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Physiological Correlates of Interpersonal Hypersensitivity in Borderline Personal

边缘型人格者人际过敏的生理相关性

基本信息

批准号：
8061672
负责人：
Joseph Edward Beeney
金额：
$ 3.76万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-13 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8061672
关键词：
Address Affect Affective Aggressive behavior Anger Behavior Behavioral Benign Borderline Personality Disorder Characteristics Clinical Cognitive Conflict (Psychology)Control Groups DSM-IV Development Disease Distress Electrodes Electroencephalography Electromyography Emotional Emotions Employment Event Eye Face Functional disorder Gestures Goals Hostility Hypersensitivity Impaired cognition Individual Lead Left Life Link Maintenance Major Depressive Disorder Measures Mental Health Mental disorders Methods Motivation Nature Neurobiology Neurosciences Pain Participant Patient Self-Report Patients Pattern Perception Pharmacotherapy Physiological Play Process Psychotherapy Public Health Reaction Reaction Time Relative (related person)Reporting Research Research Personnel Research Training Sampling Self-Injurious Behavior Stimulus Stress Suicide Symptoms System Testing Translational Research Treatment Efficacy Work approach behavior behavior measurement comparison group computerized cost experience goal oriented behavior improved functioning innovation neuromechanism programs psychologic public health relevance relating to nervous system research study response social suicidal suicidal behavior theories translational approach

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of this research is to identify the specific mechanisms involved in severely disturbed interpersonal relationships that exemplify Borderline Personality Disorder (BPD). Part of this long-term goal is the aim to identify mechanisms using a translational research approach that utilizes several different levels of analysis: neural, physiological, behavioral and phenomenological. The proposed research is specifically aimed at identifying the characteristic patterns of electrophysiological, behavioral and phenomenological reactions to interpersonal rejection in individuals with BPD in contrast to two control groups: individuals with major depression and healthy controls. DSM-IV Axis I and II disorders will be assessed amongst all participants prior to participation in two studies of social rejection. In the first, a startle probe paradigm will be used to assess the threatening nature of rejection related paintings in contrast to paintings depicting acceptance or positive, negative and neutral themes. Startle response will be assessed by electromyography recorded from electrodes just below the left eye. When viewing stimuli that are particularly aversive or threatening to an individual, startle response tends to be elevated, thought to reflect the activation of a defensive motivational system. In the second study, focused on reactions to interpersonal stress, participants will play a computerized ball-toss game which has been validated as an effective manipulation to induce the experience of social rejection. EEG asymmetry will be assessed before, during and after the game. Participants will complete self-report measures of anger, perception of other players, and complete a task measuring behavioral aggression. It is predicted that both BPD and MDD participants will demonstrate elevated startle response to rejection themed paintings, but will show several differences in reactions to social rejection: 1) BPD patients will show greater relative left frontal activation, and 2) will demonstrate greater behavioral aggression and more malevolent perceptions of other "players". The proposed research is important to public health because the disorder is highly prevalent and poses a severe mental health burden. In addition disturbed interpersonal relatedness is a prominent and specific feature of BPD, is highly debilitating, and yet poorly understood. For individuals with BPD, subtle, benign interpersonal events can evoke intense emotional responses, angry outbursts and maladaptive, life threatening behaviors. Uncovering the neural, physiological and behavioral processes that underlie disturbed relatedness in BPD is essential for informing the development of psychotherapy and pharmacotherapy and reducing mental health burden. PUBLIC HEALTH RELEVANCE: Borderline Personality Disorder is a severe mental health disorder characterized by intense negative emotion, anger, aggression, disturbed interpersonal relationships, maladaptive responses to real or perceived abandonment and self-harm and suicidal behaviors. Because real or perceived events in interpersonal relationships are linked to many prominent features of BPD, including aggressive acts, self-harm and suicidality, it is important to understand the nature of this disturbance. Identification of the nature of disturbance in interpersonal relationships can help lead to therapies that can lessen the severe pain and distress of the disorder, and lead to significantly improved functioning in the realms of work and relationships, lessening the costs of the disorder to the individual with BPD and the public.

描述（由申请人提供）：本研究的长期目标是确定导致边缘型人格障碍（BPD）的严重人际关系障碍的具体机制。这一长期目标的一部分是使用转化研究方法来确定机制，该方法利用几个不同层次的分析：神经，生理，行为和现象学。拟议的研究是专门针对识别的特征模式的电生理，行为和现象学反应的人际关系拒绝BPD的个人相比，两个对照组：个人与重性抑郁症和健康对照。在参与两项社会排斥研究之前，将对所有参与者进行DSM-IV轴I和轴II障碍评估。在第一，惊吓探测范式将被用来评估的威胁性质的拒绝相关的绘画相比，绘画描绘接受或积极的，消极的和中性的主题。将通过从左眼正下方的电极记录的肌电图来评估惊吓反应。当看到对个体特别厌恶或威胁的刺激时，惊吓反应往往会升高，被认为反映了防御性动机系统的激活。在第二项研究中，重点是对人际压力的反应，参与者将玩一个电脑扔球游戏，该游戏已被验证为一种有效的操纵，以诱导社会拒绝的经验。EEG不对称将在比赛前、比赛中和比赛后进行评估。参与者将完成愤怒的自我报告措施，对其他玩家的看法，并完成测量行为攻击的任务。据预测，BPD和MDD参与者都将表现出对拒绝主题绘画的惊吓反应升高，但对社会拒绝的反应将表现出几个差异：1）BPD患者将表现出更大的相对左额叶激活，以及2）将表现出更大的行为攻击性和对其他“玩家”的更恶毒的感知。这项拟议中的研究对公共卫生很重要，因为这种疾病非常普遍，并造成严重的心理健康负担。此外，人际关系紊乱是BPD的一个突出和具体的特征，是高度衰弱的，但知之甚少。对于患有BPD的人来说，微妙的，良性的人际关系事件可以引起强烈的情绪反应，愤怒的爆发和适应不良，危及生命的行为。揭示BPD中相关性障碍的神经，生理和行为过程对于心理治疗和药物治疗的发展以及减少心理健康负担至关重要。公共卫生相关性：边缘型人格障碍是一种严重的心理健康障碍，其特征是强烈的负面情绪、愤怒、攻击性、人际关系紊乱、对真实的或感知到的遗弃的适应不良反应以及自我伤害和自杀行为。由于人际关系中的真实的或感知的事件与BPD的许多突出特征有关，包括攻击性行为，自我伤害和自杀倾向，因此了解这种干扰的性质很重要。识别人际关系障碍的性质可以帮助治疗，可以减轻严重的疼痛和痛苦的障碍，并导致显着改善功能的工作和关系领域，减少成本的障碍与BPD的个人和公众。