Regional Center of Research Excellence in Cancer and Other Non-Communicable Disease Epidemiology and Prevention in Vietnam

在越南，快速的经济增长、工业化和广泛采用西方生活方式 伴随着新出现的非传染性疾病(NCDs)疫情。NCD在越南的研究， 然而，这方面的研究非常有限，主要局限于非传染性疾病患病率评估和危险因素监测。 目前，还没有针对癌症、糖尿病或其他非传染性疾病的基于人群的流行病学研究计划 在越南，由于缺乏以人群为基础的癌症登记，缺乏训练有素的调查人员，以及 缺乏适当的研究支持基础设施。为了应对这些挑战，我们计划建立一个多层次的 美国-越南-中国机构合作计划和建设地区卓越研究中心 (RCRE)用于越南的非传染性疾病研究。我们的长期目标是建立一个自给自足、高影响力的非传染性疾病 在越南建立研究和培训中心，并为非传染性疾病建立一个以人群为基础的大型队列研究 在那里做研究。在本申请中，我们建议建立由范德比尔特领导的正式合作伙伴关系 流行病学中心(VEC)和范德比尔特-英格拉姆癌症中心，拥有出色的 在非传染性疾病研究和能力建设方面卓有成效，特别是在亚洲和越南国家 癌症控制研究所，全国癌症护理和控制的领先者。我们的地区合作伙伴上海 市疾病控制和预防中心(SCDC)将在建立非传染性疾病研究方面提供专业知识 以及与越南最相关的控制程序。我们在越南的其他合作伙伴河内医疗 越南大学和河内公共卫生学院在非传染性疾病预防研究方面处于领先地位。陆博士 将为RCRE带来他在协调健康方面的多年经验- 在越南的相关活动。我们将召开一次协商会议，评估需求、能力，并制定 优先事项包括来自主要医科大学、癌症登记机构、政府和非政府组织的意见 政府在非传染性疾病研究方面的关键利益相关者。我们将通过以下途径提供研究能力增强培训 多次实地考察，一次国内研讨会，一次全国非传染性疾病研究会议，以及两个奖学金 越南调查人员在SCDC和VEC接受更深入的培训。我们将进行病例控制。 对乳腺癌的研究和对2型糖尿病的社区调查，这是两种特定公共卫生的非传染性疾病 在越南关注，并收集生物标本，为未来的多学科研究奠定基础。 通过这些活动，我们将建立调查研究支助核心，即生物检疫处理 和生物库核心，以及生物信息学和信息学核心，这是非传染性疾病必不可少的基础设施 流行病学研究，并为未来的非传染性疾病研究开发一系列研究工具和方案 越南。我们还将制定计划，为越南建立一个长期的研究和培训计划， 也与其邻国LMIC国家高度相关。这些公司之间的长期合作 合作伙伴以及强有力的机构支持和承诺确保了成功实施这一区域合作伙伴关系。

Rapid economic growth, industrialization, and widespread adoption of a western lifestyle in Vietnam have been accompanied by an emerging epidemic of non-communicable diseases (NCDs). NCD research in Vietnam, however, is very limited and mainly restricted to NCD prevalence assessment and risk factor surveillance. Currently, there is no population-based epidemiological research program for cancer, diabetes, or other NCDs in Vietnam due to the lack of a population-based cancer registry, a dearth of well-trained investigators, and the absence of proper research support infrastructure. To address these challenges, we plan to establish a multi- institutional US-Vietnam-China partnership to plan and build a Regional Center of Research Excellence (RCRE) for NCD research in Vietnam. Our long-term goal is to establish a self-sustaining, high-impact NCD research and training center in Vietnam and to establish a large population-based cohort study for NCD research there. In this application, we propose to establish a formal partnership to be led by the Vanderbilt Epidemiology Center (VEC) and the Vanderbilt-Ingram Cancer Center, institutes with outstanding records of excellence in NCD research and capacity-building in LMICs, particularly in Asia, and the Vietnam National Institute for Cancer Control, the national leader in cancer care and control. Our regional partner, the Shanghai Municipal Center for Disease Control and Prevention (SCDC), will provide expertise in building NCD research and control programs that are most relevant to Vietnam. Our other partners in Vietnam, Hanoi Medical University and Hanoi School of Public Health, are leaders in Vietnam in NCD prevention research. Dr. Luu from the University of South Florida will bring to the RCRE his years of experience in coordinating health- related activities in Vietnam. We will conduct a consultative meeting to assess needs, capacity, and to set priorities that incorporate input from major medical universities, cancer registries, and government and non- governmental key stakeholders for NCD research. We will provide research capacity enhancement training via multiple site visits, an in-country workshop, a national NCD research conference, and scholarships to two Vietnamese investigators for more in-depth training at the SCDC and VEC. We will conduct a case-control study for breast cancer and a community survey for type 2 diabetes, two NCDs of particular public health concern in Vietnam, and collect biospecimens that will lay a foundation for future multi-disciplinary research. Through these activities, we will establish the Survey Research Support Core, the Biospecimen Processing and Biorepository Core, and the Bioinformatics and Informatics Core, the infrastructure essential to NCD epidemiology research, and develop an array of study instruments and protocols for future NCD studies in Vietnam. We will also develop plans to establish a longer-term research and training program for Vietnam that is also highly relevant for its neighboring LMIC countries. The long-standing collaborations among these partners and the strong institutional supports and commitments ensure success in implementing this RCRE.