Adult and Pediatric Nephrology Clinical Investigation Training Program

成人和儿童肾脏病临床研究培训计划

• 批准号: 9904612
• 负责人: Joachim H Ix
• 金额: $ 15.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9904612
• 关键词: Adult; Childhood; Nephrology; Training Programs; clinical investigation

 DESCRIPTION (provided by applicant): The objective of our T32 grant entitled is to rigorously train clinically oriented post-doctoral scholars from both adult and pediatric backgrounds in clinical investigation focused on prevention and treatment of kidney disease. The training program strives to supplying the workforce with outstanding clinical investigators in adult and pediatric nephrology who will lead the field in discovery of new treatments and preventive strategies for the expanding population of adult and pediatric kidney disease patients throughout their careers. The training will be provided through four structured modules, supplemented by elective coursework, seminars, and individual mentoring. The first module provides a 2-year mentored primary research project, supervised by a T32 faculty member and a 3-faculty Scholar Oversight Committee created individually for each scholar. This T32 places a strong emphasis on training in epidemiology and biostatistics, which will assist scholars regardless of their primary focus within clinical investigation. Thus, in the second module, all scholars will complete the UCSD CREST program; a highly rated and successful two-year Master's program in clinical research that is specifically designed to train clinically oriented scholars in research methods. Understanding the key aspects to measurement, including topics such as precision, limits of detection, and different platforms of measurement are key tools in clinical investigation. Moreover, skills to test the kidney's ability to metabolize and clear compounds will be necessary if scholars are to deliver new treatments to kidney disease patients. Thus, the third module is designed to provide the scholar hands-on experiences with in vivo pharmacology and measurement methods in both animal models and in humans. Finally, success in investigative careers requires skills in scientific writing, grantsmanship, and leadership; structured training i these areas is often overlooked. Thus, the fourth module will provide structured training in these areas. In proposing a new T32, we have specifically designed this grant with a modest request of post-doctoral fellow positions. We request 2 slots in year 1 and 3 slots in subsequent years. One in every 3 scholars will be trained in pediatric nephrology. Recognizing the importance of strong commitment of our faculty to a new T32, we have prioritized the quality and breadth of expertise of faculty, rather than quantity of faculty. The faculty was selected based on their commitment to clinical investigation, commitment to mentorship, and breadth of expertise in all aspects of clinical investigation spanning from physiology and pharmacology in animal models to clinical trials in humans. The scholar and faculty are supported by the great wealth of expertise of the larger faculty at UCSD which will be used to supplement needs of individual scholars. In aggregate, we propose an innovative, supportive environment for outstanding training in all aspects required for successful careers in clinical investigation in adult and pediatric nephrology.

 描述（由申请人提供）：我们的 T32 补助金的目的是严格培训来自成人和儿科背景的临床博士后学者，从事以预防和治疗肾脏疾病为重点的临床研究。该培训计划致力于为劳动力提供成人和儿童肾脏病学方面的杰出临床研究人员，他们将在整个职业生涯中为不断扩大的成人和儿童肾脏疾病患者群体发现新的治疗方法和预防策略，从而引领该领域。培训将通过四个结构化模块提供，并辅以选修课程、研讨会和个人指导。第一个模块提供为期 2 年的指导性主要研究项目，由一名 T32 教职人员和为每位学者单独创建的 3 名教职人员学者监督委员会监督。该 T32 非常重视流行病学和生物统计学方面的培训，这将为学者提供帮助，无论他们在临床研究中的主要关注点是什么。因此，在第二个模块中，所有学者将完成 加州大学圣地亚哥分校 CREST 计划；一个备受好评且成功的为期两年的临床研究硕士课程，专门为培训临床学者的研究方法而设计。了解测量的关键方面，包括精度、检测限和不同测量平台等主题，是临床研究的关键工具。此外，如果学者们要为肾病患者提供新的治疗方法，那么测试肾脏代谢和清除化合物的能力的技能将是必要的。因此，第三个模块旨在为学者提供动物模型和人类体内药理学和测量方法的实践经验。最后，研究生涯的成功需要科学写作、资助和领导能力；这些领域的结构化培训经常被忽视。因此，第四个模块将提供这些领域的结构化培训。在提出新的 T32 时，我们专门设计了这笔补助金，对博士后研究员职位提出了适度的要求。我们要求第一年有 2 个名额，随后几年有 3 个名额。三分之一的学者将接受儿科肾脏病学培训。认识到我们的教师对新 T32 的坚定承诺的重要性，我们优先考虑教师专业知识的质量和广度，而不是教师的数量。选择该教师的依据是他们对临床研究的承诺、对指导的承诺以及从动物模型的生理学和药理学到人类临床试验的临床研究各个方面的专业知识的广度。学者和教师得到了加州大学圣地亚哥分校教师的丰富专业知识的支持，这些专业知识将用于补充个别学者的需求。总的来说，我们提出了一个创新的、支持性的环境，为成人和儿科肾病临床研究成功职业所需的各个方面提供出色的培训。

项目成果

Flank pain and gross hematuria: an uncommon presentation of a rare disease: Answers.

胁腹痛和肉眼血尿：罕见疾病的罕见表现：答案。

• DOI: 10.1007/s00467-020-04900-0
• 发表时间: 2021
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Allred,ErikaT;Yorgin,PeterD
• 通讯作者: Yorgin,PeterD

Flank pain and gross hematuria: an uncommon presentation of a rare disease: Questions.

• DOI: 10.1007/s00467-020-04889-6
• 发表时间: 2021-07
• 期刊: Pediatric nephrology (Berlin, Germany)
• 作者: Allred ET;Yorgin PD
• 通讯作者: Yorgin PD

De Novo Postinfectious Glomerulonephritis Secondary to Nephritogenic Streptococci as the Cause of Transplant Acute Kidney Injury: A Case Report and Review of the Literature.

• DOI: 10.1155/2018/2695178
• 发表时间: 2018
• 期刊: Case reports in transplantation
• 作者: Bullen A;Shah MM
• 通讯作者: Shah MM