Neurodevelopment: attachment, social function and borderline personality

神经发育：依恋、社会功能和边缘人格

• 批准号: 9352373
• 负责人: Joseph Edward Beeney
• 金额: $ 16.06万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-13 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352373
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Age; Amygdaloid structure; Award; Behavior; Behavioral; Biological Neural Networks; Borderline Personality Disorder; Brain; Brain imaging; Caregivers; Clinical; Clinical Psychology; Code; Collaborations; Communities; Complex; Conflict (Psychology); Data; Development; Disease; Doctor of Philosophy; Early Diagnosis; Early treatment; Emotional; Emotional Disturbance; Emotions; Functional Magnetic Resonance Imaging; Functional disorder; Goals; High Prevalence; Human; Hypersensitivity; Individual; Institution; Interview; Lead; Learning; Life; Link; Longevity; Measurement; Measures; Mediating; Mediator of activation protein; Medical; Mental Health; Mental disorders; Mentors; Modeling; Mood Disorders; Nature; Neurosciences; Occupational; Participant; Patient Self-Report; Personality; Phenotype; Play; Psychiatry; Psychopathology; Public Health; Research; Research Personnel; Research Support; Rest; Risk; Risk Factors; Role; Sampling; Security; Seeds; Self-Injurious Behavior; Self-control as a personality trait; Social Development; Social Functioning; Social Problems; Suicide; Suicide attempt; Support System; Symptoms; System; Time; Training; Trust; Universities; adolescent brain development; affective neuroscience; base; behavior measurement; brain behavior; cost; early adolescence; experience; indexing; innovation; mid-career faculty; neurodevelopment; neuroimaging; peer; programs; prospective; relating to nervous system; skills; social; social attachment; social neuroscience; social skills; therapy development

Social problems and disrupted relationships with close, attachment figures are difficulties that are risk factors and/or symptoms of many mental health disorders. Theorists and researchers are increasingly coming to common conclusions: humans are social creatures and when social relationships are disturbed, problems with emotion and self-control arise. Examining disturbance in social functioning and attachment relationships in adolescence, using the brain and behavior as markers of the nature of the disturbance, could facilitate better understanding of how social factors prompt mental health difficulties. Adolescence is particularly important developmental period because brain systems supporting social and emotional processing are rapidly developing at this time. There is, specifically, an urgent need to better understand these difficulties among adolescents with borderline personality disorder (BPD), a severe mental health disorder, characterized by a mix of problems in social and emotional domains. BPD is major public health issue, given its association with extreme misery and debilitation. And yet, the disorder is understudied, particularly within adolescents. The major aims of this project are to (1) examine the relationship between caregiver-attachment relationships and brain and behavioral signs of social functioning and affiliation with peers, (2) determine whether neural and behavioral signs of social dysfunction predict BPD symptoms, and (3) discern whether social functioning and affiliation with peers mediates the relationship between attachment and BPD. Attachment will be measured with an innovative approach to coding caregiver-adolescent conflict interactions. Social functioning will be assessed at 9-months using an fMRI-based Trust Task, which provides indices of trust and collaboration. Connectivity in brain networks, particularly the attachment/affiliation network, during instances of high trust and collaboration within this task will be examined in association with attachment disturbance and BPD symptoms at baseline and over 18-months. Dr. Beeney, the award candidate, is a clinical psychology PhD, seeking to transition to an independent research program focused on social and developmental neuroscience of interpersonal and emotional disturbance and BPD. The above project represents a first step towards this goal. Within the training period, he seeks to train in (1) developmental psychopathology, particularly in relation to adolescent brain development, (2) to learn to analyze the brain as a system of neural networks rather than discreet regions, and (3) learn a life span approach to attachment and train in adolescent development. Drs. Stephanie Stepp and Erika Forbes, both Associate Professors at University of Pittsburgh, will mentor Dr. Beeney. Dr. Stepp is an expert in adolescent development of BPD and Dr. Forbes is an expert in developmental neuroscience of affective disorders. University of Pittsburgh, Department of Psychiatry is a leading research institution, with extensive research support, world-class developmental and neuroimaging researchers, and state-of-the-art brain imaging facilities.

社会问题和与亲密的、依恋的人的关系中断是困难的风险因素 和/或许多精神健康障碍的症状。理论家和研究人员越来越多地认识到 共同结论：人类是社会性的生物，当社会关系被扰乱时， 情绪和自制力就会产生。研究社交功能障碍和依恋关系 青春期，使用大脑和行为作为干扰性质的标志，可以更好地促进 了解社会因素如何引发心理健康问题。青春期尤其重要 发育期，因为支持社交和情绪处理的大脑系统迅速 在这个时候发展。具体地说，迫切需要更好地了解这些困难 青少年边缘人格障碍(BPD)是一种严重的心理健康障碍，其特征是 社会和情感领域的问题混合在一起。BPD是一个主要的公共卫生问题，因为它与 极度的痛苦和虚弱。然而，对这种疾病的研究还不够深入，尤其是在青少年中。这个 本项目的主要目的是(1)考察照顾者-依恋关系和 大脑和行为的社会功能和与同龄人的联系的迹象，(2)决定神经和 社交功能障碍的行为体征预测BPD症状，以及(3)辨别社交功能和 与同伴的关系在依恋和BPD之间起中介作用。附件将被测量 以一种创新的方法对照顾者与青少年之间的冲突互动进行编码。社会职能将是 使用基于功能磁共振成像的信任任务进行9个月的评估，该任务提供信任和协作指数。 大脑网络中的连接性，特别是在高度信任和 在这项任务中的合作将与依恋障碍和BPD症状联系起来进行检查 在基线和18个月以上。贝尼博士，获奖候选人，是临床心理学博士，寻求 过渡到一个独立的研究计划，专注于儿童的社会和发展神经科学 人际关系和情绪障碍以及BPD。上述项目是迈向这一目标的第一步。 在培训期间，他寻求在(1)发展精神病理学方面进行培训，特别是与 青少年大脑发育，(2)学习将大脑作为一个神经网络系统进行分析，而不是 (3)学习一种终身依恋的方法，并在青少年发展过程中进行培训。戴维斯博士。 斯蒂芬妮·斯特普和埃里卡·福布斯都是匹兹堡大学的副教授。 比尼。Stepp博士是BPD青少年发展方面的专家，福布斯博士是 情感障碍的发展神经科学。匹兹堡大学精神病学系是 领先的研究机构，拥有广泛的研究支持，世界级的发育和神经成像 研究人员和最先进的大脑成像设备。