Genome Technologies

引言 杰克逊实验室(J/\X)成立于1929年，是一家独立的非营利性机构，致力于哺乳动物遗传学及其在精密医学中的应用方面的研究和教育，并通过访问我们的遗传资源来增强其科学事业中的其他人的能力。日本宇宙航空研究开发机构癌症研究中心(JAXCC)包括实验室的癌症研究和教育活动，以及用于癌症研究的机构共享资源。向外部研究社区提供小鼠的大规模分布菌落由一个名为JAX MICE&Services的管理机构独立于JAXCC管理。分销群体在财务上是自给自足的，作为一个非营利性组织，产生的盈余支持基础研究。 如下所述，日本宇宙航空研究开发中心在三个日本宇宙航空研究开发机构园区内设有设施。JAX的主园区位于缅因州巴尔港，占地约750,000英尺[2]。我们启动了一项重大扩张计划，在康涅狄格州法明顿开设了一个毗邻康涅狄格大学健康中心(UCHC)的校区。这个名为杰克逊基因组医学实验室的新园区将是一个18.9万英尺的设施，将于2014年完工。日本宇宙航空研究开发中心的成员主要研究人类癌症基因组学、计算生物学及其在精确医学中的应用。第三个园区是位于加利福尼亚州萨克拉门托的JAX-West设施，现已扩大到包括患者来源的异种移植(PDX)原发人类癌症的大型协作资源，显著增强了JAXCC的癌症资源。巴尔港的原校区已更名为杰克逊哺乳动物遗传学实验室(JAX哺乳动物遗传学)，以反映其在扩大的三校区框架内的作用。总体而言，我们拥有一个拥有卓越基础设施的机构，可以在哺乳动物遗传学领域进行创新和开展科学研究。校园的地理分布特性对我们有利，因为我们能够利用地方(州)资源和人才，但领导力、组织以及我们对遗传学和基因组学的关注使其统一起来。

Introduction The Jackson Laboratory (J/\X) founded in 1929, is an independent, nonprofit institute dedicated to research and education in mammalian genetics and its application to precision medicine, as well as to empowering others in their scientific enterprise through access to our genetic resources. The JAX Cancer Center (JAXCC) comprises the cancer research and education activities at the Laboratory, as well as institutional shared resources that are used in cancer research. The large-scale distribution colonies that supply mice to the external research community are managed independently from the JAXCC by an administrative arm called JAX Mice & Services. The distribution colonies are financially self-supporting and, as a not-for-profit organization, generate surpluses that support fundamental research. The JAXCC occupies facilities on three JAX campuses, described below. The main JAX campus is an ~ 750,000 ft[2] facility in Bar Harbor Maine. We have launched a major expansion with the opening of a campus adjacent to the University of Connecticut Health Center (UCHC) in Farmington, Connecticut. This new campus, called The Jackson Laboratory for Genomic Medicine (JAX Genomic Medicine), will be a 189,000 ft[2] facility, to be completed in 2014. JAXCC members on this campus focus on human cancer genomics, computational biology and their application for precision medicine. The third campus, the JAX-West facility in Sacramento, California¿has expanded to include a large, collaborative resource of patient-derived xenografted (PDX) primary human cancers, significantly enhancing the cancer resources ofthe JAXCC. The original campus in Bar Harbor has been renamed The Jackson Laboratory for Mammalian Genetics (JAX Mammalian Genetics) to reflect its role within the expanded three-campus framework. In total, we have an institution that has remarkable infrastructure to innovate and conduct science in mammalian genetics. The geographically distributed nature ofthe campuses is to our advantage in being able to capitalize on local (state) resources and talent, but unified by leadership, organization, and our focus on genetics and genomics.