Mentored Patient Oriented Research in Kidney Disease

摘要 自从2006年第一次成为肾病学助理教授以来，我一直致力于 以病人为中心的研究(POR)在肾脏病，并指导。这导致了相当大的成功。我 Am Pi获得了多个NIH R01奖项和合同，并领导了肾脏病的临床试验。关于…… 指导，我目前是两名K获奖者的主要导师，另一名K获奖者的次要导师， 我还指导一名肾脏病医学博士和博士后研究员、住院医师和预科医生 博士生。一位先前的学员以PI的身份领导她自己的R01，还有几位学员已经过渡到 副教授级别。我的指导者已经成功地获得了拨款支持，并出版了HIGH 影响第一作者的手稿。然而，随着对我时间的要求越来越高，以及需要为 就我的专业努力而言，我的能力有限，无法扩大我的辅导活动。我有一大笔钱 有才华的潜在实习生，并找到非常满意的指导。同样，根据需要，我资助的研究 奖项是建立在我目前的技能和专业知识之上的。然而，我对我相信可以 变革性的，但我没有足够的能力获得研究奖项并在没有额外的 在新的感兴趣的领域进行培训。我强烈希望花更多的时间指导，以扩大我的人才库 为了获得新的研究培训，我提出了这个K24。在其中，我的目标是(1) 花时间扩大我的指导能力，在以患者为导向的研究中向有前途的初级研究员提供指导 在肾脏疾病方面，以及(2)在(A)无细胞DNA技术方面获得新的研究专门知识，(B)在 FDA生物标志物资格，以及(C)领导力和团队管理技能。

ABSTRACT Since first becoming an Assistant Professor in Nephrology in 2006, I have been deeply committed to patient oriented research (POR) in nephrology, and to mentorship. This has led to considerable successes. I am PI on multiple NIH R01 awards and contracts, and am leading clinical trials in nephrology. In regards to mentorship, I am currently primary mentor to two K awardees, secondary mentor to an additional K awardee, and am also mentoring a cadre of nephrology MD and PhD post-doctoral fellows, medical residents, and pre- doctoral students. One prior mentee is leading her own R01 as PI, and several have transitioned to the Associate Professor level. My mentees have been successful garnering grant support and publishing high impact manuscripts as first author. However, with increasing demands on my time, and with the need to fund my professional effort, I am limited in my abilities to expand my mentorship activities. I have a wealth of talented potential trainees, and find great satisfaction mentoring. Similarly, by necessity, my funded research awards are built on my current skills and expertise. Yet, I am excited about new ideas that I believe can be transformative, but am ill equipped to obtain research awards and advance these ideas without additional training in the new areas of interest. My strong desire to spend more time mentoring, to expand my pool of mentees, and to obtain new research training has led me to propose this K24. Within it, my aims are to (1) to dedicate time to expand my mentorship capacities to promising junior investigators in patient oriented research in kidney disease, and (2) to obtain new research expertise in (a) cell free DNA technology, (b) approaches to FDA biomarker qualification, and (c) leadership and team management skills.