drug usage EFRAC Effectiveness Elderly Emotional Exercise Exertion Failure Fasting Fatty Acids Feeling Formulation Gait speed Goals Hand Strength Health Heart failure Impairment Individual Insulin Leg Lipids Measures Metabolic Methodology Muscle Mitochondria Muscle Proteins Muscle Weakness Muscle function Nitric Oxide Nutritional Nutritional Support Oxides Patients Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Physical Function Placebos Production Protein Biosynthesis Quality of life Questionnaires Randomized Clinical Trials Resistance SF-36 Skeletal Muscle Surveys Symptoms Testing Tracer Translating Triglycerides Walking Weight Gain density design dietary supplements exercise capacity exercise training health related quality of life heart function improved metabolic abnormality assessment phase 1 study phase I trial physical conditioning response sarcopenia sedentary lifestyle social stable isotope

项目摘要

7. Project Summary/Abstract We have developed a nutritional formulation of amino acids called UpBeat that is designed to promote physical function and quality of life in older individuals with heart failure. Reduced exercise capacity is a prominent clinical feature of heart failure. This leads to progressive muscle weakness and a vicious cycle of sedentary behavior, weight gain, and subsequent development of metabolic abnormalities and sarcopenia. The impairment of physical function limits the health-related quality of life. Because of the limited capacity for exercise in most individuals with heart failure and the failure of drug therapy to completely resolve the symptoms, a wide variety of nutritional products have been marketed for therapy for heart failure. The data supporting the value of nutritional supplements for heart failure currently on the market either do not exist or are equivocal. UpBeat differs from most nutritional products for heart failure because it targets skeletal muscle function, and its value is supported by strong preliminary data. It is the goal of the current proposal to perform a randomized clinical trial (RCT) to test the ability of UpBeat to improve physical function and quality of life in older individuals with heart failure. The Specific Aims of this Phase II project are as follows: Specific Aim #1: We propose that 16 weeks of regular consumption of UpBeat will improve physical function in individuals with heart failure. Specific Aim #2: We propose that regular consumption of UpBeat will improve health-related quality of life. Specific Aim #3: We propose that regular consumption of UpBeat will lower the fasting concentrations of blood glucose and insulin, as well as triglycerides and low-density lipids. Positive results of this randomized clinical trial will provide evidence of the benefits of UpBeat for therapy of heart failure. In a more general sense, positive results will substantiate the benefits of targeting skeletal muscle function as a means to improve physical function and quality of life in heart failure.

7.项目总结/摘要我们开发了一种名为UpBeat的氨基酸营养配方，旨在促进老年心力衰竭患者的身体功能和生活质量。运动能力下降是一种心力衰竭的突出临床特征。这会导致进行性肌肉无力和恶性循环，久坐行为、体重增加以及随后的代谢异常和肌肉减少症的发展。的身体功能受损限制了与健康有关的生活质量。由于能力有限，运动在大多数患有心力衰竭和药物治疗失败的个体中完全解决了由于心力衰竭的症状，各种各样的营养产品已经上市用于治疗心力衰竭。数据支持目前市场上的心力衰竭营养补充剂的价值的证据要么不存在，模棱两可。UpBeat与大多数心力衰竭营养产品不同，因为它针对骨骼肌功能，其价值得到了强有力的初步数据的支持。本提案的目标是执行一项随机临床试验（RCT），以测试UpBeat改善身体功能和生活质量的能力，老年心力衰竭患者第二阶段项目的具体目标如下：具体目标#1：我们建议，16周的定期消费UpBeat将改善身体状况在心力衰竭患者中的作用。具体目标#2：我们建议定期食用UpBeat将改善与健康相关的质量，生活具体目标#3：我们建议定期食用UpBeat将降低空腹浓度血糖和胰岛素，以及甘油三酯和低密度脂蛋白。这项随机临床试验的积极结果将为UpBeat的益处提供证据，心力衰竭的治疗从更广泛的意义上说，积极的结果将证实目标确定的好处骨骼肌功能是改善心力衰竭患者身体功能和生活质量的一种手段。