Smart Self-Sterilizing Dental Composites for Class V Restorations

用于 V 级修复的智能自消毒牙科复合材料

• 批准号: 9302387
• 负责人: Jack L. Ferracane
• 金额: $ 38.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9302387
• 关键词: Acids; Adhesives; Affect; Ammonium; Anti-Bacterial Agents; Area; Bacteria; Bacterial Attachment Site; Biological; Calcium; Cervical; Characteristics; Chemistry; Clinical; Cohort Studies; Collagen; Complex; Composite Resins; Covalent Interaction; Crosslinker; Dental; Dental Cementum; Dental Plaque; Dental caries; Dentin; Dentistry; Environment; Escherichia coli; Esters; Esthetics; Film; Fluorides; Formulation; Fracture; General Population; Gingival Recession; Glass; Goals; Healthcare; Heterogeneity; Hydrolysis; Impairment; Laboratories; Lactams; Lesion; Life; Light; Location; Longevity; Matrix Metalloproteinases; Mechanics; Medical; Methacrylates; Microbial Biofilms; Modification; Molecular Conformation; Nature; Oral; Oral cavity; Patients; Pharmaceutical Preparations; Phosphonic Acids; Plant Resins; Polymers; Population; Preparation; Procedures; Psychological reinforcement; Public Health; Recurrence; Resistance; Risk; Root Caries; Salivary; Savings; Services; Site; Stimulus; Stress; Surface; Surface Properties; System; Techniques; Technology; Temperature; Time; Tissues; Tooth structure; Translating; Underserved Population; Variant; Viscosity; Water; Work; Xerostomia; aging population; antimicrobial; bactericide; base; biomaterial compatibility; chelation; chromophore; composite restoration; cost; design; esterase; improved; innovation; killings; mechanical force; mechanical properties; medical implant; methacrylamide; monomer; novel; oral bacteria; polymerization stress; practical application; quaternary ammonium compound; remineralization; response; restoration; restorative material; seal; spiropyran

Summary Dental caries continues to be a public health issue, especially more evident in underserved populations throughout the U.S. Unfortunately, especially with an ageing population, hundreds of thousands of resin composite restorations are replaced each year due to recurring decay and fracture. According to a number of cohort studies, the average life-span of this type of restoration is 7 years or less, depending on the caries risk level of the patient and on the complexity of the restorative procedure. Class V lesions, carious or non-carious in nature, are particularly challenging to restore due to the location of the margins (often in dentin/cementum), the complexity of load distribution in this area of the tooth and the tendency for greater biofilm accumulation near cervical areas. This proposal represents an effort to develop novel pH- responsive, self-sterilizing methacrylamide composites capable of overcoming the aforementioned difficulties and increasing service life of class V restorations, thus saving millions of dollars annually and the unnecessary loss of additional tooth structure. The proposed approach will improve the longevity of class V restorations by: 1. Designing monomers, based on biocompatible carboxybetaine (CB) chemistry, that are capable of responding to acidic challenges in the oral environment and performing the dual function of antifouling surfaces (at neutral pH) and bactericidal surfaces (at low pH). 2.Utilizing polymerizable functionalities that depart from the water/esterase-labile methacrylates. Methacrylamides are well known for their resistance to degradation by hydrolysis, and the systems proposed here will also be stable to enzymatic attack (through the use of tertiary methacrylamides). 3. Incorporating toughening additives, based on pre-polymerized thiourethanes, which not only reduce the concentration of polymerizable functionalities (thus reducing shrinkage), but can also delay polymer gelation (thus reducing stress). In addition, the oligomer will be functionalized to work as a carrier of the CB moiety. 4. Promoting self-adhesive, ionic/covalent interaction between the substrate and the adhesive layer, in addition to the already existing micro-mechanical interlocking. This will allow for the use of less aggressive (if any) acid etching of the substrate, decreasing activation of deleterious MMPs.

概括 龋齿仍然是一个公共卫生问题，尤其是在服务不足的情况下更为明显 不幸的是，美国各地的人口，尤其是人口老龄化，数百人 每年由于反复衰减和 断裂。根据许多队列研究，这种类型的平均寿命 恢复是7年或更短的时间，具体取决于患者的龋齿风险水平和 修复程序的复杂性。 V级病变本质上是狂热或不谨慎的 由于边缘的位置（通常在牙本质/水泥中），还要恢复特别具有挑战性 牙齿该区域中负荷分布的复杂性和更大的生物膜的趋势 颈部附近的积累。该提议代表了开发新颖ph-的努力 响应迅速，自杀的甲基丙烯酰胺复合材料，能够克服 上述困难和增加V级修复的使用寿命，从而节省了 每年数百万美元，不必要的牙齿结构损失。提议 方法将通过以下方式改善V级修复的寿命：1。设计基于单体，基于单体 在生物相容性的羧甲烷（CB）化学上，能够对酸性做出反应 口腔环境中的挑战并执行防毒表面的双重功能（在 中性pH）和杀菌表面（在低pH值下）。 2.利用可见的功能 从水/酯酶 - 巴属甲基丙烯酸酯出发。甲基丙烯酰胺以其 通过水解对降解的抗性，此处提出的系统也将稳定 酶促攻击（通过使用三级甲基丙烯酰胺）。 3。加强 基于预聚合硫乙烷的添加剂，不仅降低了浓度 可聚合功能（从而减少收缩），但也会延迟聚合物凝胶化 （从而减少压力）。此外，将寡聚物功能化以作为载体 CB部分。 4。促进底物与底物之间的自粘性，离子/共价相互作用 除了已经存在的微机械互锁外，粘合剂层。这将允许 为了使用不太侵略性（如果有的话）底物的酸蚀刻，请降低激活的激活 有害的MMP。