UAB Center for AIDS Research

阿拉巴马大学艾滋病研究中心

• 批准号: 9065697
• 负责人: Michael S. Saag
• 金额: $ 461.52万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9065697
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Address; Alabama; Area; Behavioral; Behavioral Sciences; Biometry; Caring; Chronic; Clinical; Clinical Data; Clinical Research; Collaborations; Communication; Communities; Computerized Medical Record; Culture Techniques; DNA Sequence; Data; Databases; Detection; Development; Discipline; Disease; Effectiveness; Epidemiology; Evolution; Extramural Activities; Faculty; Faculty Recruitment; Flow Cytometry; Fostering; Funding; Genomics; Grant; Growth; HIV; HIV-1; Human; Human immunodeficiency virus test; Infection; Institutes; Instruction; Interdisciplinary Study; International; Intervention; Leadership; Link; Location; Mentors; Methods; Mission; Molecular Virology; NIH Grants and Contracts; Natural History; Outcomes Research; Pathogenesis; Peer Review; Phase; Plasma; Play; Prevention; Productivity; Program Development; Publications; RNA; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk Assessment; Role; Services; Specimen; Statistical Data Interpretation; Strategic Planning; System; Therapeutic; Translational Research; United States; United States National Institutes of Health; Universities; Viral; clinical care; clinical practice; community science; drug discovery; innovation; interest; member; microbiome; minority investigator; multidisciplinary; novel; programs; psychosocial; public health relevance; success; virology; virus culture

DESCRIPTION (provided by applicant): The mission of the UAB CFAR is to support UAB investigators in the conduct of multidisciplinary, cutting edge research in the prevention, pathogenesis, therapeutics, clinical care, and psychosocial manifestations of HIV and related disorders in the community, within the US and around the world. For 25 years, the Center has played a vital role in supporting research activities of its members that have led to paradigm-shifting discoveries, including: the discovery of HIV-1 quasi-species diversity, detection of HIV-1 RNA in plasma, viral dynamics in acute and chronic infection, first-in-human phase 1 clinical studies of 7 currently approved therapies, the zoonotic origins of HIV-1, and the direct use of outcomes research data to inform clinical practice. Strategic planning activities have focused our scientific agenda over the next 5 years to address: HIV pathogeneses, the natural history of HIV in the treatment era, drug discovery, and prevention. The objectives of the CFAR reflect this modern agenda and further our commitment to innovative, multidisciplinary AIDS research, including: 1. Provision of a central institutional focus for HIV/AIDS research activities that emphasize effective communication and collaboration among CFAR members and the wider HIV/AIDS research community. 2. Enhancement of productivity of ongoing research programs by encouraging interdisciplinary research and by providing critical shared resource facilities and administrative and fiscal management support to Center investigators. 3. Use of robust strategic planning methods to identify new research opportunities and priorities that align with existing CFAR programs and foster new research programs where none are in existence but where faculty interest and University capacity is evident. 4. To stimulate the entry of junior and established faculty into HIV/AIDS research programs through mentoring programs for young investigators and by a peer-reviewed Developmental Grants Program. 5. To stimulate faculty recruitment and program development in areas that reflect the ongoing evolution of HIV/AIDS research in Alabama, the United States, and around the world. The success of the UAB CFAR in stimulating HIV/AIDS research is reflected in the growth in extramural funding from $6.0 million in 1988 to over $86 million currently, in the recruitment of more than 24 HIV/AIDS investigators since 2009, high profile publications, and in the garnering of outstanding Institutional support. .

描述（由申请人提供）：UAB CFAR 的使命是支持 UAB 研究人员在美国和世界各地的社区中开展艾滋病毒和相关疾病的预防、发病机制、治疗、临床护理和心理社会表现方面的多学科前沿研究。 25 年来，该中心在支持其成员的研究活动方面发挥了至关重要的作用，这些活动导致了范式转变的发现，包括：HIV-1 准物种多样性的发现、HIV-1 的检测 血浆中的 RNA、急性和慢性感染中的病毒动力学、7 种目前批准的疗法的首次人体 1 期临床研究、HIV-1 的人畜共患起源，以及直接使用结果研究数据来指导临床实践。战略规划活动将我们未来 5 年的科学议程重点关注：艾滋病毒发病机制、治疗时代艾滋病毒的自然史、药物发现和预防。 CFAR 的目标反映了这一现代议程，并进一步推动了我们对创新、多学科艾滋病研究的承诺，包括： 1. 为艾滋病毒/艾滋病研究活动提供一个中心机构重点，强调 CFAR 成员和更广泛的艾滋病毒/艾滋病研究界之间的有效沟通与合作。 2. 通过鼓励跨学科研究以及向中心研究人员提供重要的共享资源设施以及行政和财务管理支持，提高正在进行的研究计划的生产力。 3. 使用强有力的战略规划方法来确定与现有CFAR项目相一致的新研究机会和优先事项，并在尚不存在但教师兴趣和大学能力明显的情况下培育新的研究项目。 4. 鼓励初级和初级人员的进入 通过针对年轻研究人员的指导计划和经过同行评审的发展资助计划，建立了艾滋病毒/艾滋病研究项目的师资队伍。 5. 促进反映阿拉巴马州、美国和世界各地艾滋病毒/艾滋病研究不断发展的领域的教师招聘和项目开发。 UAB CFAR 在促进艾滋病毒/艾滋病研究方面取得的成功体现在外部资金从 1988 年的 600 万美元增长到目前的 8600 万美元以上、自 2009 年以来招募了超过 24 名艾滋病毒/艾滋病研究人员、高调出版物以及获得杰出的机构支持。 。