UTMB Clinical and Translational Science Award

摘要 这个TL1培训核心，支持UTMB CTSA U54申请，将提供“博士前学生(3 实习生/年)，深入研究翻译科学；博士后研究员(3名学者/年) 高级研究培训与CTSA推进治疗学(药物、设备、 诊断和预防)、临床干预和行为改变，以改善人类健康。 与其他地方一样，UTMB现有的课程和培训计划擅长制定特定学科的课程和培训计划 知识和技术技能，但在发展必要的核心技能和能力方面效率较低 以团队为基础的翻译科学的有效和高效实践；这些是：团队管理， 共享领导力、冲突解决和谈判、跨专业交流、企业家精神和 与人类受试者研究和临床试验相关的监管和伦理问题。要解决这个问题 GAP，我们将建立在我们的CTSA中心成功应用混合行业“工作组”的基础上--学术 采用多学科翻译团队(MTT)模式进行翻译研究。我们还将使用 基于我们成功实施能力驱动的新课程的培训模式 翻译博士项目。我们将从足够多的受训人员中招募13个生物医学专业中的任何一个 研究生课程，包括很大比例的代表不足的少数族裔，这与多样化的 教职员工。最重要的是，GSBS和UTMB教务长发起并资助了 招募学生为总统学者，鼓励优秀研究生入学。 潜在的受训者将被建议与以四甲基偶氮唑蓝为基础的教员进行实验室轮换。曾经是一名导师 团队被选中，学生和他们的导师将申请TL1中的培训职位(博士前奖学金) 培训核心。博士后学者将由基于MTT的导师专门招募到该项目中 (计划学院)。除其他外，必修课程的三个特别创新的组成部分包括： 1)跨专业翻译研究设计课程，包括医学生和博士生 学生以小组形式工作；2)临床接触计划，该计划解决了对受训人员和 对学者进行与人类健康和疾病相关的研究方面的教育；以及 由科学和临床专家共同指导的论文/博士后研究项目。最后，我们的 培训计划的评估将使用相关的、经过验证的评估工具，如团队合作 能力测试和其他。UTMB承诺提供主要的财政资源、空间和人员 监督，关键核心资源，综合计划和研讨会，为该培训核心。研究生院 基础科学部还为培训核心提供资金和基础设施支持。最后， UTMB教务长的支持信列举了目前和未来对智能交通运输系统的承诺，其中 确保这个监督实体在我们的创新培训计划中取得成功。

ABSTRACT This TL1 Training Core, in support of the UTMB CTSA U54 application, will provide “predoctoral students (3 trainees/year) with a deep orientation to translational science, and postdoctoral fellows (3 scholars/year) with advanced research training aligned with the CTSA's goals of advancing therapeutics (drugs, devices, diagnostics and preventatives), clinical interventions, and behavioral modifications to improve human health.” Existing curricula and training programs at UTMB, as elsewhere, excel at developing discipline-specific knowledge and technical skills, but are less effective at developing the core skills and competencies essential for the effective and efficient practice of team-based translational science; these are: team management, shared leadership, conflict resolution and negotiations, interprofessional communication, entrepreneurship, and the regulatory and ethical issues associated with human subjects research and clinical trials. To address this gap, we will build on our CTSA hub's successful application of a hybrid industry “work team”-academic approach to translational research using a Multidisciplinary Translational Team (MTT) model. We will also use a training model that is based on our successful implementation of a competency-driven curriculum for a new translational PhD program. We will recruit from a sufficiently large pool of trainees in any of our 13 biomedical graduate programs, including a large proportion of underrepresented minorities, which is mirrored by a diverse faculty. Of key importance, the GSBS and the UTMB Provost initiated and fund financial supplements for students recruited as Presidential Scholars to encourage the enrollment of outstanding graduate students. Potential trainees will be advised to pursue laboratory rotations with MTT-based faculty. Once a mentoring team is selected, students and their mentors will apply for training positions (predoctoral fellowship) in the TL1 Training Core. Postdoctoral scholars will be specifically recruited to the program by MTT-based mentors (Program Faculty). Among others, three particularly innovative components of the required curriculum include: 1) the Interprofessional Translational Research Design Course, which includes medical students and PhD students working in teams; 2) the Clinical Encounters Program, which addresses the need for trainees and scholars to be educated in the human health- and disease-related aspects of their research; and 3) dissertation/postdoctoral research projects co-mentored by both scientific and clinical experts. Lastly, our training program's evaluations will use relevant, validated assessment tools such as the Teamwork Competency Test and others. Primary financial resources, space, and staff are committed by UTMB to provide oversight, key core resources, integrative programs and seminars for this Training Core. The Graduate School of Basic Sciences also provides financial and infrastructure support for the Training Core. Lastly, the supporting letter from the UTMB Provost enumerates the current and future commitments to the ITS, which assure the success of this oversight entity for our innovative training program.