Macrophage Dysfunction in Obesity, Diabetes and Atherosclerosis
肥胖、糖尿病和动脉粥样硬化中的巨噬细胞功能障碍
基本信息
- 批准号:9209582
- 负责人:
- 金额:$ 242.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-05-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:ASCL1 geneAdipocytesAdipose tissueAffectAnimal ModelArterial Fatty StreakAtherosclerosisAttenuatedBiochemistryBioinformaticsBiometryBreedingCellsChronicClinicalDataDatabasesDiabetes MellitusDietDissectionEnvironmentFatty acid glycerol estersFunctional disorderGoalsHematopoietic stem cellsHumanHyperglycemiaHyperlipidemiaImpairmentInflammationInflammatoryInsulin ResistanceKineticsLeadLinkLipidsMediatingMetabolicMetabolismMicrosurgeryMolecularMorbidity - disease rateMusMyelopoiesisObesityOrganPathologyPathway interactionsPrediabetes syndromeProcessRecruitment ActivityRegulationResearchRoleSignal TransductionSiteTestingThinnessTissuesbasecardiovascular disorder riskcardiovascular risk factordiabeticfeedinghuman subjectinsightmacrophagemonocytemortalitymouse modelnanoparticlenovelnovel therapeutic interventionnovel therapeuticsprogramssmall molecule inhibitortargeted treatmenttranscriptome sequencingtranslational studytreatment strategy
项目摘要
Accumulation of inflammatory macrophages is a common feature in adipose tissue (AT) and other metabolic
organs and in the atherosclerotic plaque. Diabetes further exacerbates macrophage content and inflammation,
which in mouse models impairs atherosclerosis regression; and in obesity, drives insulin resistance. The
overarching hypothesis of this Program is that there are factors and pathways underlying macrophage
accumulation and inflammation in atherosclerotic plaques and AT that are tissue site-independent,
representing common mechanisms, as well as tissue site-dependent, representing discrete regulation by the
local micro-environments. Our Program will test the mechanisms affecting plaque or AT macrophage content
and inflammatory states in diabetes or diet-induced obesity in relation to four key processes: recruitment of
monocytes, macrophage retention/stasis, macrophage inflammation/polarization (M1 vs. M2), and macrophage
regulation of metabolism. To accomplish this, we have developed three Projects as follows: Project 1 will test
these concepts in diabetic atherosclerosis in the context of impaired regression after reduction of
hyperlipidemia; and Projects 2 and 3 will test these concepts in diet-induced obesity mediated by high fat
feeding. In this highly synergistic Program, through coordinated and systematic studies, each Project will
identify the connections, cross talk, and regulatory hierarchies in the diabetic and pre-diabetic insulin resistant
states by which candidate and novel factors drive macrophage content and inflammation. By comparing the
results across the plaque and AT, we will identify those pathways that underlie both common and distinct
mechanisms. All three Projects will test the relevance of findings in mouse macrophages to curated databases
of human monocytes/macrophages and of AT macrophages retrieved from lean and obese human subjects. In
“proof-of-concept” studies, all three Projects will test novel therapeutic agents targeting the key pathways
under study in mouse models in a highly synergistic manner. Taken together, our ultimate goal is to identify
novel therapeutic approaches to suppress exaggerated macrophage accumulation and inflammation that
contribute to increased clinical cardiovascular risk.
