Multidisciplinary Training Program in Hypertension

描述(申请人提供)：鉴于美国高血压发病率的上升，以及高血压与心血管发病率和死亡率之间的密切关系，显然需要未来的高血压研究人员。这是佛罗里达大学“高血压多学科训练计划”的第一个竞争性续展申请。T32由UF高血压中心管理，研究项目围绕以下反映指导教师专业知识的主要重叠主题进行组织：内皮损伤和修复；血管张力和血压的神经控制；中枢和外周血管紧张素II以及血压的一氧化氮控制；肺高血压；心血管损伤和肾脏疾病；运动与心血管损伤和健康；高血压和衰老/性二型；高血压和肥胖；妊娠期高血压；高血压的发育起源；降压治疗的药物基因组学方法。UF工程学院、健康与人类绩效学院、医学与药学学院的11个系/分部有27名资金雄厚的潜在导师，其中许多导师正在积极合作。克里斯·贝利斯博士是UF高血压中心主任和T32项目主任。Peter Sayeski博士将成为副主任。该项目的一般监督由内部咨询委员会和外部咨询委员会负责，该委员会由乔治城大学博士凯瑟琳·桑德伯格担任主席。招聘和监测受训人员的进度由PD和招聘和审查委员会(R@R)负责。高血压中心通过以下活动为T32学员提供重点和支持：每月高血压中心系列研讨会；桑德伯格博士的年度探视费用；每位学员培训期间每位外部导师的一次探视费用。培训计划强调，所有受训人员需要有效沟通，方法是参加期刊俱乐部；每年两次在所有积极的导师、PD和R@R委员会面前以及在T32年度务虚会上在内部和外部咨询委员会面前进行口头陈述；在初级从业部的研讨会系列中进行年度陈述；参加每周的实验室会议，并出席国内和国际会议并进行陈述。该T32目前资助3名博士后学生和3名博士后实习生。在这个项目的前5年里，我们毕业了4名博士后实习生(3名现在是博士后，1名回到了医学院)，其中3名参加了培训。我们已经培养了4名博士后研究员(1名医学博士和2名博士后)，他们现在是助理教授，还有一名博士正在寻求学术界或工业界的研究职位。我们要求继续发放这一数额的津贴(3名博士前和3名博士后)。我们正在申请2级、3级和4级的博士后津贴，以适应一些医学博士实习生的招聘。

DESCRIPTION (provided by applicant): Given the rising incidence of hypertension in the US, and the strong relationship between elevated blood pressure and cardiovascular morbidity and mortality, there is a clear need for future hypertension researchers. This is the first competing continuation application of the University of Florida's "Multidisciplinary Training Program in Hypertension". The T32 is administered by the UF Hypertension Center and the research program is organized around the following major overlapping themes that reflect the expertise of the mentoring faculty: Endothelial injury and repair; neural control of vascular tone and BP; central and peripheral angiotensin II and nitric oxide control of blood pressure; pulmonary hypertension; cardiovascular damage and renal disease; exercise and cardiovascular injury and health; hypertension and aging/ sexual dimorphism; hypertension and obesity; hypertension in pregnancy; developmental origins of hypertension; pharmacogenomic approaches to antihypertensive treatments. There are 27 well funded, potential mentors drawn from 11 Departments/ Divisions in the UF Colleges of Engineering, Health and Human Performance, Medicine and Pharmacy and many of these mentors are actively collaborating. Chris Baylis Ph.D. is the director of the UF Hypertension Center and T32 Program Director. Peter Sayeski Ph.D., will become Associate director. General oversight of the program is by the Internal Advisory committee and External Advisory committee, chaired by Kathryn Sandberg, Ph.D. (Georgetown University). Recruitment and monitoring of trainee progress is by the PD and the Recruitment and Review (R@R) committee. The Hypertension Center provides the focus and support to the T32 trainees with the following activities: Monthly Hypertension Center seminar series; costs for annual visits of Dr. Sandberg; costs for 1 visit of each external mentor during training period of each trainee. The training program emphasizes the need for all trainees to effectively communicate, accomplished by participation in Journal Club; oral presentations twice a year before all active mentors, PD and the R@R committee and also before both internal and external advisory committees at the annual T32 retreats; annual presentations in the seminar series of the Department of primary affiliation; participation in weekly lab meetings and by attendance and presentation at national and international meetings. This T32 currently funds 3 predoctoral students and 3 postdoctoral trainees. During the first 5 years of this program we graduated 4 Ph.D. trainees (3 now in postdoctoral positions and 1 returned to medical school) with 3 in training. We have trained 4 postdoctoral fellows (an M.D. and 2 Ph.D.s who are now Assistant Professors and a Ph.D. who is currently seeking a research position in academia or industry. We are requesting that this number of stipends (3 predoctoral and 3 postdoctoral) be continued. We are requesting postdoctoral stipends at levels 2, 3 and 4 to accommodate recruitment of some M.D. trainees.