Adult and Pediatric Nephrology Clinical Investigation Training Program

 描述(由申请人提供)：我们的T32资助的目标是严格培训成人和儿科背景的临床博士后学者，从事以预防和治疗肾脏疾病为重点的临床研究。该培训计划致力于为工作人员提供优秀的成人和儿童肾脏病临床研究人员，他们将在为不断扩大的成人和儿童肾脏疾病患者的职业生涯发现新的治疗方法和预防策略方面引领该领域的发展。培训将通过四个结构化模块提供，并辅之以选修课程、研讨会和个人指导。第一个单元提供一个为期两年的有指导的初级研究项目，由一名T32教员和一个为每个学者单独创建的三名教员组成的学者监督委员会监督。这本T32非常强调流行病学和生物统计学方面的培训，这将帮助学者，无论他们在临床调查中的主要重点。因此，在第二单元中，所有学者将完成 加州大学圣迭戈分校的CREST项目；这是一个在临床研究方面获得高度评价和成功的两年制硕士项目，专门为临床定向学者提供研究方法方面的培训。了解测量的关键方面，包括精密度、检测极限和不同的测量平台等主题，是临床研究的关键工具。此外，如果学者们要为肾病患者提供新的治疗方法，测试肾脏代谢和清除化合物的能力的技能将是必要的。因此，第三个模块旨在为学者提供动物模型和人类体内药理学和测量方法的实践经验。最后，在调查职业生涯中取得成功需要科学写作、勇气和领导力方面的技能；在这些领域进行系统的培训往往被忽视。因此，第四单元将在这些领域提供有系统的培训。在提出新的T32的建议时，我们特别设计了这项拨款，并适度要求博士后研究员职位。我们要求在第一年提供2个名额，并在随后几年申请3个名额。每3名学者中就有1名将接受儿科肾病方面的培训。认识到我们的教员对新T32的坚定承诺的重要性，我们优先考虑教员的专业知识的质量和广度，而不是教员的数量。这些教师是根据他们对临床研究的承诺、对指导的承诺以及从动物模型的生理学和药理学到人类临床试验的临床研究方方面面的专业知识而被挑选出来的。加州大学圣迭戈分校规模较大的教员拥有丰富的专业知识，这些专业知识将用于补充个别学者的需求，为学者和教师提供支持。总之，我们提出了一个创新的、支持性的环境，为成人和儿童肾脏病临床研究的成功职业所需的所有方面的杰出培训提供支持。

 DESCRIPTION (provided by applicant): The objective of our T32 grant entitled is to rigorously train clinically oriented post-doctoral scholars from both adult and pediatric backgrounds in clinical investigation focused on prevention and treatment of kidney disease. The training program strives to supplying the workforce with outstanding clinical investigators in adult and pediatric nephrology who will lead the field in discovery of new treatments and preventive strategies for the expanding population of adult and pediatric kidney disease patients throughout their careers. The training will be provided through four structured modules, supplemented by elective coursework, seminars, and individual mentoring. The first module provides a 2-year mentored primary research project, supervised by a T32 faculty member and a 3-faculty Scholar Oversight Committee created individually for each scholar. This T32 places a strong emphasis on training in epidemiology and biostatistics, which will assist scholars regardless of their primary focus within clinical investigation. Thus, in the second module, all scholars will complete the UCSD CREST program; a highly rated and successful two-year Master's program in clinical research that is specifically designed to train clinically oriented scholars in research methods. Understanding the key aspects to measurement, including topics such as precision, limits of detection, and different platforms of measurement are key tools in clinical investigation. Moreover, skills to test the kidney's ability to metabolize and clear compounds will be necessary if scholars are to deliver new treatments to kidney disease patients. Thus, the third module is designed to provide the scholar hands-on experiences with in vivo pharmacology and measurement methods in both animal models and in humans. Finally, success in investigative careers requires skills in scientific writing, grantsmanship, and leadership; structured training i these areas is often overlooked. Thus, the fourth module will provide structured training in these areas. In proposing a new T32, we have specifically designed this grant with a modest request of post-doctoral fellow positions. We request 2 slots in year 1 and 3 slots in subsequent years. One in every 3 scholars will be trained in pediatric nephrology. Recognizing the importance of strong commitment of our faculty to a new T32, we have prioritized the quality and breadth of expertise of faculty, rather than quantity of faculty. The faculty was selected based on their commitment to clinical investigation, commitment to mentorship, and breadth of expertise in all aspects of clinical investigation spanning from physiology and pharmacology in animal models to clinical trials in humans. The scholar and faculty are supported by the great wealth of expertise of the larger faculty at UCSD which will be used to supplement needs of individual scholars. In aggregate, we propose an innovative, supportive environment for outstanding training in all aspects required for successful careers in clinical investigation in adult and pediatric nephrology.