Physiological Correlates of Interpersonal Hypersensitivity in Borderline Personal

边缘型人格者人际过敏的生理相关性

• 批准号: 7921289
• 负责人: Joseph Edward Beeney
• 金额: $ 3.83万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-13 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921289
• 关键词: Address; Affect; Affective; Aggressive behavior; Anger; Behavior; Behavioral; Benign; Borderline Personality Disorder; Characteristics; Clinical; Cognitive; Conflict (Psychology); Control Groups; DSM-IV; Development; Disease; Distress; Electrodes; Electroencephalography; Electromyography; Emotional; Emotions; Employment; Event; Eye; Face; Functional disorder; Gestures; Goals; Hostility; Hypersensitivity; Impaired cognition; Individual; Lead; Left; Life; Link; Maintenance; Major Depressive Disorder; Measures; Mental Health; Mental disorders; Methods; Motivation; Nature; Neurobiology; Neurosciences; Pain; Participant; Patient Self-Report; Patients; Pattern; Perception; Pharmacotherapy; Physiological; Play; Process; Psychotherapy; Public Health; Reaction; Reaction Time; Relative (related person); Reporting; Research; Research Personnel; Research Training; Sampling; Self-Injurious Behavior; Stimulus; Stress; Suicide; Symptoms; System; Testing; Translational Research; Treatment Efficacy; Work; approach behavior; behavior measurement; comparison group; computerized; cost; experience; goal oriented behavior; improved functioning; innovation; neuromechanism; programs; psychologic; public health relevance; relating to nervous system; research study; response; social; suicidal; suicidal behavior; theories; translational approach

DESCRIPTION (provided by applicant): The long-term goal of this research is to identify the specific mechanisms involved in severely disturbed interpersonal relationships that exemplify Borderline Personality Disorder (BPD). Part of this long-term goal is the aim to identify mechanisms using a translational research approach that utilizes several different levels of analysis: neural, physiological, behavioral and phenomenological. The proposed research is specifically aimed at identifying the characteristic patterns of electrophysiological, behavioral and phenomenological reactions to interpersonal rejection in individuals with BPD in contrast to two control groups: individuals with major depression and healthy controls. DSM-IV Axis I and II disorders will be assessed amongst all participants prior to participation in two studies of social rejection. In the first, a startle probe paradigm will be used to assess the threatening nature of rejection related paintings in contrast to paintings depicting acceptance or positive, negative and neutral themes. Startle response will be assessed by electromyography recorded from electrodes just below the left eye. When viewing stimuli that are particularly aversive or threatening to an individual, startle response tends to be elevated, thought to reflect the activation of a defensive motivational system. In the second study, focused on reactions to interpersonal stress, participants will play a computerized ball-toss game which has been validated as an effective manipulation to induce the experience of social rejection. EEG asymmetry will be assessed before, during and after the game. Participants will complete self-report measures of anger, perception of other players, and complete a task measuring behavioral aggression. It is predicted that both BPD and MDD participants will demonstrate elevated startle response to rejection themed paintings, but will show several differences in reactions to social rejection: 1) BPD patients will show greater relative left frontal activation, and 2) will demonstrate greater behavioral aggression and more malevolent perceptions of other "players". The proposed research is important to public health because the disorder is highly prevalent and poses a severe mental health burden. In addition disturbed interpersonal relatedness is a prominent and specific feature of BPD, is highly debilitating, and yet poorly understood. For individuals with BPD, subtle, benign interpersonal events can evoke intense emotional responses, angry outbursts and maladaptive, life threatening behaviors. Uncovering the neural, physiological and behavioral processes that underlie disturbed relatedness in BPD is essential for informing the development of psychotherapy and pharmacotherapy and reducing mental health burden. PUBLIC HEALTH RELEVANCE: Borderline Personality Disorder is a severe mental health disorder characterized by intense negative emotion, anger, aggression, disturbed interpersonal relationships, maladaptive responses to real or perceived abandonment and self-harm and suicidal behaviors. Because real or perceived events in interpersonal relationships are linked to many prominent features of BPD, including aggressive acts, self-harm and suicidality, it is important to understand the nature of this disturbance. Identification of the nature of disturbance in interpersonal relationships can help lead to therapies that can lessen the severe pain and distress of the disorder, and lead to significantly improved functioning in the realms of work and relationships, lessening the costs of the disorder to the individual with BPD and the public.

描述（由申请人提供）：本研究的长期目标是确定严重扰乱人际关系（边缘性人格障碍（BPD））所涉及的具体机制。这一长期目标的一部分是利用转化研究方法来确定机制，该方法利用几个不同层次的分析：神经、生理、行为和现象学。这项研究的具体目的是确定边缘性人格障碍患者对人际排斥的电生理、行为和现象学反应的特征模式，并与两个对照组（重度抑郁症患者和健康对照组）进行对比。在参与两项社会排斥研究之前，将对所有参与者进行 DSM-IV 轴 I 和 II 障碍评估。首先，将使用惊吓探针范式来评估与拒绝相关的绘画的威胁性质，与描绘接受或积极、消极和中性主题的绘画形成鲜明对比。将通过左眼下方电极记录的肌电图来评估惊吓反应。当看到对个人特别厌恶或威胁的刺激时，惊吓反应往往会升高，这被认为反映了防御性动机系统的激活。在第二项研究中，重点关注对人际压力的反应，参与者将玩一个计算机化的抛球游戏，该游戏已被验证为诱导社交拒绝体验的有效操纵。脑电图不对称性将在比赛前、比赛中和比赛后进行评估。参与者将完成愤怒、对其他玩家的看法的自我报告测量，并完成测量行为攻击性的任务。据预测，BPD 和 MDD 参与者都会对拒绝主题的绘画表现出较高的惊吓反应，但对社会拒绝的反应会表现出一些差异：1）BPD 患者将表现出更大的相对左额叶激活，2）将表现出更大的行为攻击性和对其他“玩家”的更恶毒的看法。拟议的研究对公共卫生很重要，因为这种疾病非常普遍，并造成严重的心理健康负担。此外，人际关系紊乱是边缘性人格障碍的一个突出而具体的特征，它会严重削弱人的能力，但人们对此却知之甚少。对于边缘性人格障碍患者来说，微妙、良性的人际事件可能会引起强烈的情绪反应、愤怒的爆发和适应不良、危及生命的行为。揭示 BPD 相关性紊乱背后的神经、生理和行为过程对于为心理治疗和药物治疗的发展以及减轻心理健康负担提供信息至关重要。 公共健康相关性：边缘性人格障碍是一种严重的精神健康障碍，其特征是强烈的负面情绪、愤怒、攻击性、人际关系紊乱、对真实或感知的遗弃的适应不良反应以及自残和自杀行为。由于人际关系中真实或感知的事件与边缘性人格障碍的许多显着特征有关，包括攻击性行为、自残和自杀，因此了解这种障碍的本质非常重要。识别人际关系障碍的性质有助于找到治疗方法，减轻这种疾病带来的严重疼痛和困扰，并显着改善工作和人际关系领域的功能，从而减少边缘性人格障碍患者和公众因该疾病而付出的代价。