Thalamic cortical dysfunction and predictors of relapse in cocaine dependence

丘脑皮质功能障碍和可卡因依赖复发的预测因素

• 批准号: 9319698
• 负责人: SHENG ZHANG
• 金额: $ 16.7万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9319698
• 关键词: Address; Affective; Alcohol consumption; Algorithms; Anxiety; Award; Behavior; Behavioral; Biological Markers; Biology; Brain; Brain imaging; Cerebrum; Characteristics; Chronic; Clinical; Clinical Trials; Cluster Analysis; Cocaine; Cocaine Dependence; Cocaine Users; Cognitive; Cognitive deficits; Collaborations; Complement; Computing Methodologies; Cues; Dimensions; Doctor of Philosophy; Drug usage; Emotional; Engineering; Etiology; Experimental Psychology; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Gender; Goals; Grant; Growth; Heterogeneity; Human; Imaging Techniques; Impulsivity; Individual; Knowledge; Logistics; Mediating; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Modeling; National Institute of Drug Abuse; Neuropsychological Tests; Neurosciences; Neurosciences Research; Patients; Pattern Recognition; Personality Traits; Play; Preparation; Process; Psychophysiology; Public Health; Relapse; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Rest; Role; Seeds; Series; Structure; Substance Use Disorder; Substance abuse problem; System; Thalamic structure; Time; Training; Universities; Voice; Work; Writing; addiction; alcohol comorbidity; base; career; clinically relevant; cocaine use; cognitive control; cognitive function; cohort; craving; design; faculty research; independent component analysis; individual patient; neuroimaging; neuropsychiatric disorder; novel; public health relevance; relapse prediction; relating to nervous system; reward processing; speech processing; substance misuse; training project; treatment trial

 DESCRIPTION (provided by applicant): This application requests 5 years of funding through the K25 Mentored Quantitative Research Scientist Development Award mechanism. With a Ph.D. degree in engineering, the candidate received additional training in experimental psychology, focusing specifically on human emotional speech processing and voice pattern recognition. As a postdoctoral associate and, more recently, a research faculty at Yale University, he conducted numerous fMRI studies on healthy individuals and patients with substance use disorders. The candidate's career goals are to build on an extensive background in engineering and computation and continue to develop advanced, novel computational methods to investigate altered cerebral function and connectivity as a circuit level biomarker of substance misuse. The support of this K25 award will provide time and resources for him to solidify his knowledge of brain structure and function and facilitate an independent career in addiction neuroscience research. His training plan will cover: 1) systems, cognitive, and addiction neuroscience through formal course work and research collaboration with his mentors; 2) neuroimaging, with a specific focus on state-of-the-art imaging techniques, experimental psychology, and design of fMRI studies; 3) biology, treatment, and clinical trials research of substance abuse; 4) scientific writing; and 5) grant preparation. To implement this training plan, the candidate has assembled an outstanding team of mentors and proposed to use a novel computational approach to understand how thalamic cortical functions are compromised and how these deficits are related to relapse in chronic cocaine users. Specifically, he proposed to employ resting state and task-modulated connectivity analysis to functionally parcellate the thalamus during resting, cognitive control, reward processing and cue-induced craving, and to investigate how thalamic cortical circuit functions are altered in individuals with cocaine dependence. With the concurrent support of an ongoing R01 study, the candidate will study more than 250 cocaine dependent patients in a longitudinal setting to identify thalamic cortical predictors of relapse. The study will thus advance our understanding of the etiological processes of cocaine addiction in multiple dimensions. The study may also facilitate research of other neuropsychiatric disorders through its new conceptual and methodological platform. By completing the proposed training and research projects, the candidate will benefit extensively from the support of this K25 award in achieving his career goal to become an independent investigator in systems and addiction neuroscience research.

 描述（由申请人提供）：本申请要求通过K25指导定量研究科学家发展奖机制提供5年的资金。具有博士学位在获得工程学位后，候选人接受了实验心理学的额外培训，特别关注人类情感语音处理和语音模式识别。作为一名博士后助理，最近，他在耶鲁大学担任研究员，他对健康个体和物质使用障碍患者进行了许多fMRI研究。候选人的职业目标是建立在工程和计算的广泛背景，并继续开发先进的，新颖的计算方法，以调查改变大脑功能和连接作为物质滥用的电路水平生物标志物。这个K25奖的支持将为他提供时间和资源，巩固他对大脑结构和功能的知识，并促进成瘾神经科学研究的独立职业生涯。他的培训计划将包括：1）系统，认知和成瘾神经科学通过正式的课程工作和研究与他的导师合作; 2）神经成像，特别关注最先进的成像技术，实验心理学和功能磁共振成像研究的设计; 3）生物学，治疗和药物滥用的临床试验研究; 4）科学写作;和5）拨款准备。 为了实施本培训计划， 这位候选人组建了一个杰出的导师团队，并提出使用一种新的计算方法来了解丘脑皮质功能是如何受损的，以及这些缺陷与慢性可卡因使用者的复发如何相关。具体来说，他建议采用静息状态和任务调制的连接分析，在静息、认知控制、奖励处理和线索诱导的渴望过程中功能性地包裹丘脑，并研究可卡因依赖个体的丘脑皮层回路功能如何改变。在正在进行的R 01研究的同时支持下，候选人将在纵向环境中研究250多名可卡因依赖患者，以确定复发的丘脑皮质预测因子。因此，这项研究将促进我们对可卡因成瘾病因学过程的多维度理解。这项研究也可能通过其新的概念和方法平台促进其他神经精神疾病的研究。通过完成拟议的培训和研究项目，候选人将广泛受益于K25奖的支持，以实现他的职业目标，成为系统和成瘾神经科学研究的独立调查员。