Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer

范德比尔特癌症分子和遗传流行病学培训计划

• 批准号: 10628358
• 负责人: XIAO-Ou SHU
• 金额: $ 39.65万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628358
• 关键词: Molecular Epidemiology; Training Programs; cancer epidemiology; genetic epidemiology

PROJECT SUMMARY The rapid development and advancement of technologies and knowledge in molecular biology and genetics have led to major breakthroughs in cancer etiology research. The field of cancer epidemiology is moving rapidly toward a new era in which interdisciplinary and multidisciplinary collaborative research is the central theme. This necessitates a growth of workforce of scientists working at the interfaces of epidemiology, molecular biology, and genetics. The Vanderbilt Training Program in Molecular and Genetic Epidemiology of Cancer (Vanderbilt-MAGEC), launched in 2012 with NCI R25 funding and currently supported by a T32 grant, is designed to fill the gap with a goal of providing postdoctoral fellows from a variety of disciplines with the methodological tools, practical laboratory and survey-research knowledge, and hands-on research and grant writing experience necessary to launch an independent career in the molecular and genetic epidemiology of cancer. The specific aims of the Vanderbilt MAGEC program are: 1) To recruit ethnically-diverse candidates with strong backgrounds in epidemiology, genetics, and/or biology. 2) To deliver individualized didactic training tailored to complement each trainee’s prior training background and launch them into their desired career paths (molecular or genetic epidemiology of cancer). This training consists of courses, seminars, studios, journal clubs, conferences and research grant preparation. 3) To establish a multi-disciplinary mentor team for each trainee and integrate trainees into NCI-funded cancer epidemiology research projects. 4) To evaluate the impact of the Vanderbilt MAGEC program by tracking short- and long-term outcomes. Expected short-term outcomes for all trainees include publishing high-quality papers in peer-reviewed journals and submitting a grant proposal to an internal or external funding agency based on the NIH format. Long-term outcomes include cancer research career placements and NIH grant funding. The MAGEC program, built upon an outstanding research and education training environment; a pool of 31 excellent, well-funded researchers and educators; 100 ongoing, cutting-edge research projects; exceptional data/biospecimen and population resources; and a rich history of interdisciplinary training, has met remarkable success during the current grant cycle. During the last 4 years and 9 months, 12 fellows received or are currently receiving MAGEC training; of these, 2 graduated trainees obtained faculty positions, and both received K12 fellowship awards, and one received two additional career development awards. Another five graduated fellows are working in research-intensive settings. Trainees contributed to 56 publications, 30 as first author. The program is mature and is in an excellent position to continue growing. The renewal program will support 6 postdoctoral fellows. The expected training duration for the MAGEC program is 3 years. Continued support of the program is essential for sustaining its success and extending its impact on training a new generation of elite molecular and genetic cancer epidemiologists and leaders in the new era of precision medicine and prevention.

项目摘要 分子生物学和遗传学技术和知识的快速发展和进步 导致了癌症病因学研究的重大突破。癌症流行病学领域正在 迅速走向一个新的时代，其中跨学科和多学科的合作研究是中心 主题.这就需要增加从事流行病学、 分子生物学和遗传学。范德比尔特培训计划的分子和遗传流行病学的 癌症（范德比尔特-MAGEC），于2012年推出，由NCI R25资助，目前由T32资助， 旨在填补差距，目标是为来自不同学科的博士后研究员提供 方法学工具、实用实验室和调查研究知识以及实践研究和赠款 在分子和遗传流行病学领域开展独立职业所需的写作经验， 癌范德比尔特MAGEC计划的具体目标是：1）招募种族多样的候选人 在流行病学，遗传学和/或生物学方面有很强的背景。2)提供个性化的教学培训 量身定制，以补充每个受训者之前的培训背景，并将他们带入他们想要的职业生涯 癌症的分子或遗传流行病学（Molecular or Genetic Epidemiology of Cancer）这种培训包括课程、研讨会、工作室， 期刊俱乐部、会议和研究补助金准备。3)建立一个跨专业的导师团队， 每个受训者，并将受训者纳入国家癌症研究所资助的癌症流行病学研究项目。4)评价 通过跟踪短期和长期结果，了解范德比尔特MAGEC计划的影响。预期短期 所有学员的成果包括在同行评审的期刊上发表高质量的论文，并提交一份 根据NIH格式向内部或外部资助机构提交赠款提案。长期成果包括 癌症研究职业安置和国家卫生研究院拨款。MAGEC计划，建立在一个杰出的 研究和教育培训环境; 31名优秀、资金充足的研究人员和教育工作者; 100个正在进行的尖端研究项目;特殊的数据/生物标本和人口资源;以及 在跨学科培训方面有着丰富的历史，在本赠款周期内取得了显著的成功。期间 在过去4年零9个月里，12名研究员接受或正在接受MAGEC培训;其中2名 毕业的学员获得了教师职位，两人都获得了K12奖学金，一人获得了两个 额外的职业发展奖励。另有五名研究员在研究密集型 设置.受训人员为56份出版物撰稿，其中30份为第一作者。该方案是成熟的，并在一个 很好的位置继续成长。更新计划将支持6名博士后研究员。预期 MAGEC计划的培训时间为3年。继续支持该方案至关重要， 保持其成功并扩大其对培养新一代精英分子和遗传学的影响 癌症流行病学家和精准医学和预防新时代的领导者。

项目成果

Outcomes of robotic-assisted liver surgery versus laparoscopic liver surgery for treatment of stage I hepatocellular carcinoma.

• DOI: 10.1002/cncr.33979
• 发表时间: 2022-02-15
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Duong, Linh M.;Cai, Hui;Shrubsole, Martha J.;Bailey, Christina E.;Idrees, Kamran;Shu, Xiao-Ou
• 通讯作者: Shu, Xiao-Ou

Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes.

在线虫中，饮食限制可以改善年迈父母的健康状况，但会降低其后代的健康状况。

• DOI: 10.1093/gerona/glz276
• 发表时间: 2020
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: Mautz,BrianS;Lind,MartinI;Maklakov,AlexeiA
• 通讯作者: Maklakov,AlexeiA

Novel Agents for the Management of Endocrine Resistant Breast Cancer.

治疗内分泌耐药乳腺癌的新药。

• DOI: 10.1007/s12609-018-0298-3
• 发表时间: 2018
• 期刊: Current breast cancer reports
• 影响因子: 0.9
• 作者: Reid-Lawrence,Sonya;Mayer,IngridA
• 通讯作者: Mayer,IngridA

Population Stratification in Genetic Association Studies.

• DOI: 10.1002/cphg.48
• 发表时间: 2017-10-18
• 期刊: Current protocols in human genetics
• 作者: Hellwege JN;Keaton JM;Giri A;Gao X;Velez Edwards DR;Edwards TL
• 通讯作者: Edwards TL