Adult and Pediatric Nephrology Clinical Investigation Training Program

 描述（由申请人提供）：我们的T32资助的目标是严格培训临床导向的博士后学者，他们来自成人和儿科背景，从事肾脏疾病预防和治疗的临床研究。该培训计划致力于为成人和儿童肾脏病学的优秀临床研究人员提供劳动力，他们将在整个职业生涯中为不断扩大的成人和儿童肾脏疾病患者发现新的治疗方法和预防策略。培训将通过四个结构化模块提供，并辅以选修课程、研讨会和个人辅导。第一个模块提供了一个为期2年的指导主要研究项目，由T32教师和3教师学者监督委员会为每个学者单独创建的监督。这个T32非常重视流行病学和生物统计学的培训，这将有助于学者，无论他们在临床调查的主要重点。因此，在第二模块中，所有学员都将完成 UCSD CREST项目;一个高度评价和成功的为期两年的硕士课程，在临床研究，是专门设计用于培养临床导向的学者在研究方法。了解测量的关键方面，包括精密度、检测限和不同的测量平台等主题，是临床研究的关键工具。此外，如果学者们要为肾病患者提供新的治疗方法，测试肾脏代谢和清除化合物的能力将是必要的。因此，第三个模块旨在为学者提供动物模型和人类体内药理学和测量方法的实践经验。最后，在调查职业生涯中取得成功需要科学写作，语法和领导能力的技能;这些领域的结构化培训往往被忽视。因此，第四单元将提供这些领域的结构化培训。在提出一个新的T32，我们专门设计了这个补助金与博士后研究员职位的适度要求。我们要求第一年有2个名额，随后几年有3个名额。每3名学者中就有1名将接受儿科肾脏学培训。认识到我们的教师对新的T32的坚定承诺的重要性，我们优先考虑教师的专业知识的质量和广度，而不是教师的数量。该学院的选择是基于他们对临床研究的承诺，对导师的承诺，以及从动物模型的生理学和药理学到人类临床试验的临床研究各个方面的专业知识。学者和教师得到了UCSD更大教师的大量专业知识的支持，这些专业知识将用于补充个别学者的需求。总的来说，我们提出了一个创新的，支持性的环境，在成人和儿童肾脏病临床研究成功的职业生涯所需的各个方面进行出色的培训。

 DESCRIPTION (provided by applicant): The objective of our T32 grant entitled is to rigorously train clinically oriented post-doctoral scholars from both adult and pediatric backgrounds in clinical investigation focused on prevention and treatment of kidney disease. The training program strives to supplying the workforce with outstanding clinical investigators in adult and pediatric nephrology who will lead the field in discovery of new treatments and preventive strategies for the expanding population of adult and pediatric kidney disease patients throughout their careers. The training will be provided through four structured modules, supplemented by elective coursework, seminars, and individual mentoring. The first module provides a 2-year mentored primary research project, supervised by a T32 faculty member and a 3-faculty Scholar Oversight Committee created individually for each scholar. This T32 places a strong emphasis on training in epidemiology and biostatistics, which will assist scholars regardless of their primary focus within clinical investigation. Thus, in the second module, all scholars will complete the UCSD CREST program; a highly rated and successful two-year Master's program in clinical research that is specifically designed to train clinically oriented scholars in research methods. Understanding the key aspects to measurement, including topics such as precision, limits of detection, and different platforms of measurement are key tools in clinical investigation. Moreover, skills to test the kidney's ability to metabolize and clear compounds will be necessary if scholars are to deliver new treatments to kidney disease patients. Thus, the third module is designed to provide the scholar hands-on experiences with in vivo pharmacology and measurement methods in both animal models and in humans. Finally, success in investigative careers requires skills in scientific writing, grantsmanship, and leadership; structured training i these areas is often overlooked. Thus, the fourth module will provide structured training in these areas. In proposing a new T32, we have specifically designed this grant with a modest request of post-doctoral fellow positions. We request 2 slots in year 1 and 3 slots in subsequent years. One in every 3 scholars will be trained in pediatric nephrology. Recognizing the importance of strong commitment of our faculty to a new T32, we have prioritized the quality and breadth of expertise of faculty, rather than quantity of faculty. The faculty was selected based on their commitment to clinical investigation, commitment to mentorship, and breadth of expertise in all aspects of clinical investigation spanning from physiology and pharmacology in animal models to clinical trials in humans. The scholar and faculty are supported by the great wealth of expertise of the larger faculty at UCSD which will be used to supplement needs of individual scholars. In aggregate, we propose an innovative, supportive environment for outstanding training in all aspects required for successful careers in clinical investigation in adult and pediatric nephrology.