Mechanistic Studies on video guided acupuncture imagery treatment of pain

视频引导针灸意象治疗疼痛的机理研究

• 批准号: 9206721
• 负责人: JIAN KONG
• 金额: $ 42.58万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9206721
• 关键词: Absence of pain sensation; Acupuncture Points; Acupuncture Therapy; Affect; Affective; Aftercare; Analgesics; Anterior; Behavioral; Biological Neural Networks; Brain; Brain imaging; Brain region; Caring; Clinical; Clinical Treatment; Complement; Crossover Design; Degenerative polyarthritis; Development; Devices; Disabled Persons; Disease; Dorsal; Elderly; Electroacupuncture; Empathy; Event; Feeling; Foundations; Functional Magnetic Resonance Imaging; Gossypium; Healed; Health; Home environment; Human; Image; Imagery; Imagination; Individual; Insula of Reil; Investigation; Knee Osteoarthritis; Literature; Manuals; Medical; Meta-Analysis; Methods; Mind-Body Intervention; Mining; Modality; Nature; Needles; Neurocognitive; New York; Outcome; Pain; Pain Threshold; Pain intensity; Pain management; Participant; Patients; Pattern; Perception; Phase; Pilot Projects; Placebos; Process; Psyche structure; Publishing; Randomized; Recruitment Activity; Regulation; Research; Rest; Role; Science; Self-Administered; Sensory; Signal Transduction; Social Psychology; Somatosensory Cortex; Stimulus; Support System; Swab; System; Testing; Therapeutic; Therapeutic Effect; Touch sensation; Uncertainty; Visual; abstracting; base; brain pathway; chronic pain; cingulate cortex; comparative; experience; functional improvement; healing; improved; knee pain; mental imagery; midbrain central gray substance; mind body interaction; neuroimaging; neuromechanism; novel; operation; patient population; relating to nervous system; response; systematic review; treatment group; trend

Project Summary / Abstract The use of imagery to treat illness is one of the oldest medical practices. Nevertheless, the mechanism of the treatment remains unknown. Recent brain imaging studies suggest that underlying the functional nature of mental imagery may be the overlapping neurocognitive operations that support imagination, perception, and action. Acupuncture is an ancient invasive therapeutic method. Previous studies have shown that both the experience of acupuncture needle stimulation and the visualization of acupuncture needle stimulation can provoke overlapping brain activation, which suggests that visualizing or imagining acupuncture may achieve therapeutic effects through a brain pathway similar to actual acupuncture treatment. This application will investigate the underlying brain mechanisms of video-guided acupuncture imagery treatment (VGAIT), a novel mind-body treatment modality. In this treatment, subjects will watch a video of acupuncture previously administered on their own bodies and imagine this prior treatment being concurrently applied. In the R61 phase, using a crossover design and functional magnetic resonance imaging (fMRI), we will investigate the cortical fMRI signal changes and resting state functional connectivity changes evoked by 1) VGAIT, 2) VGAIT control condition (subjects will watch a video of a cotton swab touching specific points on their bodies and imagine it being concurrently applied), 3) verum acupuncture, and 4) sham acupuncture administered on healthy subjects. In the R33 phase, knee osteoarthritis (OA) patients will be recruited and randomized to one of four treatment groups for one month: 1) VGAIT, 2) a VGAIT control condition, 3) verum acupuncture, and 4) sham acupuncture. We will investigate the fMRI signal changes and resting state functional connectivity changes evoked by the different conditions. This project will facilitate the development of new mind-body intervention methods that can directly benefit patients suffering from chronic pain. It would be especially beneficial to elderly and disabled patients who have limited access to acupuncture and medical care and could benefit from self- administered, at-home treatment following acupuncture treatment sessions. Most importantly, a comparative investigation of imagery acupuncture, real acupuncture, and sham acupuncture will deepen our understanding of mind-body interaction, imagery treatment, acupuncture, and pain management.

项目摘要/摘要 使用图像来治疗疾病是最古老的医学实践之一。尽管如此， 治疗机制尚不清楚。最近的脑成像研究表明，潜在的 心理意象的功能本质可能是重叠的神经认知操作， 支持想象力、知觉和行动。针灸是一种古老的侵入性治疗方法。 以往的研究表明，针灸刺激的体验和 针刺刺激的可视化可以刺激重叠的大脑激活，这 提示可视化或想象针灸可能通过大脑达到治疗效果 与实际针灸治疗相似的路径。 这项应用将研究视频引导针灸的潜在大脑机制 表象治疗(VGAIT)，一种新的心身治疗方式。在这种治疗中，受试者将 观看之前在自己身上进行针灸的视频，想象一下 正在同时应用的治疗。在R61阶段，使用交叉设计和功能 磁共振成像(FMRI)，我们将研究大脑皮质fMRI信号的变化和休息 1)VGAIT、2)VGAIT控制条件引起的状态功能连通性变化(受试者将 观看一段棉签触摸他们身上特定部位的视频，想象一下 同时应用)，3)真针，和4)假针刺对健康人 研究对象。在R33阶段，膝关节骨关节炎(OA)患者将被招募并随机分为一组 四组治疗1个月：1)VGAIT，2)VGAIT控制条件，3)Verum 针灸和假针灸。我们将研究fMRI信号的变化和静息状态 不同条件引起的功能连通性变化。 该项目将促进新的身心干预方法的开发，这种方法可以直接 有利于患有慢性疼痛的患者。这对老年人和残疾人尤其有益。 患者获得针灸和医疗护理的机会有限，并可能受益于自我 针灸治疗后，在家中进行治疗。最重要的是，一个 表象针刺、真针刺、假针刺意志的比较研究 加深我们对身心互动、意象治疗、针灸和疼痛的理解 管理层。