Administrative Core

摘要/项目摘要 拟议联盟的研究主题集中在癌症的早期发现，破译癌症 卡波西肉瘤和眼表的发病机制及潜在生物标志物的鉴定 鳞状肿瘤(OSSN)，赞比亚最常见的两种与艾滋病相关的癌症。赞比亚 艾滋病恶性疾病诊断和发病计划(ZAMDAPP)的S目标，该目标将把关键专业知识和 赞比亚内布拉斯加州林肯大学内布拉斯加州病毒学中心资源 大学教学医院和赞比亚癌症医院(CDH)正在开发CDH癌症 对财团整体研究主题至关重要的三个领域的研究基础设施：癌症诊断、病毒 肿瘤学和癌症治疗。行政核心将提供行政和方案 确保财团高效运作所需的领导力和基础设施。这个 行政核心将追求四个具体目标：1)提供行政专业知识和资源 支持该联盟的职业提升核心、共享资源核心和研究所必需的 项目以实现其目标和具体目的；2)在整个联合体范围内实施一系列 旨在创建协作研究环境和建设以下能力的操作流程 提高赞比亚卫生机构的自给自足能力；3)提供通信基础设施 主要利益相关者并在当地和全球范围内推动财团；以及4)建立和培育强大的 与外部咨询小组的工作关系，该小组由主要利益攸关方和专业领导人组成，以 将研究工作与赞比亚社区联系起来，并确定将为健康提供信息的研究成果 政策变化。行政核心的组织设计为响应、包容和 稳健，这对于成功处理内部广泛的任务和复杂的关系是必不可少的 ZAMDAPP，在伙伴关系和合作机构之间，以及与NIH。这一核心将专注于满足 伙伴关系和合作者在当前快速变化的科学和技术环境中的需求 技术进步，这将导致一个具有活力的研究项目的可持续联盟 为减少非洲的癌症而努力。

ABSTRACT/PROJECT SUMMARY The research theme of the proposed consortium focuses on the early detection of cancer, deciphering cancer pathogenesis, and the identification of potential biomarkers of Kaposi’s Sarcoma (KS) and ocular surface squamous neoplasia (OSSN), two of the most prevalent AIDS-associated cancers in Zambia. The Zambia AIDS Malignancies Diagnosis and Pathogenesis Program (ZAMDAPP)’s goal, which will link key expertise and resources of the Nebraska Center for Virology at the University of Nebraska-Lincoln, University of Zambia University Teaching Hospital, and Zambia’s Cancer Disease Hospital (CDH), is to develop the CDH cancer research infrastructure in three areas critical to the consortium’s overall research theme: cancer diagnosis, viral oncology, and cancer treatment. An Administrative Core will provide the administrative and programmatic leadership and infrastructure necessary to ensure the consortium functions efficiently and effectively. The Administrative Core will pursue four specific aims: 1) provide the administrative expertise and resources necessary to support the consortium’s Career Enhancement Core, Shared Resources Cores, and research projects in the accomplishment of their goals and specific aims; 2) implement a consortium-wide series of operational processes designed to create a collaborative research environment and build capacity for increased self-sufficiency in Zambian health institutions; 3) provide communications infrastructure to engage key stakeholders and promote the consortium locally and globally; and 4) establish and cultivate a strong working relationship with an External Advisory Group composed of key stakeholders and expertise leaders to connect research efforts with Zambian communities and identify research outcomes that will inform healthy policy changes. The organization of the Administrative Core is designed to be responsive, inclusive, and robust, which is essential to successfully address the broad mission and complex relationships within ZAMDAPP, among partnering and collaborating institutions, and with NIH. This core will focus on meeting the needs of the partnership and collaborators in the current climate of rapidly changing scientific and technological advances, which will result in a sustainable consortium with vibrant research programs that work toward the reduction of cancer in Africa.