Waisman Intellectual and Developmental Disabilities Research Center

韦斯曼智力和发育障碍研究中心

基本信息

批准号：
9355655
负责人：
Qiang Chang
金额：
$ 110.16万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-22 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9355655
关键词：
Address Agriculture Animals Award Behavioral Bioinformatics Biological Biological Response Modifier Therapy Biological Sciences Biomanufacturing Biometry Brain imaging CGG repeat Cell Culture Techniques Child Clinic Clinical Clinical Research Clinical Trials Clinical assessments Cognitive Therapy Communities Consultations Cryopreservation Cyclic GMP Development Diagnostic Ecology Educational workshop Electroencephalography Engineering Environment FMR1 Faculty Family Fostering Funding Generations Genes Genetic Engineering Genetic Variation Health Health Services Research Home environment Human Human Cell Line Imaging Device Individual Institutes Intellectual functioning disability Intervention Investigation Joints Knowledge Laboratories Language Disorders Length Letters Liquid substance Location Magnetic Resonance Imaging Mental Retardation and Developmental Disabilities Research Centers Mentors Methods Mission Modeling Molecular Mouse Strains National Institute of Child Health and Human Development Neurosciences Nursery Schools Participant Pathogenesis Pathology Pharmacy facility Phenotype Positron-Emission Tomography Prevention Privatization Production Productivity Program Development Public Health Quality of life Rat Strains Recruitment Activity Request for Applications Research Research Personnel Research Project Grants Resources Rodent Scanning Schools Science Scientific Advances and Accomplishments Scientist Seasons Series Services Sum System Teacher Professional Development Techniques Technology Therapeutic Training Training Programs Translational Research United States National Institutes of Health Universities Variant Veterinary Medicine Wisconsin base biobehavior collaborative approach college design experience human subject induced pluripotent stem cell innovation instrumentation interdisciplinary collaboration leadership development medical schools meetings method development microPET mutant nervous system development neuroimaging next generation nonhuman primate novel therapeutics post-doctoral training programs science education special interest group training opportunity translational research program undergraduate student

项目摘要

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, biobehavioral, and bio-behavioral sciences. The Waisman IDDRC brings together 46 PIs from 21 academic departments from the UW-Madison's Schools of Medicine and Public Health, Veterinary Medicine, Pharmacy, Agriculture and Life Sciences, Letters and Science, Education, Engineering, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, and biostatistical and bioinformatics expertise; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical assessment, behavioral methods development, and cGMP biomanufacturing of therapeutics; Brain Imaging (Core C), providing access to state-of-the-art neuroimaging instrumentation (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in the generation and characterization of mutant or genetically engineered strains of mice and rats, the generation of induced pluripotent stem cell lines from humans with IDD conditions, and facilities for phenotypic characterization of these models using molecular, cellular and behavioral technologies. In addition, we request support for a Research Project that is focused on the impact of variations in CGG repeat length in the FMR1 gene on health and function at the cellular through organismal level, using both cell culture models and human subjects. We propose to provide core support to 79 research projects headed by 46 PIs addressing three broad themes relevant to IDD: 1) nervous system development and pathogenesis, 2) IDD conditions, and 3) assessment, interventions, and therapeutics. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations sharpening our focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.

我们寻求持续支持Waisman中心的智力和发展障碍研究中心是一项全面的跨学科计划，重点是跨越生物学，生物行为和生物行为科学。 Waisman IDDRC汇集了来自21个学术部门的46个PI 威斯康星大学麦迪逊分校的医学和公共卫生，兽医医学，药房，农业和生活科学，文书和科学，教育，工程和人类生态学。此申请请求支持行政核心（核心A），提供科学领导，计划和教师发展，促进跨学科合作，生物统计学和生物信息学专业知识；和三个创新科学核心服务：临床翻译（核心B），提供服务，资源和培训招募人类参与者，临床评估，行为方法发展和CGMP 治疗学生物制造；脑成像（核心C），提供获得最新神经影像的访问仪器（3T MRI，PET和MICROPET扫描仪，非人类灵长类动物和啮齿动物扫描，以及脑电图记录系统），以及图像获取和分析的专业知识和工具；和IDD 模型（核心D），在一代和表征中提供资源，专业知识和技术服务小鼠和大鼠的突变体或遗传工程菌株，产生诱导的多能干细胞来自IDD条件的人类的线条，以及使用这些模型表征表征的设施分子，细胞和行为技术。此外，我们要求支持一个研究项目侧重于FMR1基因中CGG重复长度变化对健康和功能的影响使用细胞培养模型和人类受试者的细胞通过生物水平。我们建议为由46个PI领导的79个研究项目提供核心支持，以解决三个广泛的主题与IDD相关：1）神经系统发育和发病机理，2）IDD条件，3）评估，干预措施和治疗学。总的来说是Waisman中心的核心服务和研究项目 IDDRC将刺激新的跨学科IDD研究，并增强现有的IDD调查锐化我们专注于针对IDD条件的发现，预防和治疗以及改善生活质量 IDD及其家人的个人。