Admin Core

管理核心

• 批准号: 10598770
• 负责人: Charles Wood
• 金额: $ 28.51万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598770
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; African; Biological Markers; Cancer Center; Caring; Chronic Disease; Climate; Clinical; Collaborations; Communication; Complex; Country; Detection; Development; Diagnosis; Diagnostic; Disease; Ensure; Environment; Goals; Group Meetings; HIV; HIV-1; Health Sciences; Hospitals; Human Herpesvirus 8; Immune response; Immunologics; Immunosuppression; Individual; Information Dissemination; Infrastructure; Institution; International; Kaposi Sarcoma; Leadership; Location; Louisiana; Malignant Neoplasms; Mission; Oceans; Outcome; Outcomes Research; Pathogenesis; Persons; Pilot Projects; Policies; Prevention; Process; Research; Research Activity; Research Infrastructure; Research Project Grants; Resource Sharing; Resources; Series; Tanzania; Teaching Hospitals; Technology; Tissues; Training; United States; United States National Institutes of Health; Universities; Viral; Viral reservoir; Virus Latency; Work; Zambia; anticancer research; antiretroviral therapy; career development; data dissemination; data integration; data management; data sharing; design; experience; improved; meetings; metabolomics; prevent; programs; success; synergism

A multi-institutional, international, and integrated endeavor, the “KS in the Era of ART in Africa Program (KEAAP)” will leverage the research and training expertise of collaborating institutions from the U.S. and two African countries: the Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO), the Cancer Diseases Hospital (CDH) and the University Teaching Hospitals (UTH) of Zambia, and the Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania to form an HIV-Associated Malignancy Research Center (HAMRC) that focuses on the research gaps of the Kaposi sarcoma (KS) disease. Building on the success of their previous collaborations, these institutions will synergize their efforts under one overarching research theme that focuses on the KS disease spectrum, from detection, to care and outcomes, to deciphering KS pathogenesis and immune response. The immediate goal is to 1) implement a program to better integrate KS diagnostic, clinical and research activities within the HIV-1 care and treatment networks in both countries; 2) define stage- and treatment-associated immunologic and metabolomics biomarkers across the spectrum of KS disease presentation; and 3) define the magnitude and breadth of Kaposi sarcoma herpesvirus (KSHV) latent viral reservoirs in tissues of KSHV infected people living with HIV, so that these reservoirs could be targeted for prevention of viral reactivation to prevent KS. To achieve this goal and promote synergy and coordination across partnering institutions, KEAAP will establish an Administrative Core, based at LSUHSC-NO with satellite locations at UTH/CDH, and ORCI, that will provide the administrative support needed to ensure that KEAAP’s three research projects, Shared Resource Core (Data Management and Integration Core), and Career Development Core can accomplish their individual and collective goals while functioning in an integrated and coordinated manner. The Administrative Core will pursue four specific aims. 1) Provide the administrative expertise and resources necessary to support the consortium’s research projects and cores and the pilot projects to accomplish their goals and specific aims. 2) Implement a consortium-wide series of operational processes designed to create a collaborative research environment, promote data sharing and dissemination of results, and build capacity for increased self-sufficiency at cancer research institutions in Tanzania and Zambia. 3) Provide communications infrastructure to engage key stakeholders, to promote the consortium, and disseminate information and research outcomes that will inform healthy policy changes locally, and globally. The organization of the Administrative Core is designed to be responsive, inclusive, and robust – attributes that are essential to address the broad mission and complex relationships within KEAAP, among collaborating institutions, and with NIH. The core will focus on meeting the needs of the collaborators in a climate of rapidly changing scientific and technological advances in order to promote a sustainable consortium with vibrant research programs that work toward the reduction of cancer in sub-Saharan Africa.

一个多机构的、国际的和综合的努力，“非洲艺术时代的KS计划” (KEAAP)“将利用美国和两国合作机构的研究和培训专业知识 非洲国家：路易斯安那州立大学新奥尔良健康科学中心(LSUHSC-NO)， 赞比亚癌症医院(CDH)和大学教学医院(UTH)和海洋 坦桑尼亚达累斯萨拉姆的公路癌症研究所(ORCI)将成立一项与艾滋病毒相关的恶性肿瘤研究 中心(HAMRC)，专注于卡波西肉瘤(KS)疾病的研究空白。建立在 为了使它们以前的合作取得成功，这些机构将在一个总体框架下协同努力。 重点研究KS疾病谱的研究主题，从检测到护理和结果，再到 破译KS的发病机制和免疫应答。近期目标是1)实施一项计划，以 年，更好地将KS诊断、临床和研究活动纳入艾滋病毒-1护理和治疗网络 两个国家；2)定义与阶段和治疗相关的免疫和代谢组学生物标记物 KS病的表现谱；以及3)确定Kaposi肉瘤的大小和广度 疱疹病毒(KSHV)在感染了KSHV的艾滋病毒携带者组织中的潜伏病毒库，使这些 可以将水库作为预防病毒重新激活的目标，以防止KS。要实现这一目标，促进 在合作机构之间的协同和协调，KEAAP将建立一个行政核心，总部设在 LSUHSC-NO，卫星位置在UTH/CDH，以及ORCI，将提供管理支持 需要确保KEAAP的三个研究项目，共享资源核心(数据管理和 整合核心)和职业发展核心可以实现其个人和集体目标，同时 以综合和协调的方式运作。行政核心将追求四个具体目标。 1)提供必要的行政专业知识和资源，以支持该联盟的研究项目 以及核心和试点项目，以实现其目标和具体目的。2)在联合体范围内实施 旨在创建协作研究环境、促进数据共享的一系列操作流程 和传播成果，并在#年建立能力，提高癌症研究机构的自给自足能力 坦桑尼亚和赞比亚。3)提供通信基础设施以吸引关键利益攸关方参与，以促进 并传播信息和研究成果，为当地健康的政策变化提供信息， 以及全球范围内。行政核心的组织旨在响应、包容和强大-- 对于解决KEAAP内部的广泛使命和复杂关系至关重要的属性，包括 合作机构，并与NIH合作。核心将专注于满足合作者的需求 应对快速变化的科学和技术进步的气候，以促进可持续联盟 通过充满活力的研究项目，致力于减少撒哈拉以南非洲的癌症。