Modulation effects of Baduanjin mind-body exercise on subjective cognitive decline

总结 主观认知下降（SCD），自我报告的记忆或认知问题的感知，正在接受 越来越多的关注作为阿尔茨海默病（AD）发展的风险因素。由于SCD显示 在临床损伤发生之前，这可能是进行干预的最佳阶段/时间窗 在进行性神经功能丧失之前对AD和年龄相关性痴呆进行预防性治疗， 不可逆转的认知障碍 最近，身心干预已经证明了它们在预防认知能力下降方面的潜力。 然而，这些身心疗法包括一系列复杂的实践，每一种都有不同的 特点和重点。因此，它们可能与不同的机制和治疗效果有关。 八段锦（BDJ）是一种创新而简单的身心运动，由八个简单的动作组成， 可以在家里通过视频指导轻松练习，从而使其成为老年人更合适的选择 与其他更复杂的运动相比，认知能力下降。在以前的研究中，我们发现BDJ显著 改善记忆和执行功能，海马体的静息状态功能连接， 背外侧前额叶皮质，内侧颞区和壳核的灰质体积， 成年人了此外，我们发现BDJ可以产生更大的认知功能改善， 通过Wechsler记忆量表（WMS）子评分和更广泛的灰质脑体积测量 内侧颞叶和壳核改变。最近的一项试点研究表明，与步行相比， 6个月的BDJ治疗和健康教育显著改善MCI患者的认知功能。这些 研究结果为当前的应用提供了坚实的基础。 该提案旨在研究1）纵向BDJ对认知下降的预防作用，2） BDJ对海马和双侧背外侧区静息态功能连接的调制作用 前额叶皮层，以及3）BDJ对SCD患者脑形态计量学的调制作用， 与对照相比。我们相信，这项研究将1）显着改善MCI和AD的预防， 直接受益于患有这些高度流行的疾病的患者，2）提高我们对 神经生物学，通过它身心干预影响认知和健康，3）推进我们的 了解SCD，AD和年龄相关性痴呆的病理生理学和发展。

Summary Subjective cognitive decline (SCD), the self-reported perception of memory or cognitive problems, is receiving increasing attention as a risk factor for the development of Alzheimer’s disease (AD). Since SCD manifests before the onset of clinical impairment, it might be the optimal stage/window of time at which to intervene with preventative therapies for AD and age-related dementia before the progressive neurological loss and irreversible cognitive impairment. Recently, mind-body interventions have demonstrated their potential in preventing cognitive decline. Nevertheless, these mind-body therapies encompass a family of complex practices, each with different characteristics and focus. Therefore, they may be associated with different mechanisms and treatment effects. Baduanjin (BDJ) is an innovative and simple mind-body exercise consisting of eight simple movements that can be easily practiced at home with video guidance, thereby making it a more suitable option for older adults with cognitive decline than other more complex exercises. In a previous study, we found that BDJ significantly improved memory and executive function, resting state functional connectivity of the hippocampus and dorsolateral prefrontal cortex, and grey matter volume of the medial temporal area and putamen in older adults. In addition, we found that BDJ could produce significantly greater cognitive function improvement, as measured by the Wechsler Memory Scale (WMS) sub-score, and more extensive grey matter brain volume changes at medial temperal lobe and putamen. A more recent pilot study showed that, compared to walking and health education, six months of BDJ significantly improved cognitive function in patients with MCI. These findings provide a solid foundation for the current application. This proposal aims to investigate 1) the preventative effect of longitudinal BDJ on cognitive decline, 2) the modulation effect of BDJ on resting state functional connectivity of the hippocampus and bilateral dorsolateral prefrontal cortex, and 3) the modulation effect of BDJ on brain morphometry in individuals with SCD as compared to controls. We believe that this study will 1) significantly improve the prevention of MCI and AD and directly benefit patients suffering from these highly prevalent disorders, 2) enhance our understanding of the neurobiology through which mind-body interventions affect cognition and health, and 3) advance our understanding of the pathophysiology and development of SCD, AD, and age-related dementia.