T Cell Costimulatory Pathways: Function and Interactions

T 细胞共刺激途径：功能和相互作用

• 批准号: 9121451
• 负责人: Arlene H. Sharpe
• 金额: $ 3.96万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9121451
• 关键词: Administrator; Advisory Committees; Agreement; Animals; Antibodies; Autoimmunity; Biological Sciences; Boston; CD8B1 gene; Chronic; Clinical Trials; Collaborations; Collection; Combined Modality Therapy; Communication; Communities; Contracts; Dana-Farber Cancer Institute; Development; Disease model; Funding; Future; General Hospitals; Goals; Graft Rejection; Grant; Group Meetings; Hospitals; Immune Tolerance; Immunity; Individual; Infection; Institution; Interleukin-2; Knockout Mice; Leadership; Manuscripts; Massachusetts; Measures; Mediator of activation protein; Minnesota; Monitor; Monoclonal Antibodies; Mouse Strains; Mutant Strains Mice; Online Systems; Participant; Pathway interactions; Play; Preparation; Principal Investigator; Program Research Project Grants; Progress Reports; PubMed; Publications; Reagent; Research Activity; Research Personnel; Resource Sharing; Resources; Role; Secure; Services; Structure; T cell response; T-Cell Activation; T-Lymphocyte; Telephone; The Jackson Laboratory; Therapeutic; Time; Transgenic Mice; Translating; Translations; Transplantation; Universities; Virus Diseases; Woman; antimicrobial; biological systems; cancer immunotherapy; clinically relevant; conflict resolution; data portal; data sharing; effective therapy; exhaust; exhaustion; human disease; in vivo; insight; interest; medical schools; meetings; novel; novel therapeutic intervention; operation; organizational structure; programs; research study; symposium; tool

The Administrative Core will be responsible for providing scientific administration and coordination, fiscal oversight and administrative support for this Program Project Grant, to enable this PPG to continue to be a highly interactive and integrated program. The Administrative Core will coordinate PPG scientific group meetings among investigators at Harvard Medical School, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, Emory University and the University of Minnesota using video conferencing and telephone conference calls. The Administrative Core will provide effective communication services to enable PPG investigators to share data, plan experiments, and enhance their collaborations. In addition, the Administrative Core will arrange an annual PPG meeting for investigators in Boston. Administratively, this Core will coordinate annual progress reports and renewal of sub-contract agreements, and will liaise between the grants offices of the various institutions and the Harvard Medical School Sponsored Programs Administration office. Dr. Arlene Sharpe, as Program Project Principal investigator and her institution Harvard Medical School, will be responsible for this application and for the collaborative research activities described. Dr. Arlene Sharpe will direct this Core with the support of her administrative assistant Sarah Hillman and grants administrator Sandra Hatten. Core A has the following Specific Aims. Aim 1: To provide administrate support for the PPG by facilitating optimal interactions among all participants in the PPG; coordinating the three PPG projects with the two scientific cores; maintaining fair, effective communication and cooperation among program investigators; Managing program activities and contractual agreements; Overseeing allocation of funds; and providing a measure of oversight for PPG through the Scientific Advisory Board, and Aim 2: To maintain a web-based secure portal for data sharing to facilitate sharing of data in real time, planning of future experiments and collaboration.

行政核心将负责提供科学管理和协调，财政 对该计划项目赠款的监督和行政支持，使该PPG能够继续成为 高度互动和集成的程序。行政核心将协调PPG科学小组 达纳·法伯（Dana-Farber）哈佛医学院的调查员和妇女医院的调查人员会议 癌症研究所，马萨诸塞州综合医院，埃默里大学和明尼苏达大学使用 视频会议和电话电话会议。行政核心将有效 通信服务使PPG调查人员能够共享数据，计划实验并增强其 协作。此外，行政核心将安排每年为调查人员举行的PPG会议 波士顿。在行政上，该核心将协调年度进度报告和分包合同的续订 协议，并将在各个机构的赠款办公室和哈佛医疗机构之间联络 学校赞助计划管理办公室。 Arlene Sharpe博士，作为计划项目负责人 调查员及其机构哈佛医学院将负责此申请和 所描述的协作研究活动。阿琳·夏普（Arlene Sharpe）博士将在她的支持下指导这一核心 行政助理莎拉·希尔曼（Sarah Hillman）和授予行政长官桑德拉·哈滕（Sandra Hatten）。 核心A具有以下特定目标。目标1：通过促进为PPG提供管理支持 PPG中所有参与者之间的最佳相互作用；与两个项目协调三个PPG项目 科学核心；保持计划调查人员之间的公平，有效的沟通和合作； 管理计划活动和合同协议；监督资金分配；并提供一个 通过科学顾问委员会对PPG的监督度量，目标2：维护基于网络的 安全门户网站用于数据共享，以实时促进数据共享，计划未来的实验和 合作。