Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

摘要 分子生物学和遗传学的技术和知识的快速发展和进步 导致了癌症病因学研究的重大突破。虽然癌症流行病学领域正在发展 迅速迈向以跨学科和多学科协作研究为中心的新时代 主题，在流行病学、分子生物学、 和遗传学。范德比尔特癌症分子和遗传流行病学培训计划(范德比尔特 MAGEC)于2012年推出，由NCI R25资助，旨在填补这一空白，目标是提供 来自不同学科的博士后研究员，拥有方法学工具、实践实验室和调查- 研究知识，实践研究和撰写资助金的经验，是启动独立 从事癌症的分子和遗传流行病学研究。范德比尔特MAGEC的具体目标 计划是：1)招聘具有丰富流行病学背景的不同种族的杰出候选人， 遗传学和/或生物学。2)提供个性化的教学培训，以补充每个学员的 之前的培训背景，并引导他们进入他们想要的职业道路(分子或遗传流行病学 癌症)。这种培训包括课程、研讨会、工作室、期刊俱乐部、会议和研究补助金。 准备工作。3)为每名学员建立一个多学科的导师团队，并将学员纳入NCI- 资助癌症流行病学研究项目。4)评估范德比尔特MAGEC计划的影响 通过跟踪短期和长期结果。所有受训人员的预期短期成果包括出版 在同行评议的期刊上发表高质量的论文，并向内部或外部基金提交拨款提案 该机构基于NIH格式。长期结果包括癌症研究、职业安置和美国国立卫生研究院 拨款。MAGEC计划，建立在出色的研究和教育培训环境基础上；a 26名优秀的、资金充足的研究人员和教育工作者；66个正在进行的尖端研究项目； 出色的数据/生物武器和人口资源；以及丰富的跨学科培训历史，满足了 在最初的四个赠款年取得了显著的成功。共有9名研究员已收到或目前正在收到 MAGEC培训；其中两人在主要大学获得终身教职；一人获得K99R00 有5人提交了职业发展申请(K22、K99R00、K01和DP5)或R03赠款。 MAGEC受训人员为30种出版物做出了贡献，其中14种是第一作者。该计划已经成熟，正在进行一次极好的 准备过渡到T32培训计划。续签计划将支持6名博士后研究员， 包括4名现职研究员：一名在0年级，两名在一年级，二年级、三年级和四年级各一名。预期 MAGEC项目的培训期限为3年。对该计划的持续支持对于 保持其成功并扩大其对培养新一代精英分子和基因的影响 癌症流行病学家和精准医学和预防新时代的领导者。

ABSTRACT The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. While the field of cancer epidemiology is moving rapidly toward a new era in which interdisciplinary and multidisciplinary collaborative research is the central theme, there is a severe shortage of scientists working at the interfaces of epidemiology, molecular biology, and genetics. The Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt- MAGEC), launched in 2012 with NCI R25 funding, was designed to fill the gap with a goal of providing postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey- research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer. The specific aims of the Vanderbilt MAGEC program are: 1) To recruit exceptional, ethnically-diverse candidates with strong backgrounds in epidemiology, genetics, and/or biology. 2) To deliver individualized didactic training tailored to complement each trainee's prior training background and launch them into their desired career paths (molecular or genetic epidemiology of cancer). This training consists of courses, seminars, studios, journal clubs, conferences and research grant preparation. 3) To establish a multi-disciplinary mentor team for each trainee and integrate trainees into NCI- funded cancer epidemiology research projects. 4) To evaluate the impact of the Vanderbilt MAGEC program by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing high-quality papers in peer-reviewed journals and submitting a grant proposal to an internal or external funding agency based on the NIH format. Long-term outcomes include cancer research career placements and NIH grant funding. The MAGEC program, built upon an outstanding research and education training environment; a pool of 26 excellent, well-funded researchers and educators; 66 ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and a rich history of interdisciplinary training, has met with remarkable success during its first four grant years. A total of 9 fellows received or are currently receiving MAGEC training; of these, two obtained tenure track positions at major universities; one received a K99R00 award; and five submitted a career development application (K22, K99R00, K01 and DP5) or an R03 grant. MAGEC trainees contributed to 30 publications, 14 as first author. The program is mature and is in an excellent position to transition into a T32 training program. The renewal program will support 6 post-doctoral fellows, including 4 current fellows: one at Year 0, two at Year 1, and one each at Year 2, 3 and 4 levels. Expected training duration for the MAGEC program is 3 years. Continued support of the program is essential for sustaining its success and extending its impact on training a new generation of elite molecular and genetic cancer epidemiologists and leaders in the new era of precision medicine and prevention.