Developmental Funds

项目摘要发展基金 在目前的拨款中，科学领导层已经改变了杰克逊实验室癌症中心(JAXCC) 循环，导致癌症病灶扩大。人类遗传学和基因组学的新专业知识紧密结合在一起 利用老鼠基因组学专业知识，支持对人类癌症基因组的复杂性进行建模的工作。积分 这一转变是通过聘用和聘用现有教师来招募新成员 具有互补的跨学科专业知识。日本宇宙航空研究开发机构扩大了其在癌症基因组学方面的能力 和癌症系统生物学，在免疫肿瘤学和肿瘤微环境方面建立了实力，以及 建立了强大的翻译合作伙伴关系，将基础研究迅速推向临床影响。这个 会员人数大幅增加，这是由于两个律师协会都加强了专注于癌症的领导层 港湾和法明顿校区，自2013年以来增加了22名新成员(目前为18名 授予周期)。 发展资金一直是推动日本宇宙航空研究开发机构的增长和生产力的关键因素。在当前 在赠款周期中，新调查员的资金用于支持九名初级教员，让他们参与到 在他们制定研究计划时，指导他们的高级领导。奖项在整个世界范围内颁发 一年，新的调查人员提交为期两年的正式计划计划。虽然对大多数人来说还为时过早，但 这些初级教员的进步和生产力表明了这种方法的有效性。这些奖项有 支持了12份出版物和14份外部赠款的工作，总额达5 064 892美元。在下一个周期中，基金 被要求支持新的调查员奖，这将由重要的机构利用 资金承诺额。计划要求在未来五年内增加4至5个初级JAXCC成员，其中 继续强调癌症基因组学和免疫肿瘤学。研究将依赖于正在进行的 开发和验证各种体内、体外和硅胶系统，以模拟癌症的复杂性。 试点项目方案是实现日本宇宙航空研究开发机构战略目标计划的重要组成部分。《前辈》 领导层每年通过申请申请(RFA)确定优先事项并征求试点建议 瞄准特定的目标。项目的授予是基于科学的质量，他们对 一个或多个战略目标，以及为成熟项目争取联邦资金的计划。在上一次 在赠款周期中，17个奖项支持了导致14种出版物和14种赠款的工作，总额为7619,270美元(直接 成本)。在头两年向所有日本宇宙航空研究开发机构成员开放的2-3个新的试点项目需要资金支持 以及利用制度匹配。随着会员资格的成熟，我们将在3至5年内资助3-5个试点基金。 总而言之，发展基金将支持JAXCC促进合作和充满活力的癌症 能够推进精准癌症医学的计划。

PROJECT SUMMARY DEVELOPMENTAL FUNDS The scientific leadership has transformed The Jackson Laboratory Cancer Center (JAXCC) in the current grant cycle, resulting in an expanded cancer focus. New expertise in human genetics and genomics is tightly integrated with mouse genomics expertise, supporting work to model the complexity of the human cancer genome. Integral to this transformation was recruitment of new members through faculty hiring and engagement of existing faculty with complementary transdisciplinary expertise. The JAXCC has expanded its capabilities in cancer genomics and cancer systems biology, built strength in immuno-oncology and the tumor microenvironment, and established robust translational partnerships to move basic research quickly towards clinical impact. The membership has expanded profoundly, driven by a strengthened, cancer-focused leadership on both the Bar Harbor and Farmington campuses, which saw the addition of 22 new members since 2013 (18 in the current grant cycle). Developmental funds have been crucial factors in fueling the JAXCC's growth and productivity. In the current grant cycle, New Investigator funds were used to support nine junior faculty members, engaging them with the Senior Leaders who mentored them as they developed their research plans. Awards are made throughout the year with new investigators submitting a formal program plan for a two-year award. While still early for most, the progress and productivity of these junior faculty point to the efficacy of this approach. These awards have supported work leading to 12 publications and 14 external grants totaling $5,064,892. In the next cycle, funds are requested for support of new investigator awards, which will be leveraged by significant institutional commitment of funds. Plans call for adding 4 to 5 new junior-level JAXCC members in the next five years, with a continuing emphasis on cancer genomics and immuno-oncology. Research will rely on the ongoing development and validation of a variety of in vivo, ex vivo, and in silico systems to model cancer complexity. The Pilot Project program is an essential part of the plan to achieve the JAXCC's strategic goals. The Senior Leadership sets priorities and solicits pilot proposals annually through a request for applications (RFA) that targets specific goals. Projects are awarded based on the quality of the science, their anticipated contribution to one or more strategic goals, and the plan for securing federal funding for the mature project. In the previous grant cycle, 17 awards have supported work leading to 14 publications and 14 grants totaling $7,619,270 (direct costs). Funds are requested to support 2-3 new pilot projects in the first 2 years, open to all JAXCC members and leveraging institutional match. As the membership matures, we will fund 3-5 pilot funds in years 3 to 5. Taken together, the Developmental Funds will support the JAXCC in fostering a collaborative and dynamic cancer program capable of advancing precision cancer medicine.