Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

摘要 分子生物学和遗传学技术和知识的快速发展和进步 导致了癌症病因学研究的重大突破。当癌症流行病学领域 迅速走向一个新的时代，其中跨学科和多学科的合作研究是中心 在流行病学、分子生物学、 和遗传学。范德比尔特癌症分子和遗传流行病学培训计划（范德比尔特- MAGEC）于2012年在NCI R25资助下启动，旨在填补差距，目标是提供 来自不同学科的博士后研究员与方法工具，实用实验室和调查- 研究知识，动手研究和授予必要的写作经验，推出一个独立的 癌症的分子和遗传流行病学。范德比尔特MAGEC的具体目标 方案是：1）招募特殊的，种族多样的候选人与强大的背景流行病学， 遗传学和/或生物学。2)提供个性化的教学培训，以补充每个学员的 之前的培训背景，并启动他们进入他们想要的职业道路（分子或遗传流行病学 癌症）。该培训包括课程、研讨会、工作室、期刊俱乐部、会议和研究补助金 准备. 3)为每一位学员建立一个多学科的导师团队，并将学员融入NCI- 资助癌症流行病学研究项目。4)评估范德比尔特MAGEC计划的影响 通过跟踪短期和长期结果。所有受训人员的预期短期成果包括出版 在同行评审的期刊上发表高质量的论文，并向内部或外部基金提交赠款申请 根据NIH格式。长期结果包括癌症研究职业安置和NIH 赠款资金。MAGEC计划，建立在一个优秀的研究和教育培训环境; 由26名优秀的、资金充足的研究人员和教育工作者组成的人才库; 66个正在进行的尖端研究项目; 卓越的数据/生物标本和人口资源;以及丰富的跨学科培训历史，已经满足 在最初的四年里取得了巨大的成功。总共有9名研究员已接受或正在接受 MAGEC培训;其中两人在主要大学获得终身职位;一人获得K99 R 00 5人提交了职业发展申请（K22、K99 R 00、K 01和DP 5）或R 03补助金。 MAGEC学员发表了30篇论文，其中14篇为第一作者。该方案是成熟的，是在一个优秀的 过渡到T32培训计划。更新计划将支持6名博士后研究员， 包括4名现任研究员：一名在0年级，两名在1年级，一名在2年级，3年级和4年级。预计 MAGEC计划的培训时间为3年。继续支持该方案至关重要， 保持其成功并扩大其对培养新一代精英分子和遗传学的影响 癌症流行病学家和精准医学和预防新时代的领导者。

ABSTRACT The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. While the field of cancer epidemiology is moving rapidly toward a new era in which interdisciplinary and multidisciplinary collaborative research is the central theme, there is a severe shortage of scientists working at the interfaces of epidemiology, molecular biology, and genetics. The Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt- MAGEC), launched in 2012 with NCI R25 funding, was designed to fill the gap with a goal of providing postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey- research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer. The specific aims of the Vanderbilt MAGEC program are: 1) To recruit exceptional, ethnically-diverse candidates with strong backgrounds in epidemiology, genetics, and/or biology. 2) To deliver individualized didactic training tailored to complement each trainee's prior training background and launch them into their desired career paths (molecular or genetic epidemiology of cancer). This training consists of courses, seminars, studios, journal clubs, conferences and research grant preparation. 3) To establish a multi-disciplinary mentor team for each trainee and integrate trainees into NCI- funded cancer epidemiology research projects. 4) To evaluate the impact of the Vanderbilt MAGEC program by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing high-quality papers in peer-reviewed journals and submitting a grant proposal to an internal or external funding agency based on the NIH format. Long-term outcomes include cancer research career placements and NIH grant funding. The MAGEC program, built upon an outstanding research and education training environment; a pool of 26 excellent, well-funded researchers and educators; 66 ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and a rich history of interdisciplinary training, has met with remarkable success during its first four grant years. A total of 9 fellows received or are currently receiving MAGEC training; of these, two obtained tenure track positions at major universities; one received a K99R00 award; and five submitted a career development application (K22, K99R00, K01 and DP5) or an R03 grant. MAGEC trainees contributed to 30 publications, 14 as first author. The program is mature and is in an excellent position to transition into a T32 training program. The renewal program will support 6 post-doctoral fellows, including 4 current fellows: one at Year 0, two at Year 1, and one each at Year 2, 3 and 4 levels. Expected training duration for the MAGEC program is 3 years. Continued support of the program is essential for sustaining its success and extending its impact on training a new generation of elite molecular and genetic cancer epidemiologists and leaders in the new era of precision medicine and prevention.