Developing of a computer-based multimodal mind and body approach for mild cognitive decline

总结 轻度认知功能障碍（MCI）是介于正常衰老和诊断为轻度认知功能障碍之间的一种中间状态。 临床上可能的极早期阿尔茨海默病（AD）。由于MCI在AD发病前出现， 最佳阶段，其中干预预防性治疗AD和年龄相关性痴呆之前， 进行性神经功能丧失和不可逆的认知障碍。然而，药物治疗 MCI远远不能令人满意，这突出表明迫切需要新的MCI治疗方案。 八段锦（BDJ）是一种独特而创新的身心运动，其特点是对称的相互作用， 身体姿势和动作，重点是加强肌肉和肌腱。它由八个简单的 通过视频/音频指导，可以在家中轻松练习的动作。这些特点使其 适合患有MCI的老年人。我们小组和其他人的研究表明， 改善MCI老年人认知功能的潜力。然而，研究也表明， 对BDJ的反应差异很大，有些人只表现出中度反应。克服 挑战，这个应用程序的目的是整合BDJ与其他心灵和身体的方法，以开发一个更 MCI的有效治疗选择。 第一阶段R41（STTR）应用的目标是开发一种基于计算机的多模态身心 方法（cbMMBA）来改善轻度认知障碍的认知功能。具体来说，我们将首先开发一个功能 cbMMBA平台（原型）集成BDJ，指压和放松技术（目标1）。我们选择 这些方法，不仅是因为其中一些方法本身已经证明了它们的潜力， MCI /痴呆症的认知功能，但因为它们也可以相互积极地产生 协同效应接下来，我们将在MCI上使用cbMMBA进行可行性研究（目标2）。 这项应用如果成功，将为MCI提供一种具有成本效益且易于获得的治疗选择， 其他年龄相关性痴呆，显著改善MCI发展的预防，并直接受益 患有高度流行的疾病的患者，特别是对于那些可能获得有限信息的患者， 人的思想和身体干预。

Summary Mild cognitive impairment (MCI) represents an intermediate state between normal aging and the diagnosis of clinically probable very early Alzheimer's disease (AD). Since MCI manifests before the onset of AD, it may be the optimal stage in which to intervene with preventative therapies for AD and age-related dementia before progressive neurological loss and irreversible cognitive impairment. Nevertheless, pharmacologic treatment for MCI is far from satisfactory, highlighting the urgent need for new treatment solutions for MCI. Baduanjin (BDJ) is a unique and innovative mind-body exercise characterized by the interplay of symmetrical physical postures and movements, focusing on strengthening muscles and tendons. It consists of eight simple movements that can be easily practiced at home when guided by videos /audio. These characteristics make it a suitable option for older adults with MCI. Studies from both our group and others have demonstrated its potentials for improving cognitive function for older adults with MCI. Nevertheless, studies also showed that the response to BDJ varies significantly, some individuals demonstrate only a moderate response. To overcome the challenge, this application aims to integrate BDJ with other mind and body approaches to develop a more effective treatment option for MCI. The goal of this Phase I R41 (STTR) application is to develop a computer-based multimodal mind and body approach (cbMMBA) to improve the cognitive function for MCI. Specifically, we will first develop a functional cbMMBA platform (prototype) integrating BDJ, acupressure, and relaxation techniques (Aim 1). We chose these methods, not only because some of these methods alone have demonstrated their potential to improve cognitive function in MCI / dementia, but because they also can interact with each other positively to produce synergistic effects. Next, we will perform a feasibility study using the cbMMBA on MCI (Aim 2). This application, if successful, will provide a cost-effective and easily accessible treatment option for MCI and other age-related dementia, significantly improve the prevention of MCI development, and directly benefit patients suffering from the highly prevalent disorder, particularly for those who may have limited access to in- person mind and body interventions.