UTMB Clinical and Translational Science Award

摘要 这个TL 1培训核心，在支持UTMB CTSA U 54应用程序，将提供“博士前学生（3 学生/年），具有深刻的方向转化科学，和博士后研究员（3名学者/年）， 先进的研究培训与CTSA的目标，推进治疗（药物，设备， 诊断和预防）、临床干预和行为改变以改善人类健康。” 与其他地方一样，UTMB现有的课程和培训计划擅长开发特定学科的 知识和技术技能，但在发展核心技能和基本能力方面效率较低 有效和高效的实践团队为基础的翻译科学;这些是：团队管理， 共同领导，解决冲突和谈判，跨专业沟通，创业精神， 与人类受试者研究和临床试验相关的监管和伦理问题。为了解决这个 差距，我们将建立在我们的CTSA枢纽的成功应用的混合行业“工作团队”-学术 采用多学科翻译团队（MTT）模式进行翻译研究。我们还将使用 一个培训模式，是基于我们成功实施能力驱动的课程，为新的 翻译博士课程。我们将从我们的13个生物医学领域中的任何一个足够大的受训人员库中招募 研究生课程，包括代表性不足的少数民族，这是反映了一个多元化的比例很大， 教师。最重要的是，GSBS和UTMB教务长发起并资助了以下方面的财政补充： 学生被招募为总统学者，以鼓励优秀研究生的入学。 潜在的学员将被建议与基于MTT的教师进行实验室轮换。曾经的导师 团队被选中，学生和他们的导师将申请TL 1的培训职位（博士前奖学金） 训练核心。博士后学者将专门招募到该计划由基于MTT的导师 （课程教授）。除其他外，必修课程的三个特别创新的组成部分包括： 1)跨专业转化研究设计课程，其中包括医学生和博士 学生在团队中工作; 2）临床接触计划，解决了学员的需求， 学者将在其研究的人类健康和疾病相关方面接受教育;以及3） 由科学和临床专家共同指导的论文/博士后研究项目。最后，我们 培训计划的评估将使用相关的、经过验证的评估工具，如团队工作 能力测试及其他。UTMB承诺提供主要的财政资源、空间和工作人员， 该培训核心的监督、关键核心资源、综合计划和研讨会。研究生院 基础科学部还为培训中心提供财政和基础设施支持。最后 UTMB教务长的支持信列举了当前和未来对ITS的承诺， 确保这个监督实体在我们的创新培训计划中取得成功。

ABSTRACT This TL1 Training Core, in support of the UTMB CTSA U54 application, will provide “predoctoral students (3 trainees/year) with a deep orientation to translational science, and postdoctoral fellows (3 scholars/year) with advanced research training aligned with the CTSA's goals of advancing therapeutics (drugs, devices, diagnostics and preventatives), clinical interventions, and behavioral modifications to improve human health.” Existing curricula and training programs at UTMB, as elsewhere, excel at developing discipline-specific knowledge and technical skills, but are less effective at developing the core skills and competencies essential for the effective and efficient practice of team-based translational science; these are: team management, shared leadership, conflict resolution and negotiations, interprofessional communication, entrepreneurship, and the regulatory and ethical issues associated with human subjects research and clinical trials. To address this gap, we will build on our CTSA hub's successful application of a hybrid industry “work team”-academic approach to translational research using a Multidisciplinary Translational Team (MTT) model. We will also use a training model that is based on our successful implementation of a competency-driven curriculum for a new translational PhD program. We will recruit from a sufficiently large pool of trainees in any of our 13 biomedical graduate programs, including a large proportion of underrepresented minorities, which is mirrored by a diverse faculty. Of key importance, the GSBS and the UTMB Provost initiated and fund financial supplements for students recruited as Presidential Scholars to encourage the enrollment of outstanding graduate students. Potential trainees will be advised to pursue laboratory rotations with MTT-based faculty. Once a mentoring team is selected, students and their mentors will apply for training positions (predoctoral fellowship) in the TL1 Training Core. Postdoctoral scholars will be specifically recruited to the program by MTT-based mentors (Program Faculty). Among others, three particularly innovative components of the required curriculum include: 1) the Interprofessional Translational Research Design Course, which includes medical students and PhD students working in teams; 2) the Clinical Encounters Program, which addresses the need for trainees and scholars to be educated in the human health- and disease-related aspects of their research; and 3) dissertation/postdoctoral research projects co-mentored by both scientific and clinical experts. Lastly, our training program's evaluations will use relevant, validated assessment tools such as the Teamwork Competency Test and others. Primary financial resources, space, and staff are committed by UTMB to provide oversight, key core resources, integrative programs and seminars for this Training Core. The Graduate School of Basic Sciences also provides financial and infrastructure support for the Training Core. Lastly, the supporting letter from the UTMB Provost enumerates the current and future commitments to the ITS, which assure the success of this oversight entity for our innovative training program.