Advancing Child Health Through Cellular and Molecular Biology

描述（由申请人提供）：密歇根大学儿童健康研究职业发展奖（CHRCDA）项目名为“通过细胞和分子生物学促进儿童健康”，旨在支持有前途的年轻儿科研究者的研究职业发展。本研究项目的重点是培养年轻儿科研究者的研究项目，他们的工作旨在促进我们对儿童健康中的生物系统和疾病过程的理解。该计划特别强调研究探究的三个基本领域-细胞和分子生物学，遗传学和发育生物学，细胞生长，宿主防御和免疫学，以及最近的生物成像和生物标志物疾病发现和发病机制。该方案的具体目标是：(a)为初级儿科医生-科学家提供基础设施、技术和机会，以研究影响儿童健康的疾病的基本机制和发病机制；(b)为初级儿科医师和科学家提供独特的机会，以获得细胞和分子生物学以及相关生物信息学/系统生物学方法方面新的、创新的和最先进的科学专业知识；(c)为初级儿科医师和科学家提供建立成功的独立研究项目所需的研究理解和实验研究技能；(d)招募有才华的初级儿科医生，特别是针对少数族裔和女性候选人从事学术儿科工作。为了实现这些目标，我们汇集了来自不同生物医学研究领域的资深教师作为我们的学员的研究导师。该项目设立了一个咨询委员会来监督CHRCDA学者的遴选，并设立了两名招聘官员，协助确定和招聘少数族裔和女性候选人。CHRCDA学者参加细胞和分子生物学的强化培训计划，以及旨在确保他们继续研究发展的指导计划。该项目培训了40多名儿科研究人员，他们成功地建立了研究项目，旨在提高我们对儿童疾病的理解，并开发新的治疗方法来治疗儿童疾病。

DESCRIPTION (provided by applicant): The University of Michigan Child Health Research Career Development Award (CHRCDA) program entitled "Advancing Child Health through Cellular and Molecular Biology" is designed to support the research career development of promising young pediatric investigators. The focus of this research program is to foster the research programs of young pediatric investigators whose work is designed to advance our understanding of biological systems and disease processes in child health. The program places particular emphasis on three fundamental areas of research inquiry-cellular and molecular biology, genetics and developmental biology, cellular growth, host defense and immunology, and more recently, bioimaging and biomarker disease discovery and pathogenesis. The specific goals of the program are: (a) to provide junior pediatric physician- scientists with the infrastructure, technologies and opportunity to study basic mechanisms and the pathogenesis of diseases that impact children's health; (b) to provide a unique opportunity for junior pediatric physician-scientists to acquire new, innovative and state-of the art scientific expertise in cellulr and molecular biology and the associated bioinformatics/systems biology approaches; (c) to provide junior pediatric physician-scientists with the research understanding and bench research skills required to establish a successful independent research program; and (d) to recruit talented junior pediatricians with particular efforts directed towards minority and woman candidates to careers in academic pediatrics. To achieve these goals, we have assembled senior faculty from diverse biomedical research fields to serve as research mentors for our trainees. The program has established an advisory committee to oversee the selection of CHRCDA scholars and the program has put in place two recruitment officers to assist in the identification and recruitment of minority and women candidates. The CHRCDA scholars participate in intensive training programs in cellular and molecular biology as well as a mentorship program designed to ensure their continued research development. This program has contributed to the training of more than 40 pediatric-investigators who have gone on to establish successful research programs designed to improve our understanding of childhood disease as well as develop new therapeutic approaches to treat childhood disease.