Waisman Center Intellectual and Developmental Disabilities Research Center

魏斯曼中心智力与发育障碍研究中心

• 批准号: 10678922
• 负责人: Qiang Chang
• 金额: $ 123.73万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10678922
• 关键词: Address; Agriculture; Animals; Attention deficit hyperactivity disorder; Award; Behavior Therapy; Behavioral; Bioinformatics; Biological; Biological Response Modifier Therapy; Biological Sciences; Biometry; Brain imaging; Child; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cognitive; Communities; Consultations; Development; Diagnostic Services; Ecology; Education; Educational workshop; Electroencephalography; Engineering; Environment; Exposure to; Faculty; Family; Fellowship; Fostering; Funding; Generations; Genetic Engineering; Genomics; Home; Human; Human Cell Line; Imaging Device; Individual; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Investigation; Joints; K-Series Research Career Programs; Knowledge; Laboratories; Language Disorders; Letters; Liquid substance; Machine Learning; Magnetic Resonance Imaging; Mentors; Methods; Mission; Modeling; Molecular; Mouse Strains; National Institute of Child Health and Human Development; Neurosciences; Nursery Schools; Participant; Pathology; Positron-Emission Tomography; Prevention; Privatization; Production; Productivity; Program Development; Public Health; Quality of life; Rattus; Request for Applications; Research; Research Personnel; Research Project Grants; Resources; Rodent; Scanning; Schools; Science; Scientific Advances and Accomplishments; Scientist; Seasons; Series; Services; Social Work; Sum; Symptoms; System; Teacher Professional Development; Techniques; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; Wisconsin; autistic children; behavioral phenotyping; biobehavior; clinical translation; collaborative approach; college; community clinic; cost effective; design; experience; functional near infrared spectroscopy; human pluripotent stem cell; improved; innovation; instrumentation; interdisciplinary approach; interdisciplinary collaboration; leadership development; medical schools; meetings; method development; microPET; mutant; nervous system disorder; neurobehavioral; neurodevelopment; neuroimaging; next generation; nonhuman primate; post-doctoral training; pre-doctoral; programs; recruit; special interest group; stem cells; training opportunity; translational research program; treatment services; undergraduate student

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, behavioral, and biomedical sciences. The Waisman IDDRC brings together 60 PIs from 24 academic departments from the UW-Madison’s Schools of Medicine and Public Health, Veterinary Medicine, Agriculture and Life Sciences, Letters and Science, Education, Engineering, Social Work, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, oversight of training programs, biostatistical and bioinformatics expertise; and dissemination of knowledges and best practices; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical research coordination/navigation, clinical assessment, behavioral methods development, and production of clinical grade biotherapeutics for use in clinical trials; Brain Imaging (Core C), providing access to state-of- the-art neuroimaging instrumentation for both human and animal studies (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, an fNIRS, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in cellular and molecular neuroscience, the generation and manipulation of human pluripotent stem cell (hPSC) lines from humans with IDD conditions, as well as the generation and behavioral phenotyping of mutant or genetically engineered strains of mice and rats as models of IDD conditions. In addition, we request support for a Research Project that addresses a fundamental question on the emergence of ADHD symptoms in children with ASD, using a multidisciplinary approach that combines the power of neurobehavioral, brain imaging, statistical genomics, and machine learning analyses. We propose to provide core support to 69 research projects headed by 44 PIs addressing three broad themes relevant to IDD: 1) neurodevelopment and mechanisms, 2) disorders of the nervous system, and 3) assessments and interventions. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations, with a sharp focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.

我们寻求韦斯曼中心智力和发育障碍研究中心的持续支持，

项目成果

CMOT: Cross-Modality Optimal Transport for multimodal inference.

CMOT：多模式推理的跨模式最佳传输。

• DOI: 10.1186/s13059-023-02989-8
• 发表时间: 2023-07-11
• 期刊: Genome biology
• 影响因子: 12.3

Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer's Disease.

在富含阿尔茨海默氏病风险的队列中，自我报告的听力损失和纵向认知功能。

• DOI: 10.3233/jad-200701
• 发表时间: 2020
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Fields TN;Mueller KD;Koscik RL;Johnson SC;Okonkwo OC;Litovsky RY
• 通讯作者: Litovsky RY

Spatial Language and Cognition in Autistic Preschoolers.

自闭症学龄前儿童的空间语言和认知。

• DOI: 10.1007/s10803-022-05883-7
• 发表时间: 2024
• 期刊: Journal of autism and developmental disorders
• 影响因子: 3.9
• 作者: Prescott,KathrynE;Crespo,Kimberly;EllisWeismer,Susan
• 通讯作者: EllisWeismer,Susan

Movement variability can be modulated in speech production.

运动的可变性可以在言语产生中进行调节。

• DOI: 10.1152/jn.00095.2022
• 发表时间: 2022
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Tang,Ding-Lan;Parrell,Benjamin;Niziolek,CarolineA
• 通讯作者: Niziolek,CarolineA

Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI.

• DOI: 10.1016/j.neuroimage.2022.119475
• 发表时间: 2022-10-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Guerrero-Gonzalez, Jose M.;Yeske, Benjamin;Kirk, Gregory R.;Bell, Michael J.;Ferrazzano, Peter A.;Alexander, Andrew L.
• 通讯作者: Alexander, Andrew L.