炎性巨噬细胞的积累是脂肪组织(AT)和其他代谢性疾病中的常见特征。
器官和动脉粥样硬化斑块中。糖尿病进一步加剧巨噬细胞含量和炎症,
在小鼠模型中,它损害动脉粥样硬化消退;在肥胖症中,它驱动胰岛素抵抗。的
该项目的首要假设是,巨噬细胞的潜在因素和途径
动脉粥样硬化斑块和AT中的积聚和炎症是组织部位无关的,
代表共同的机制,以及组织部位依赖性,代表离散的调节,
当地的微环境。我们的计划将测试影响斑块或AT巨噬细胞含量的机制
糖尿病或饮食诱导的肥胖症的炎症状态与四个关键过程有关:
单核细胞、巨噬细胞滞留/停滞、巨噬细胞炎症/极化(M1与M2)和巨噬细胞
调节新陈代谢。为了实现这一目标,我们开发了以下三个项目:项目1将测试
这些概念在糖尿病动脉粥样硬化的背景下受损的消退后减少,
项目2和3将在高脂血症介导的饮食诱导的肥胖中测试这些概念。
喂食在这个高度协同的计划中,通过协调和系统的研究,每个项目将
确定糖尿病和糖尿病前期胰岛素抵抗中的联系、串扰和调节层次,
候选因子和新因子驱动巨噬细胞含量和炎症的状态。通过比较
通过分析斑块和AT的结果,我们将确定共同和不同的通路
机制等这三个项目都将测试小鼠巨噬细胞中的发现与策划数据库的相关性
人单核细胞/巨噬细胞和从瘦的和肥胖的人受试者中回收的AT巨噬细胞。在
“概念验证”研究,所有三个项目都将测试针对关键途径的新型治疗药物
在小鼠模型中以高度协同的方式进行研究。综上所述,我们的最终目标是确定
抑制过度的巨噬细胞积聚和炎症的新的治疗方法,
导致临床心血管风险增加。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Edward A Fisher其他文献
Technology Insight: targeting of biological molecules for evaluation of high-risk atherosclerotic plaques with magnetic resonance imaging
技术洞察:利用磁共振成像靶向生物分子以评估高危动脉粥样硬化斑块
- DOI:
10.1038/ncpcardio0013 - 发表时间:
2004-11-01 - 期刊:
- 影响因子:44.200
- 作者:
Michael J Lipinski;Valentin Fuster;Edward A Fisher;Zahi A Fayad - 通讯作者:
Zahi A Fayad
Rapid regression of atherosclerosis: insights from the clinical and experimental literature
动脉粥样硬化的快速消退:来自临床和实验文献的见解
- DOI:
10.1038/ncpcardio1086 - 发表时间:
2008-02-01 - 期刊:
- 影响因子:44.200
- 作者:
Kevin Jon Williams;Jonathan E Feig;Edward A Fisher - 通讯作者:
Edward A Fisher
Edward A Fisher的其他文献
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{{ truncateString('Edward A Fisher', 18)}}的其他基金
Novel regulatory mechanisms controlling hepatic apoB-Lp lipid loading and secretion
控制肝脏apoB-Lp脂质负荷和分泌的新调控机制
- 批准号:
10628991 - 财政年份:2023
- 资助金额:
$ 242.72万 - 项目类别:
Administrative, Biostatistics, Data Management, and Bioinformatics Core
行政、生物统计学、数据管理和生物信息学核心
- 批准号:
10616527 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Administrative, Biostatistics, Data Management, and Bioinformatics Core
行政、生物统计学、数据管理和生物信息学核心
- 批准号:
10424901 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin Resistance
解决动脉粥样硬化斑块和胰岛素抵抗其他部位的巨噬细胞炎症
- 批准号:
10424904 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Diseases
动脉粥样硬化和心脏代谢疾病中的巨噬细胞功能障碍
- 批准号:
10616525 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Macrophage Dysfunction in Atherosclerosis and Cardiometabolic Diseases
动脉粥样硬化和心脏代谢疾病中的巨噬细胞功能障碍
- 批准号:
10424900 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Resolving Macrophage Inflammation in Atherosclerotic Plaques and Other Sites in Insulin Resistance
解决动脉粥样硬化斑块和胰岛素抵抗其他部位的巨噬细胞炎症
- 批准号:
10616536 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Macrophage Dysfunction in Obesity, Diabetes and Atherosclerosis
肥胖、糖尿病和动脉粥样硬化中的巨噬细胞功能障碍
- 批准号:
9925242 - 财政年份:2017
- 资助金额:
$ 242.72万 - 项目类别:
Beta-catenin signaling in endothelial cells during cerebral malaria
脑型疟疾期间内皮细胞中的β-连环蛋白信号传导
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9144854 - 财政年份:2015
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