Targeting bone marrow lesions to find interventions in the progression of osteoarthritis

针对骨髓病变寻找骨关节炎进展的干预措施

• 批准号: nhmrc : 1042482
• 负责人: A/Pr Anita Wluka
• 金额: $ 31.17万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-bone-marrow-progression-osteoarthritis/111474
• 关键词: Targeting; bone; marrow; lesions; find

It is essential to elucidate the underlying cause(s) of osteoarthritis because our current level of understanding of this condition has failed to produce effective treatments. Lesions in the bone under the cartilage (BMLs), seen using MRI, have strong potential value for the objective monitoring and management of OA. However, because the nature of BMLs is not well understood, the aim of this application is to perform a comprehensive study of BMLs in OA bone.

阐明骨关节炎的根本原因至关重要，因为我们目前对这种疾病的理解水平未能产生有效的治疗方法。使用MRI观察到的软骨下骨（BML）病变对OA的客观监测和管理具有很强的潜在价值。然而，由于BML的性质尚未得到很好的理解，本申请的目的是对OA骨中的BML进行全面研究。