Protein Quality Early in Life: Mechanisms of Growth and Later Obesity Development
Protein Quality Early in Life: Mechanisms of Growth and Later Obesity Development
批准号:
9352844
负责人:
Minghua Tang
金额:
$13.4万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-14 至 2020-05-31
关键词:
ATP phosphohydrolaseAchievementAffectAge-MonthsAmino AcidsArginineBacteroidetesBiological MarkersBiometryBirthBody CompositionBody fatBranched-Chain Amino AcidsChild NutritionClinical SkillsColoradoComplementary FeedingDataData AnalysesDevelopmentDietDietary ProteinsDomestic FowlsEarly InterventionEnvironmentEpidemiologyExposure toFacultyFatty acid glycerol estersFermentationFishesFoodFutureGenesGlycoside HydrolasesGoalsGrowthHarvestHomeostasisImpairmentIndividualInfantInstitutionInsulin ResistanceInsulin-Like Growth Factor IInvestigationIronKnowledgeLeadershipLifeLiteratureLong-Term EffectsMarketingMeatMediator of activation proteinMedicalMentorsMetagenomicsMicrobeMicronutrientsMissionMonitorObesityOutcomeOverweightParticipantPatternPlayPositioning AttributePostdoctoral FellowPreventionProteinsProtocols documentationPublic HealthRandomized Controlled TrialsRecommendationRegulationResearchResearch MethodologyResearch TrainingRibosomal RNARiskRisk FactorsRoleSamplingSerumSolidSourceStatistical MethodsTaxonomyTechniquesTimeToddlerTrainingTraining ProgramsUnited States National Institutes of HealthUniversitiesWeightWeight GainZincacylcarnitinebasecareercareer developmentcohortdoubly-labeled watereffective interventionevidence baseexperiencefeedinggut microbiomeheart disease riskhuman diseaseinsulin sensitivitymeetingsmetabolomicsmetagenomic sequencingmicrobiomemodifiable riskmultidisciplinarynutritionobesity in childrenobesity preventionobesogenicpreventprogramsprotein intakerandomized trialresearch and developmentskillssoundtotal energy expendituretrimethyloxamine
中文摘要
摘要
英文摘要
ABSTRACT
Rapid weight gain during the first two years of life predisposes to later-in-life obesity. However, there is a
fundamental gap in knowledge of what dietary recommendations should be provided to infants and toddlers
to promote optimal growth and prevent rapid weight gain. Dietary protein intake is considered a risk factor
because it accelerates weight and fat gain in infants and toddlers, based primarily on research of dairy protein.
However, the underlying mechanisms are not clear. These findings have been the basis of recent
recommendations to reduce protein intake from birth to 24 months. What is not known is whether all protein
sources have the same weight-accelerating effect. Our research group conducted a randomized controlled
trial in infants consuming a meat- or dairy-based complementary diet from 6 to 12 months of age. Growth
data showed that a dairy-based complementary diet, not meat, leads to impaired linear growth and increased
risk for being overweight. The objective of this proposed project is to investigate the underlying mechanisms and
determine which mediators are predictive for the different growth patterns in this cohort via fecal
microbiome/metagenomics, serum metabolomics and doubly labeled water technique. Although the
candidate has expertise in pediatric nutrition and conducting randomized controlled trials, training in
mechanistic investigations of obesity development and research methodologies are critical to achieve the
long-term goal of becoming a leader in pediatric nutrition focusing on implementing effective interventions
early in life for optimal growth and obesity prevention.
This career development application proposes a 4-year multidisciplinary training program to the candidate,
who is a 4th year postdoctoral fellow transitioning to a junior faculty position. A well-developed training plan
by the candidate and the mentoring team is in place, including 1) Hands-on experience of
microbiome/metagenomics, metabolomics analysis and data interpretation; 2) Hands-on experience of
conducting the doubly labeled water protocol for body composition and total energy expenditure in infants
and toddlers, plus sample analysis and data interpretation; 3) Regular meetings with mentors to monitor
project progress, achievements towards the short- and long-term goals, and didactic trainings; 4) Advanced
coursework in microbiome, metabolomics and biostatistics; 5) Training in leadership and program
management. University of Colorado Anschutz Medical Campus is world-leading research institution and
provides the candidate an excellent research and training environment which facilitates a successful
transition to an independent career in pediatric nutrition and early-in-life obesity prevention.
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会议论文
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批准号:10338092
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依托单位:
海外基金