Cell Surface Recognition and Cell Interactions
细胞表面识别和细胞相互作用
基本信息
- 批准号:9205236
- 负责人:
- 金额:$ 34.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1978
- 资助国家:美国
- 起止时间:1978-07-01 至 2019-01-31
- 项目状态:已结题
- 来源:
- 关键词:Adenylate CyclaseAdhesionsAgglutininsAlgaeAnimalsApicalBindingBiochemicalBiochemical MarkersBiological ModelsBiologyCell CommunicationCell fusionCell membraneCell surfaceCellsChlamydomonasCiliaCuesCyclic NucleotidesCytoplasmDevelopmentDiffusionDiseaseEmployee StrikesErinaceidaeEukaryotaExclusionFertilizationFundingGenesGerm CellsGreen AlgaeGrowthHomeostasisInterphase CellKinesinLengthLigandsLinkMalignant NeoplasmsMembraneMembrane ProteinsMicrotubulesModelingMolecularMotorMovementNuclear FamilyOrganellesPathway interactionsPost-Translational Protein ProcessingPropertyProteinsRegulationRestRoleSHH geneSensorySignal PathwaySignal TransductionSignaling ProteinSystemTestingTimeTissuesVertebratesVesicleadhesion receptorbaseciliopathycilium biogenesisdepolymerizationfusion genehuman diseasemembermutantnovelpreventprotein transportpublic health relevancereceptorresponsetooltraffickingtranscription factortranscriptometranscriptome sequencing
项目摘要
DESCRIPTION (provided by applicant): Key signaling pathways in development depend on the dynamic cellular compartment created by the primary cilium. In vertebrates, the Shh pathway is activated only when the plasma membrane-localized Shh effector Smo accumulates in the primary cilium, where Smo regulates cilium-localized transcription factors and tissue development. In the unicellular biflagellated green alga Chlamydomonas, the adhesion receptor SAG1 is present on the plasma membrane and restricted from entering the cilium by a functional barrier. Upon cilium-generated signaling during cell-cell interactions, however, SAG1 moves to the bases of the cilia, overcomes the barrier, and moves onto the ciliary membrane. A crucial unanswered question in biology is how cells establish and regulate the protein composition of cilia during activation of signaling pathways. Unlike in animal cells, we can isolate cilia from Chlamydomonas and we can inactivate the ciliary transport machinery, IFT. Here, we will exploit the multiple advantages of this simple system to study the cellular and molecular mechanisms that underlie the ability of cells to regulate the ciliary localization of a membrane protein during cilium-generated signaling.
描述(由申请人提供):发育中的关键信号通路取决于初级纤毛产生的动态细胞区室。在脊椎动物中,只有当质膜定位的Shh效应Smo在初级纤毛中积累时,Shh通路才被激活,Smo在初级纤毛中调节纤毛定位的转录因子和组织发育。在单细胞双鞭毛绿色衣原体中,粘附受体SAG 1存在于质膜上,并通过功能屏障限制其进入纤毛。然而,在细胞-细胞相互作用期间纤毛产生信号后,SAG 1移动到纤毛的基部,克服屏障,并移动到睫状膜上。生物学中一个关键的未回答的问题是细胞如何在信号通路的激活过程中建立和调节纤毛的蛋白质组成。与动物细胞不同,我们可以从衣原体中分离出纤毛,我们可以分离出纤毛运输机制,IFT。在这里,我们将利用这个简单的系统来研究细胞和分子机制的基础上的能力,细胞调节纤毛定位的膜蛋白在纤毛产生的信号。
项目成果
期刊论文数量(44)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Flagellar adhesion and deadhesion in Chlamydomonas gametes: effects of tunicamycin and observations on flagellar tip morphology.
衣藻配子中的鞭毛粘附和死粘附:衣霉素的影响和对鞭毛尖端形态的观察。
- DOI:10.1002/jsscb.1981.380160407
- 发表时间:1981
- 期刊:
- 影响因子:0
- 作者:Snell,WK
- 通讯作者:Snell,WK
The ciliary membrane.
