Exercise training to improve cognitive function_523_Sparrow

运动训练改善认知功能_523_Sparrow

• 批准号: 9910068
• 负责人: DAVID W. SPARROW
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910068
• 关键词: Adherence; Age-Years; Alzheimer' s Disease; American; Apolipoproteins; Caring; Clinical; Complex; Computers; Control Groups; Coupled; Data; Educational Intervention; Episodic memory; Exercise; Feasibility Studies; Future; Health education; Home environment; Individual; Insulin-Like Growth Factor I; Intervention; Link; Measures; Mediating; Mediation; Mediator of activation protein; Memory; Memory impairment; Methods; Modification; Outcome Measure; Patients; Persons; Pharmacology; Phase; Process; Sample Size; Sampling; Serum; Sparrows; Symptoms; Technology; Telephone; Testing; Time; Veterans; Voice; base; carrier status; cognitive function; exercise intervention; exercise program; exercise training; fitness; improved; interest; intervention program; mild cognitive impairment; novel; pre-clinical; programs; resistance exercise; response; strength training; virtual

Project Background/Rationale. Alzheimer's disease (AD) afflicts nearly 6 million Americans, a number projected to grow in coming decades. AD is known to have a long preclinical phase in which pathophysiologic processes develop many years, even decades, before the onset of clinical symptoms. During this preclinical phase there is evidence of unremitting decline in cognitive function, particularly in episodic memory. Thus far, evidence of the efficacy of pharmacological interventions to slow this decline in cognitive function has been limited, leading to increasing interest in the utility of nonpharmacological interventions including exercise. Project Objectives. We propose to assess the feasibility of a novel home-based exercise intervention to improve episodic memory that uses resistance training coupled with real-time guidance delivered remotely in 60 individuals 50 years of age or older with mild cognitive impairment. Preliminary data on outcome measures (Rey-Osterrieth Complex Figure Test, Wechsler Logical Memory Test), a potential mediator (insulin-like growth factor-1), and a potential moderator (apolipoprotein EƐ4) will be obtained. Project Methods. We will estimate the difference between the intervention (n=30) and the control group (n=30) on 6-month change in episodic memory (Rey-Osterrieth Complex Figure Test, Wechsler Logical Memory Test) as well as the effect size, which will be used as a basis for sample size calculation for a proposed larger study. In addition, we will explore 6-month change in serum insulin-like growth factor-1 concentration during the resistance exercise program as a potential mediator of exercise-related changes in episodic memory. Further, we will explore apolipoprotein EƐ4 carrier status (carrier/noncarrier) as a potential moderator.

项目背景/理由。阿尔茨海默氏病（AD）遭受了近600万美国人的困扰 预计在未来几十年中成长。已知AD具有长长的临床前阶段，其中病理生理学 在临床症状发作之前，过程发展了很多年，甚至几十年。在此临床前 阶段有证据表明认知功能下降不舒服，尤其是在情节记忆中。那远， 药物干预措施降低这种认知功能下降的效率的证据已经是 限制，导致人们对非药理干预措施（包括运动）的效用增加了兴趣。 项目目标。我们建议评估新型家庭运动干预的可行性 改善采用电阻训练的情节记忆以及远程交付的实时指导 60个50岁或以上的人患有轻度认知障碍。有关结果度量的初步数据 （Rey-Stosterrieth复杂人物测试，Wechsler逻辑记忆测试），潜在的介体（胰岛素样生长 将获得因子1），并获得潜在的主持人（载脂蛋白Eɛ4）。 项目方法。我们将估计干预措施（n = 30）和对照组（n = 30）之间的差异 关于情节记忆的6个月更改（Rey-stosterrieth复杂人物测试，Wechsler逻辑记忆测试） 以及效应大小（将用作拟议的较大研究的样本计算基础）。 此外，我们将探索血清胰岛素样生长因子1浓度的6个月变化 阻力运动计划是情节记忆中与运动相关的变化的潜在中介。更远， 我们将探索载脂蛋白Eɛ4载体状态（载体/非载波）作为潜在的主持人。