Stable Isotope Analytical Core for Studies in Human Metabolism

用于人类代谢研究的稳定同位素分析核心

• 批准号: 7943931
• 负责人: ROBERT R WOLFE
• 金额: $ 56.19万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7943931
• 关键词: Acute; Collaborations; Communities; Data Analyses; Development; Fee-for-Service Plans; Financial Support; Funding; Future; Goals; Human; Marketing; Metabolic; Metabolic Pathway; Metabolism; Methodology; Methods; Nutritional Support; Outcome; Research; Research Personnel; Research Project Grants; Research Technics; Resources; Sampling; Services; Tracer; Training; abstracting; base; human subject; in vivo; investigator training; metabolic abnormality assessment; method development; response; stable isotope; tool

DESCRIPTION (provided by applicant): Stable isotope tracer methodology enables in vivo quantification of acute responses of metabolic pathways. In many previous studies we have shown that the results of metabolic studies with stable isotopes have accurately predicted long-term outcomes of nutritional therapies. A primary goal of this core will be to support metabolic research utilizing stable isotope methodology throughout the scientific community. Support of stable isotope tracer studies will include sample and data analysis, and training. We will also continue to develop new methodologies as needed to support these studies. In addition, we will actively train investigators on stable isotope tracer methodology. Finally, we will seek to extend collaborations throughout the world to develop a market for our analytical services and to provide for continued financial support. The core will prioritize stable isotope analyses for NIH-funded projects; however, any investigator utilizing stable isotope methodology may request analytical services. The PI is an experienced and well respected researcher in stable isotope methodology who moved from the UTMB and Shriners to University Arkansas and is receiving excellent support from the university. The aims of this project are to provide analytical support for research grants utilizing stable isotope methodology; to develop new methods to support studies of metabolic processes; to educate the scientific community regarding the in vivo applications of tracer methodology using stable isotopes in human subjects; and enhance collaborations to develop a clientele for continued financial support. Project Narrative: This proposal describes a stable isotope analytical core to support world-wide research in human metabolic studies. The core offers routine and specialized sample analysis on a minimal fee-for-service basis. In addition, it will provide assistance in methods development and training in the use of stable isotopes in human metabolic studies.

描述（由申请方提供）：稳定同位素示踪方法能够在体内定量代谢途径的急性反应。在许多以前的研究中，我们已经表明，稳定同位素代谢研究的结果准确地预测了营养治疗的长期结果。该核心的主要目标是支持整个科学界利用稳定同位素方法进行代谢研究。对稳定同位素示踪剂研究的支持将包括样本和数据分析以及培训。我们还将继续根据需要开发新的方法来支持这些研究。此外，我们将积极培训研究人员掌握稳定同位素示踪方法。最后，我们将寻求在世界各地扩大合作，为我们的分析服务开发市场，并提供持续的财政支持。核心将优先考虑NIH资助项目的稳定同位素分析;然而，任何使用稳定同位素方法的研究人员都可以要求分析服务。PI是一位经验丰富、备受尊敬的稳定同位素方法学研究人员，他从UTMB和Shriners搬到了阿肯色州大学，并得到了大学的大力支持。该项目的目的是为利用稳定同位素方法的研究赠款提供分析支助;开发新的方法以支助代谢过程的研究;教育科学界关于在人体中使用稳定同位素的示踪方法的体内应用;以及加强合作以发展可获得持续财政支助的客户。 项目叙述：该提案描述了一个稳定同位素分析核心，以支持全球范围内的人类代谢研究。该核心提供常规和专业的样品分析在最低的收费服务的基础上。此外，它还将在人类代谢研究中使用稳定同位素的方法开发和培训方面提供援助。