Modulation effects of Baduanjin mind-body exercise on subjective cognitive decline

八段锦身心锻炼对主观认知下降的调节作用

• 批准号: 10017137
• 负责人: JIAN KONG
• 金额: $ 80.61万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017137
• 关键词: Affect; Age-associated memory impairment; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease therapy; Area; Attention; Bilateral; Biological Markers; Blood Glucose; Blood Tests; Body mass index; Brain; Brain-Derived Neurotrophic Factor; Breathing; Characteristics; Clinical; Clinical assessments; Cognition; Cognitive; Complex; Dementia; Development; Disease; Elderly; Exercise; Family; Foundations; Functional disorder; Health; Health education; High Density Lipoproteins; Hippocampus (Brain); Home environment; Impaired cognition; Impairment; Individual; Insula of Reil; Interleukin-6; Intervention; Lobe; Low Prevalence; Low-Density Lipoproteins; Magnetic Resonance Imaging; Measurement; Measures; Medial; Memory; Memory Loss; Methods; Mind-Body Intervention; Movement; Neurobiology; Neurologic; Patient Self-Report; Patients; Perception; Performance; Pharmacologic Substance; Phase; Pilot Projects; Prefrontal Cortex; Prevention; Preventive therapy; Quality of life; Randomized; Reporting; Research; Rest; Risk Factors; Solid; Tai Ji; Tendon structure; Time; Triglycerides; Walking; active control; age related; attentional control; blood pressure reduction; body-mind; brain volume; cognitive function; cognitive testing; cooperative study; cost; cytokine; epidemiological model; executive function; exercise program; flexibility; follow-up; functional improvement; gray matter; improved; innovation; insight; mild cognitive impairment; morphometry; novel; physical conditioning; preclinical study; prevent; putamen; strength training; treatment effect

Summary Subjective cognitive decline (SCD), the self-reported perception of memory or cognitive problems, is receiving increasing attention as a risk factor for the development of Alzheimer’s disease (AD). Since SCD manifests before the onset of clinical impairment, it might be the optimal stage/window of time at which to intervene with preventative therapies for AD and age-related dementia before the progressive neurological loss and irreversible cognitive impairment. Recently, mind-body interventions have demonstrated their potential in preventing cognitive decline. Nevertheless, these mind-body therapies encompass a family of complex practices, each with different characteristics and focus. Therefore, they may be associated with different mechanisms and treatment effects. Baduanjin (BDJ) is an innovative and simple mind-body exercise consisting of eight simple movements that can be easily practiced at home with video guidance, thereby making it a more suitable option for older adults with cognitive decline than other more complex exercises. In a previous study, we found that BDJ significantly improved memory and executive function, resting state functional connectivity of the hippocampus and dorsolateral prefrontal cortex, and grey matter volume of the medial temporal area and putamen in older adults. In addition, we found that BDJ could produce significantly greater cognitive function improvement, as measured by the Wechsler Memory Scale (WMS) sub-score, and more extensive grey matter brain volume changes at medial temperal lobe and putamen. A more recent pilot study showed that, compared to walking and health education, six months of BDJ significantly improved cognitive function in patients with MCI. These findings provide a solid foundation for the current application. This proposal aims to investigate 1) the preventative effect of longitudinal BDJ on cognitive decline, 2) the modulation effect of BDJ on resting state functional connectivity of the hippocampus and bilateral dorsolateral prefrontal cortex, and 3) the modulation effect of BDJ on brain morphometry in individuals with SCD as compared to controls. We believe that this study will 1) significantly improve the prevention of MCI and AD and directly benefit patients suffering from these highly prevalent disorders, 2) enhance our understanding of the neurobiology through which mind-body interventions affect cognition and health, and 3) advance our understanding of the pathophysiology and development of SCD, AD, and age-related dementia.

概括 主观认知下降（SCD）是对记忆或认知问题的自我报告的感知，正在接受 作为发展阿尔茨海默氏病（AD）发展的危险因素的关注越来越多。由于SCD表现出来 在临床障碍开始之前，可能是干预的最佳时间/时间窗口 进行性神经系统丧失之前的AD和与年龄相关的痴呆的预防性疗法 不可逆转的认知障碍。 最近，身心干预表明了它们在预防认知能力下降方面的潜力。 然而，这些心身疗法包括一个复杂的实践家庭，每个家庭都有不同 特征和重点。因此，它们可能与不同的机制和治疗效果有关。 Baduanjin（BDJ）是一种创新而简单的思维体练习，由八个简单的动作组成 可以通过视频指导轻松地在家中实行，从而使其成为老年人更合适的选择 与其他更复杂的练习相比，认知能力下降。在先前的研究中，我们发现BDJ显着 改进的记忆力和执行功能，静止的海马和 背侧前额叶皮层和媒体临时区域的灰质体积和较老 成年人。此外，我们发现BDJ可以产生更大的认知功能改善，因为 通过Wechsler记忆量表（WMS）子得分和更广泛的灰质大脑体积来衡量 内侧温度叶和壳虫的变化。最近的一项试点研究表明，与步行相比 和健康教育，六个月的BDJ显着改善了MCI患者的认知功能。这些 调查结果为当前申请提供了坚实的基础。 该建议旨在调查1）纵向BDJ对认知能力下降的预防作用，2） BDJ对海马和双侧双侧静止状态功能连通性的调节作用 前额叶皮层和3）BDJ对SCD个体的脑形态计量学的调节作用AS 与对照组相比。我们认为这项研究将1）显着改善MCI和AD的预防 直接使患有这些高度普遍疾病的患者受益，2）增强我们对 心身干预措施会影响认知和健康的神经生物学，3） 了解SCD，AD和与年龄有关的痴呆的病理生理学和发展。