Is low dose amitriptyline more effective than placebo in the management of chronic, neuropathic low back pain? A double-blind, randomized, placebo-controlled trial with an economic evaluation

在治疗慢性神经性腰痛方面，低剂量阿米替林是否比安慰剂更有效？

• 批准号: nhmrc : 1024401
• 负责人: A/Pr Anita Wluka
• 金额: $ 20.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/low-dose-amitriptyline-economic-evaluation/110345
• 关键词: low; dose; amitriptyline; more; effective

Chronic low back pain is a major public health problem in Australia. Antidepressants are a common treatment for low back pain, with physicians often prescribing them at low doses for the treatment of pain. However, the use of antidepressants for low back pain is unproven. We aim to perform a clinical trial to examine whether antidepressants are more effective than placebo in reducing pain and disability in patients with chronic low back pain.

慢性腰痛是澳大利亚的一个主要公共卫生问题。抗抑郁药是腰痛的常见治疗方法，医生经常以低剂量开处方治疗疼痛。然而，使用抗抑郁药治疗腰痛尚未得到证实。我们的目标是进行一项临床试验，以检查抗抑郁药是否比安慰剂更有效地减轻慢性腰痛患者的疼痛和残疾。