- DOI:10.1016/j.ceb.2010.03.010
- 发表时间:2010-08
- 期刊:
- 影响因子:7.5
- 作者:Rohatgi, Rajat;Snell, William J.
- 通讯作者:Snell, William J.
Molecular cloning of a protein kinase whose phosphorylation is regulated by genetic adhesion during Chlamydomonas fertilization.
一种蛋白激酶的分子克隆,其磷酸化在衣藻受精过程中受到遗传粘附的调节。
- DOI:10.1073/pnas.93.1.39
- 发表时间:1996
- 期刊:
- 影响因子:11.1
- 作者:Kurvari,V;Zhang,Y;Luo,Y;Snell,WJ
- 通讯作者:Snell,WJ
Development of capping ability during differentiation of HL-60 human promyelocytic leukemia cells.
HL-60 人早幼粒细胞白血病细胞分化过程中加帽能力的发展。
- DOI:10.1002/jcp.1041060114
- 发表时间:1981
- 期刊:
- 影响因子:5.6
- 作者:Brown,WJ;Norwood,CF;Smith,RG;Snell,WJ
- 通讯作者:Snell,WJ
Lidocaine reversibly inhibits fertilization in Chlamydomonas: a possible role for calcium in sexual signalling.
利多卡因可逆地抑制衣藻的受精:钙在性信号中的可能作用。
- DOI:10.1083/jcb.94.3.607
- 发表时间:1982
- 期刊:
- 影响因子:0
- 作者:Snell,WJ;Buchanan,M;Clausell,A
- 通讯作者:Clausell,A
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William J Snell其他文献
William J Snell的其他文献
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{{ truncateString('William J Snell', 18)}}的其他基金
Conserved mechanisms of ciliary signaling and cell-cell fusion
纤毛信号传导和细胞间融合的保守机制
- 批准号:
10522540 - 财政年份:2022
- 资助金额:
$ 34.2万 - 项目类别:
Conserved mechanisms of ciliary signaling and cell-cell fusion
纤毛信号传导和细胞间融合的保守机制
- 批准号:
10797497 - 财政年份:2022
- 资助金额:
$ 34.2万 - 项目类别:
Conserved mechanisms of ciliary signaling and cell-cell fusion
纤毛信号传导和细胞间融合的保守机制
- 批准号:
10707152 - 财政年份:2022
- 资助金额:
$ 34.2万 - 项目类别:
Membrane protein localization and function during ciliary signaling and cell-cell fusion
纤毛信号传导和细胞-细胞融合过程中膜蛋白的定位和功能
- 批准号:
9277022 - 财政年份:2017
- 资助金额:
$ 34.2万 - 项目类别:
Membrane protein localization and function during ciliary signaling and cell-cell fusion
纤毛信号传导和细胞-细胞融合过程中膜蛋白的定位和功能
- 批准号:
10152601 - 财政年份:2017
- 资助金额:
$ 34.2万 - 项目类别:
GAMETE MEMBRANE ADHESINO AND FUSION DURING FERTILIZATION
受精过程中配子膜的粘附和融合
- 批准号:
7919159 - 财政年份:2009
- 资助金额:
$ 34.2万 - 项目类别:
Structural studies on dynein-microtubule complex
动力蛋白-微管复合物的结构研究
- 批准号:
7163426 - 财政年份:2006
- 资助金额:
$ 34.2万 - 项目类别:
Gamete membrane adhesion and fusion during fertilization
受精过程中配子膜的粘附和融合
- 批准号:
6752066 - 财政年份:1998
- 资助金额:
$ 34.2万 - 项目类别:
Gamete Membrane Adhesion and Fusion During Fertilization
受精过程中配子膜的粘附和融合
- 批准号:
8538993 - 财政年份:1998
- 资助金额:
$ 34.2万 - 项目类别:
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