AIDS Malignancies Training and Research International Program (AMTRIP)

 描述(由申请人提供)：内布拉斯加-林肯大学与赞比亚合作伙伴合作，自2000年以来一直在管理NIH Fogarty国际中心培训计划，以发展赞比亚的基础设施和研究能力，以推进艾滋病毒和艾滋病相关疾病的预防、诊断和管理。虽然该计划在推进这些目标方面取得了巨大成功，但它将于今年结束，合作机构正在提议实施一项新的、更有针对性的培训计划，以解决该地区的一个关键健康问题：艾滋病相关癌症。随着癌症疾病医院(CDH)这一新合作伙伴的加入，该项目的目标是培训赞比亚生物医学研究人员和从业人员的干部，掌握必要的技能，以推进该国的癌症生物学研究议程，并为该国为癌症诊断和治疗的癌症基因组学新时代做好准备。CDH位于UNZA和UTH校区，是赞比亚唯一的主要癌症治疗中心，将作为拟议方案的主要国内低收入和中等收入国家机构。自2006年成立以来，CDH在发展其治疗和进行癌症研究的能力方面取得了重大进展，但仍然需要更多和训练有素的癌症研究人员和肿瘤学家。为了在赞比亚培训和留住这类人员，方案设计围绕以下具体目标组织，每个目标侧重于不同类型的培训：1)为四名赞比亚研究员提供密集的学术指导和研究经验，以获得相关癌症研究领域的硕士、公共卫生硕士或医学硕士学位(每名研究员两年的培训)；2)为两名赞比亚研究员提供密集的学术指导和研究经验，从而获得相关癌症研究领域的博士学位(每名研究员五年的培训)；3)为5名研究生提供与分子病理学、癌症生物学和基因组学相关主题的中期(6个月)技术培训机会；以及4)举办讲习班，旨在加强赞比亚的基础、临床、实施和行为癌症研究能力和基础设施，并扩大伙伴机构之间的合作(预计将有500多人参加讲习班，包括临床医生、研究人员和公共卫生人员)。拟议计划的成果将包括接受过癌症基因组学、癌症诊断、病理学和分子工具以及癌症流行病学培训的赞比亚生物医学研究人员和癌症保健提供者；帮助这些人开展工作的新基础设施和工具；以及将这些训练有素的人员留在赞比亚机构，这些人员将在完成培训后受雇于那里，那里将有一个可持续的研究基础设施，以支持赞比亚的癌症临床和研究项目。

 DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln - in collaboration with Zambian partners - has been administering a NIH Fogarty International Center Training Program to develop the infrastructure and research capacity in Zambia to advance the prevention, diagnosis, and management of HIV- and AIDS-associated diseases since 2000. While the program has found great success in advancing these goals, it is coming to an end this year, and the partner institutions are proposing to implement a new and more focused training program to address a critical health problem in the region: AIDS-associated cancers. With the addition of a new partner, the Cancer Diseases Hospital (CDH), the goal of this program is to train a cadre of Zambian biomedical researchers and practitioners in the skills necessary to further the country's research agenda in cancer biology and prepare the country for the new era of cancer genomics for the diagnoses and treatment of cancers. The CDH - which is located on the UNZA and UTH campuses and is the only major cancer treatment center in Zambia - will serve as the main in-country low- and middle-income country institution for the proposed program. Since its establishment in 2006, the CDH has made significant advances in developing its capacity to treat and conduct research on cancer, but there remains a significant need for additional and better trained cancer researchers and oncologists. To train and retain such personnel in Zambia, the program design is organized around the following specific aims, each focused on different types of training: 1) Provide intensive academic instruction and research experience for four Zambian fellows to receive an MSc, MPH, or MMed degree in a relevant cancer research field (two years of training for each fellow); 2) Provide intensive academic instruction and research experience for two Zambian fellows leading to receipt of a PhD in a relevant cancer research field (five years of training for each fellow); 3) Provide medium-term (six months) technical training opportunities for five post-graduates in topics related to molecular pathology, cancer biology, and genomics; and 4) Deliver workshops designed to enhance basic, clinical, implementation, and behavioral cancer research capability and infrastructure in Zambia and expand collaborations among the partner institutions (over 500 total workshop participants are expected, including clinicians, researchers, and public health personnel). The outcomes of the proposed program will include Zambian biomedical researchers and cancer healthcare providers trained in cancer genomics, cancer diagnostics, pathology and molecular tools, and cancer epidemiology; new infrastructure and tools to aid these individuals in their work; and the retention of these trained personnel at Zambian institutions, where will be employed upon the completion of their training where there will be a sustainable research infrastructure to support cancer clinical and research programs in Zambia.